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Takeda advances TAK-438 into Phase III studies for treatment of acid-related diseases.

M2 PHARMA-September 19, 2011-Takeda advances TAK-438 into Phase III studies for treatment of acid-related diseases(C)2011 M2 COMMUNICATIONS

19 September 2011 - Japanese Takeda Pharmaceutical Company Limited (TYO:4502) said last Friday it had advanced TAK-438 into Phase III studies in Japan for the treatment of patients with acid-related diseases such as reflux esophagitis.

TAK-438, originated by Takeda, is a potassium-competitive acid blocker (P-CAB) that suppresses gastric acid secretion by inhibiting the binding of potassium ion (K+) to H+, K+-ATPase (proton pomp). It has a different mechanism of action from proton pump inhibitors (PPIs), the company added.

TAK-438 is anticipated to have, in clinical use, a more potent inhibitory effect on gastric acid secretion, a faster onset of action, and a longer lasting effect than PPIs, Takeda said.

The Phase III trials in Japan are multi-centric, and designed to assess the safety and efficacy of TAK-438 for diseases such as gastric ulcer, duodenal ulcer and reflux esophagitis.

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Publication:M2 Pharma
Geographic Code:9THAI
Date:Sep 19, 2011
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