The Association of Skinfold Anthropometric Measures, Body Composition and Disease Severity in Obese and Non-obese Fibromyalgia Patients: A Cross-sectional Study.
Obesity is characterized with additional fat-free mass (FFM) as well as fat mass (FM). Measurement of FM is more suitable than body mass index (BMI) in evaluating obesity. (3) Several methods can be used for the assessment of body composition such as bioelectric impedance analysis, ultrasound, dual-energy X-ray absorptiometry or skinfold method. Skinfold method can be used as an accurate and convenient method to measure body composition in clinical setting. (4) In previous studies, bioelectric impedance analysis method was used for the body composition analysis of patients with FS. (1,5,6) Ultrasound and skinfolds are validated to be accurate, portable and non-invasive methods in the assessment of FM in normoactive Turkish university students. (7) To our knowledge, there is no study using skinfold method for measuring body composition in patients with FS.
Several studies showed a prevalence of overweight of about 20-30% and a prevalence of obesity of about 40-50% in patients with FS. (2,8,9) Obesity can be considered an aggravating comorbid condition affecting negatively FS severity, global QoL, fatigue and physical function. (2) On the other hand, the associations between disease severity, body composition and obesity related skinfold anthropometric measurements have not been well-studied in obese FS patients. Therefore, in this study, we aimed to determine the effects of obesity and obesity related anthropometric and body composition determiners on the severity of FS and to compare obese, overweight and normoweight FS patients according to general health and psychological status.
PATIENTS AND METHODS
Between December 2013 and May 2014, a total of 70 females with FS and BMI of <30 kg/[m.sup.2] and 100 females with FS and BMI of [greater than or equal to] 30 kg/[m.sup.2] were screened at Ministry of Health Ankara Training and Research Hospital for this cross-sectional study. FS was diagnosed according to 2010 American College of Rheumatology preliminary diagnostic criteria. (10) Individuals with active inflammatory/infectious disease, active psychiatric disease, and recent history of major trauma and active rheumatic disease were excluded. Forty-one patients refused to participate and 28 individuals who met the exclusion criteria were excluded. The World Health Organization (WHO) classification criteria were used to identify obese (BMI >30.0 kg/[m.sup.2]) and overweight patients (BMI=25-29.9). (4) Finally, patients were grouped as 42 obese FS patients (mean age 48.8 [+ or -] 11.6; range 24 to 65 years), 27 overweight FS patients (mean age 47.3 [+ or -] 3.4; range 24 to 61 years) and 32 normoweight FS patients (mean age 47.1 [+ or -] 7.8 years; range 31 to 60 years). In the study, overweight and normoweight FS patients, when used together, were referred to as non-obese FS patients. The study protocol was approved by the Ministry of Health Ankara Training and Research Hospital Ethics Committee. A written informed consent was obtained from each patient. The study was conducted in accordance with the principles of the Declaration of Helsinki.
Symptom severity score (SS) (0-12) and widespread pain index (WPI) (0-19) of FS patients were evaluated separately according to 2010 American College of Rheumatology preliminary diagnostic criteria. (10) General pain severities (general visual analog scale [VAS]), neck and also low back pain (LBP) VAS were assessed separately using 0-10 VAS (0= no pain, 10= most severe pain).
Control and tender point pain pressure threshold (PPT) (kg/[cm.sup.2]) measurements were performed by the Fischer's tissue compliance meter (Pain Diagnostic & Treatment, Italy) that can also be used as an algometer. (11) During algometric studies, tender point (TP) measurements were performed according to 18 TPs defined by the American College of Rheumatology 1990 FS classification criteria, (12) whereas the control point measurements were carried out bilaterally at the thumb nail and midpoint of the forearm volar surface. The individuals were informed that the examination was aimed at determining the pain threshold and not the pain tolerance. Then, pressure was raised at the rate of 1 kg/sec until pain or discomfort occurred; the minimum force that caused pain was termed the PPT. Points that were painful with less than 4 kg/[cm.sup.2] pressure were accepted as TP. The severity of FS was determined with total myalgic score (TMS) and control point score. The sum of the PPTs of the 22 points (18 TPs and four control points) was calculated as TMS (kg/[cm.sup.2]) and the sum of the PPTs of the control points was termed as control point score (kg/[cm.sup.2]). (13)
Health Assessment Questionnaire (HAQ), which evaluates eight activities of daily living (dressing and grooming, arising, eating, walking, hygiene, reaching, grip and activities such as running errands), was used to assess functional difficulties in 0-3 scale. (14)
Isometric hand grip strength measurements were determined with Jamar hand dynamometer (Preston Co., Jackson, MI, USA). Three trials were performed for each measurement (with a 15-sec interval between each short grip strength measurement) and the means were recorded.
Psychological status was utilized using Beck Depression Inventory in all groups. (15) Waist circumference (WC) was determined using a spring scale at the end of gentle expiration at the level midway between the lower rib margin and the iliac crest (cut-off points for cardiovascular disease risk were 102 cm for males and 88 for females as defined by the criteria of WHO). Hip circumference was determined at the largest posterior extension of the buttocks. Waist hip ratio (WHR) was calculated by dividing these two values (cut-off points for cardiovascular disease risk was 1.0 in males and 0.85 in females as defined by the criteria of WHO). (16) WC and WHR were used to assess body fat distribution and specifically as indicators of intraabdominal or visceral fat mass.
The amount and dispersion of body fat were evaluated by measuring the thickness of subcutaneous adipose tissue. For skinfold anthropometry, triple measurements were taken in four standard sites: biceps and triceps (limb), subscapular and suprailiac skinfolds (trunk) using a caliper (Lafayette Instrument Co. Indiana 47903). The sum of four skinfolds (triceps, biceps, subscapular and suprailiac) was used to calculate body density. Body density was estimated according to the Durnin and Womersley method, (17) and FM calculated with the Siri's equation.
All statistical analyses were performed using SPSS for Windows version 15.0 software package (SPSS Inc., Chicago, IL, USA). A level of p<0.05 was considered statistically significant. One-way analysis of variance was conducted on three patient groups. Bonferroni post-hoc tests were conducted when analysis of variance showed significant effects. The distribution of categorical variables in groups was compared using Pearson Chi-square test. Pearson correlation analysis was conducted to determine the relationships between BMI and disease severity parameters. Results were reported as mean [+ or -] standard deviation and median (minimum-maximum) when appropriate.
There was no difference between the groups in terms of mean age (p>0.05). Disease duration was higher in obese FS patients than non-obese FS patients (p<0.05). Grip strength values were lower in obese FS patients than non-obese FS patients (Table 1).
Symptom severity and WPI scores of obese FS patients were higher than non-obese FS patients. Neck pain VAS was higher in obese FS patients than non-obese FS patients. LBP VAS and general VAS values were higher in obese- and overweight FS patients than normoweight FS patients (Table 1).
Mean control point score and TMS values of obese FS patients were lower than non-obese FS patients. The mean number of TP was higher in obese FS patients than non-obese FS patients. The mean value of number of TP was not different among groups (p>0.05) The mean value of HAQ was higher in obese FS patients than non-obese FS patients but there was no difference among groups regarding Beck Depression Inventory scores (p>0.05) (Table 1).
The mean WC and WHR values were different among groups, according to the cut-off points for relative risk defined by WHO, cardiovascular disease risk determined by WHR (all p<0.001) and WC (all p<0.001) in obese, normoweight and overweight FS patients (Table 2).
Fat mass and body fat percentage were higher in obese FS patients than non-obese FS patients (p<0.001) (Table 2). Correlation analyses revealed positive correlations between BMI and SS (r=0.339, p=0.001), WPI (r=0.688, p<0.001), and number of tender points (NTP) (r= 0.426, p<0.001) values and negative correlation with TMS (r=-0.354, p<0.001).
Stepwise linear regression analyses were conducted to identify the affecting factors for disease severity (TMS, SS, WPI). Regression analysis showed that increased body fat percentage ([R.sup.2]=0.53) and increased VAS (general pain) ([R.sup.2]=0.20) were associated with higher WPI. Body fat percentage was found to be a more prominent factor on WPI. A total of 73% variance was explained with body fat percentage and VAS on WPI.
In this study, we evaluated the effects of obesity and obesity related skinfold anthropometric and body composition determiners on the severity of FS and investigated the effect of FS on general health and psychological status. Clinical course of FS is more serious in obese FS patients than overweight and normoweight FS patients. BMI were found related with disease severity parameters (NTP, SS and WPI) and PPT values.
In several studies, a relationship between BMI and nonspecific LBP, other forms of chronic pain and headaches has been reported. The literature shows that obese people have more musculoskeletal pain and physical dysfunction than people with normoweight. (8) McKendall and Haier (18) found diminished mechanical pain thresholds in healthy obese individuals. Overweight category was also found related with an increased risk for cardiovascular disease in both sexes, LBP and poor QoL in females. (19) We observed that chronic neck pain and LBP were frequent in our obese and non-obese FS patients. Moreover, in overweight FS patients, LBP and general VAS and TMS values were higher than normo-weight FS patients. Our obese and overweight FS patients had increased cardiovascular risk which was determined with WHR. However, we did not find any difference among groups according to HAQ values.
Okifuji et al. (20) found that the heightened pain sensitivity to pain TPs in obese FS patients appeared especially in the lower body areas. In addition to centrally modulated sensitivity, the pain sensitivity of obese FS patients may also be affected by the mechanical loads of having to carry extra weight. So, in our study, disease duration was found higher in obese FS patients than overweight and normoweight FS patients. We thought that disease duration could be augmented via obesity related noxious stimuli from the joints and muscles and may be potentiated by sensitivity to noxious stimuli via obesity-related alteration in the endocrine and opioid system.
The easiest explanation for the high prevalence of obesity in FS could be inadequate physical activity. (21) Yunus et al. (9) found that most FS patients are overweight, likely due to physical inactivity. Reduced hand grip strengths and QoL levels of our obese FS patients also indicated that obese FS patients had insufficient physical activity. So, encouraging these patients to physical activity may be essential for increasing QoL levels. Increased physical activity combined with weight loss can improve many adversities in the lives of these patients. Correspondingly, Shapiro et al. (22) evaluated the effects of behavioral weight loss treatment on FS symptoms. At the end of the study, patients showed significant improvement in measures of depression (Beck Depression Inventory), pain, and anxiety, body satisfaction, and QoL. Similarly, Saber et al. (23) investigated the effect of weight loss in FS by laparoscopic Rouxen-Y gastric bypass. After the surgery, the mean BMI was significantly reduced and there was a significant improvement in pain and NTP.
Furthermore, Yunus et al. (9) evaluated 211 female patients with FS. In their study, HAQ scores were significantly correlated with BMI, while fatigue and NTP showed a trend of significance. Neumann et al. (24) evaluated the relationship between BMI and tenderness measurement, QoL and physical functioning in 100 FS patients. In this study, BMI was negatively related with QoL and tenderness threshold and positively related with physical functioning and tender point count. In our study, we found that QoL assessments were poor in obese FS patients and obese FS patients displayed higher pain sensitivity. FS is also a syndrome of central sensitization and augmentation that results in widespread musculoskeletal tenderness and pain. Tenderness in FS is related to central sensitization with amplification of nociception, resulting in a broad array of stimuli perceived as being more painful among FS patients than healthy controls. This is a basic abnormality that is very likely related to the cause of FS. (8,25) Therefore, we found that TMS was lower in obese FS patients than overweight and normoweight FS patients. Also, we found that WPI was found associated with body fat percentage. It is obvious that generalized pain sensitivity is associated with body fat percentage and increased disease duration may augment central sensitization. Another factor contributing to this augmentation may be the chronic pain emerging from excessive weight load on joints and soft tissues in obesity.
To our knowledge, three studies have been conducted to evaluate body composition in patients with FS. Arranz et al. (1) directly evaluated the relationship between BMI, FM and FFM with short form-36 QoL scores in FS patients. They found that BMI had a negative correlation with emotional role, FM with pain and FFM almost with all scores but specifically with emotional role, vitality and physical role. Collado-Mateo et al. (5) investigated fear of falling in FS patients. They also evaluated body composition in FS patients. They found that body composition and BMI were not different between FS and healthy controls. Lowe et al. (6) evaluated the resting metabolic rates in FS patients. They also investigated the FM, FFM and body fat percentage parameters. They did not find any difference between FS patients and controls on anthropometric measures with the exception of basal body temperature and they also showed that resting metabolic rate values did not correlate with any measure of FS status. They also stated that a low resting metabolic rate is a major risk factor for obesity. In all studies mentioned above, body composition was measured using bioelectric impedance analyzer in patients with FS. To the best of our knowledge, ours is the first study using skinfold method for determining body composition in FS. We think that skinfold method is a simple, cheap and useful method in daily clinical practice.
A large, worldwide INTERHEART study (effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries) suggests that WHR may provide the best anthropometric measure to estimate abdominal fat that predicts cardiovascular morbidity. (26) Loevinger et al. (27) evaluated the metabolic syndrome in females with chronic pain. In their study, FS was found related with larger WC and higher WHR than healthy controls. They found that females with chronic pain from fibromyalgia are at increased risk for metabolic syndrome. Metabolic syndrome indicated risk for cardiovascular disease, diabetes mellitus and all cause of mortality. Similarly, we found that obese or non-obese FS patients had higher cardiovascular risk than healthy control according to WHR and body fat percentage values.
One of the limitations of our study was its small sample size. Another limitation was the lack of evaluating body composition with ultrasonography, dual-energy X-ray absorptiometry or bioimpedance analysis. However, we think that skinfold method is convenient for determining body composition in FS and can be used in clinical practice efficiently.
In conclusion, overweight and obesity are substantial health problems coexisting with FS. Our results showed that obesity increased disease severity in patients with FS. Obese patients with FS had poor QoL. Additionally, long disease duration may be responsible for the poor outcome in obese FS patients with FS. Thus, we think that obesity should be treated and physical activity should be encouraged in the early stages of obesity for a healthy life outcome in patients with FS.
Declaration of conflicting interests
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.
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Mehmet Onat CAKIT,  Burcu Duyur CAKIT,  Hakan GENC,  Secil PERVANE VURAL,  Hatice Rana ERDEM,  Meryem SARACOGLU,  Aynur KARAGOZ 
 Department of Family Medicine, Ankara Training and Research Hospital, Ankara, Turkey
 Department of Physical Medicine and Rehabilitation, Ankara Training and Research Hospital, Ankara, Turkey
 Department of Physical Medicine and Rehabilitation, Medical Faculty of Ahi Evran University, Kirsehir, Turkey
Received: August 22, 2016 Accepted: March 02, 2017 Published online: June 05, 2017
Correspondence: SeCil Pervane Vural, MD. Ankara Egitim ve Arastirma Hastanesi Fiziksel Tip ve Rehabilitasyon Klinigi, 06340 Altindag, Ankara, Turkey.
Tel: +90 532-385 69 88 e-mail: email@example.com
Table 1. Patient characteristics Obese FS patients (n=42) n % Mean [+ or -] SD Median Min- Max Age (year) 48.8 [+ or -] 11.6 Body Mass Index 39.8 [+ or -] 5.7 (kg/[m.sup.2]) Disease duration 34.3 [+ or -] 20.5 * (month) Hand grip strength 24.4 [+ or -] 5.9 * (kg) Control point score 25.2 [+ or -] 5.5 * Total myalgic score 49.9 [+ or -] 9.6 Pain pressure 2.7 [+ or -] 0.5 threshold (kg/[cm.sup.2]) Sleep difficulties 21 50 Neck Pain VAS 7 3-9 Low Back Pain VAS 7 5-10 General VAS 7 5-9 Symptom severity 7 5-10 Widespread Pain 15 10-19 Index Number of tender 18 14-18 point Health assessment 1.3 [+ or -] 1.3 questionnaire Beck Depression 26.6 [+ or -] 10.6 Inventory Overweight FS patients (n=27) n % Mean [+ or -] SD Median Min- Max Age (year) 47.3 [+ or -] 3.4 Body Mass Index 27.0 [+ or -] 1.4 (kg/[m.sup.2]) Disease duration 25.1 [+ or -] 17.4 (month) Hand grip strength 27.9 [+ or -] 6.5 (kg) Control point score 30.1 [+ or -] 8.8 Total myalgic score 53.9 [+ or -] 17.4 Pain pressure 2.7 [+ or -] 0.2 threshold (kg/[cm.sup.2]) Sleep difficulties 19 32.2 Neck Pain VAS 4.5 0-8 Low Back Pain VAS 7.3 0-9 General VAS 6 0-7.2 Symptom severity 5 5-9 Widespread Pain 11 7-13 Index Number of tender 16 11-18 point Health assessment 1.0 [+ or -] 1.1 questionnaire Beck Depression 25.7 [+ or -] 9.0 Inventory Normoweight FS patients (n=32) n % Mean [+ or -] SD Median Min- Max Age (year) 47.1 [+ or -] 7.8 Body Mass Index 22.6 [+ or -] 1.9 (kg/[m.sup.2]) Disease duration 26.4 [+ or -] 17.9 (month) Hand grip strength 27.4 [+ or -] 5.6 (kg) Control point score 30.5 [+ or -] 8.4 Total myalgic score 57.8 [+ or -] 16.1 Pain pressure 2.7 [+ or -] 0.6 threshold (kg/[cm.sup.2]) Sleep difficulties 2 10 Neck Pain VAS 4.7 0-7.1 Low Back Pain VAS 5 0-8 * General VAS 4 0-7.2 Symptom severity 5 5-8 Widespread Pain 8 7-13 Index Number of tender 16 14-18 point Health assessment 0.8 [+ or -] 0.3 questionnaire Beck Depression 27.4 [+ or -] 11.9 Inventory p Age (year) Body Mass Index >0.05 (kg/[m.sup.2]) <0.001 Disease duration (month) 0.034 * Hand grip strength (kg) 0.042 * Control point score Total myalgic score 0.029 * Pain pressure 0.0481 threshold >0.05 (kg/[cm.sup.2]) Sleep difficulties Neck Pain VAS >0.05 Low Back Pain VAS <0.001 General VAS <0.001 <0.01 *, ([dagger]) Symptom severity >0.05f 0.015* 0.0031 Widespread Pain >0.05f Index <0.001 *, ([dagger]) Number of tender >0.05f point <0.001 Health assessment questionnaire 0.012 * Beck Depression Inventory >0.05 FS: Fibromyalgia syndrome; SD: Standard deviation; Min: Minimum; Max: Maximum; VAS: Visual analog scale (0-10); * Group obese-overweight; ([dagger]) Group obese-normoweight; Group overweight-normoweight. Table 2. Anthropometric data of patients Obese FS patients (n=42) n % Mean [+ or -] SD Waist circumference (cm) 124.1 [+ or -] 10.1 No risk (<80) -- -- Medium risk (80-87) 1 -- High risk (>88) 41 -- Hip circumference (cm) 126.6 [+ or -] 8.1 Waist/Hip Ratio 0.9 [+ or -] 0.1 No risk (<0.80) - -- Medium risk (0.81-0.85) 4 -- High risk (>0.85) 41 -- Fat free mass 50.7 [+ or -] 7.9 Fat mass 46.5 [+ or -] 8.9 Body fat percentage 49.1 [+ or -] 2.8 Overweight FS patients (n=27) n % Mean [+ or -] SD Waist circumference (cm) 90.7 [+ or -] 7.5 No risk (<80) 2 7.4 Medium risk (80-87) 8 29.6 High risk (>88) 17 63 Hip circumference (cm) 100.0 [+ or -] 5.0 Waist/Hip Ratio 0.9 [+ or -] 0.09 No risk (<0.80) 2 Medium risk (0.81-0.85) 6 High risk (>0.85) 19 Fat free mass 46.2 [+ or -] 3.0 Fat mass 27.8 [+ or -] 1.4 Body fat percentage 35.3 [+ or -] 1.2 Normoweight FS patients (n=32) n % Mean [+ or -] SD Waist circumference (cm) 78.6 [+ or -] 6.8 No risk (<80) 18 56.3 Medium risk (80-87) 12 37.5 High risk (>88) 2 6.3 Hip circumference (cm) 99.2 [+ or -] 6.2 Waist/Hip Ratio 0.7 [+ or -] 0.1 No risk (<0.80) 18 Medium risk (0.81-0.85) 10 High risk (>0.85) 4 Fat free mass 46.6 [+ or -] 2.5 Fat mass 23.1 [+ or -] 1.9 Body fat percentage 30.8 [+ or -] 1.3 p Waist circumference (cm) <0.001 No risk (<80) Medium risk (80-87) <0.001 * High risk (>88) Hip circumference (cm) <0.001 ([dagger]), (double dagger]) Waist/Hip Ratio <0.001 No risk (<0.80) Medium risk (0.81-0.85) <0.001 * High risk (>0.85) Fat free mass 0.005t Fat mass <0.001 Body fat percentage <0.001 FS: Fibromyalgia syndrome; SD: Standard deviation; * Chi- square test; t Group obese-overweight; ([dagger]) Group obese-normoweight; c: Group overweight-normoweight.
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|Title Annotation:||ORIGINAL ARTICLE|
|Author:||Cakit, Mehmet Onat; Cakit, Burcu Duyur; Genc, Hakan; Vural, Secil Pervane; Erdem, Hatice Rana; Sarac|
|Publication:||Archives of Rheumatology|
|Date:||Mar 1, 2018|
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