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The J-curve: blood pressure and cardiovascular disease.

An analysis of data from 22 672 patients with stable coronary artery disease who were treated for the condition showed that reducing blood pressure to too low a level had poor outcomes. In patients with hypertension and coronary artery disease from routine clinical practice, systolic blood pressure of <120 mmHg and diastolic blood pressure of <70 mmHg were both associated with adverse cardiovascular outcomes, including mortality. This supports the idea of a J-curve in optimal blood pressure, since very low diastolic blood pressure leads to poor myocardial perfusion, causing problems.

Vidal-Petiot E, Ford I, Greenlaw N, et al. Cardiovascular event rates and mortality according to achieved systolic and diastolic blood pressure in patients with stable coronary artery disease: An international cohort study. Lancet 2016;388(10056):2142-2152. 6736(16)31326-5

Bridget Farham


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Title Annotation:30 days in medicine
Author:Farham, Bridget
Publication:SAMJ South African Medical Journal
Article Type:Brief article
Date:Dec 1, 2016
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