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The Drug Market for Superficial Bladder Cancer is Predicted to Increase by 10% until 2012.

DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c27291 ) has announced the addition of Superficial Bladder Cancer - Current Mangement and Future Trends to their offering.

Superficial bladder cancers (SBC) comprise tumours with low aggressiveness but a high recurrence rate as well as lesions with a high risk of progression. All SBC are amenable to intravesical therapy and treatment failure is associated to a considerable discomfort for patients that may eventually require aggressive surgery. The current intravesical chemotherapies and immunotherapies have so far shown limitations in reversing the natural history of the disease. For these reasons a load of research has been devoted in the development of new treatment options. Close to 40 different companies has been identified with R&D related activities in this field. New intravesical chemotherapeutic drugs such us gemcitabine (that has already completed the phase II of studies) and EOquinTM (at the early phase I-II experience) have shown an excellent activity profile. From the point of view of immunotherapeutic agents, Mycobacterium cell wall DNA complex (MCC) has shown a high response rate in phase I-II studies whereas Imiquimod, a promising new compound based on preclinical studies, will soon engage in phase I human trials. Analysing the emerging therapeutic strategies shows that drugs inhibiting DNA replication and related mechanisms is the leading strategy, closely followed by immunostimulators and antiangioenetic drugs. Some minor strategies are apoptotic inducers, oncolytic viruses, tubule/microtubule binders as well as antisense technology. A number of features make intravesical molecular therapy a feasible new treatment option for SBC. As far as the field of new diagnostic and prognostic tools is concerned, methods to improve the endoscopic detection of poorly visible bladder cancers and urine biomarkers for the early detection of a recurrent tumour will enable better clinical outcomes and reduce the need for invasive procedures such us cystoscopy. The 5-aminolevulinic acid (ALA) induced fluorescence may soon become routinely adopted during endoscopic procedures. Among the urine biomarkers, the Fluorescent in-situ Hybridization (FISH) has been found to be helpful particularly in those cases (not so infrequent) where a urine cytology test has shown "atypical cells" and all the diagnostic work-up has failed to demonstrate a bladder cancer. New diagnostic opportunities will drive the need for improved therapeutic options and the market for these drugs are estimated to increase at least 10% until 2012.

Topics Covered

Executive summary

Introduction
Superficial bladder cancer (SBC) epidemiology
Table 1. Relevant epidemiological factors for BC

Risk categories of SBC and their natural history
Table 2. Risk categories of superficial bladder cancer according to
European Giudelines
Risk category

How do we approach SBC?
Step 1: make the correct diagnosis
Urine biomarkers
Table 3. Currently FDA approved biomarkers urine tests with
sensitivity and specificity
values.
Step 2: remove the tumour
5-aminolevulinic acid (ALA) induced fluorescence diagnosis of TCC
Step 3: administer the most appropriate treatment

Treatment End Points

Limitations of traditional molecules for SBC
Limitations in efficacy of intravesical treatment in intermediate
risk SBC
Limitations in efficacy of intravesical treatment in high risk SBC
Side effects burden of currently-used intravesical agents

Alternative treatment options
Interferon (IFN) alpha
Table 4. IFN and bladder cancer related R&D.
Gemcitabine
Table 5. Gemcitabine and bladder cancer related R&D.

Investigational drugs
With a cytotoxic mechanism
Table 6. EOquin and bladder cancer related R&D.
With an immunological mechanism
Table 7. Imiquimod and bladder cancer related R&D.

Molecular therapy
Table 8. Antisense and bladder cancer related R&D
Magnetically targeted carriers (MTC)
Polymer microspheres
Antiangiogenetic therapy
Gene therapy
Table 9. Gene therapy and bladder cancer related R&D

Appendix I: Industry related R&D projects for the treatment of
bladder cancer
Company Profiles
Abbott Laboratories Inc - Agensys Inc - AnorMED Inc.
- Anthra Pharmaceuticals - Ariad Pharmaceuticals Inc
- AstraZeneca AB - Avidex Ltd - Axcan Pharma Inc - Bioaccelerate Inc -
Bioenvision - Bioniche Life Sciences Inc - Bristol-Myers Squibb -
Cell Genesys, Inc - Cephalon Inc - Eisai Co Ltd - Eli Lilly -
GlaxoSmithKline Plc - Got-A-Gene AB - Halozyme Therapeutics, Inc. -
ID Biomedical Corporation - IDM S.A - Intracel Holding Corporation -
Introgen Therapeutics - Madaus AG - Medarex Inc -
Millennium Pharmaceuticals Inc - NeoPharma AB - Novartis
International AG - OncoGenex Technologies Inc - PharmaMar SA -
PhotoCure AS - Pierre Fabre Group
Regulon Inc - Sanofi-Aventis - Spectrum Pharmaceuticals Inc -
Sumitomo Pharmaceuticals Co Ltd - Titan Pharmaceuticals, Inc
- Viscum AG - Viventia Biotech Inc


References

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Publication:Business Wire
Date:Nov 8, 2005
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