Printer Friendly

TITANIUM MESH VERSUS AUTOLOGOUS BONE GRAFT CRANIOPLASTY.

Byline: Babar Shamim, Awais Ali Khan, Muhammad Junaid Mushtaq, Amjad Saeed Abbassi, Ali Ahmed and Maria Shahzadi

Keywords: Autologous bone graft, Abscess formation, Cranioplasty, titanium mesh, Post-op pain, Seroma formation.

INTRODUCTION

Cranioplasty is a surgical procedure that repairs a defects and deformity of the skulls. In this surgical procedure cranial vault defect is restored following decompressive craniectomy carried out for traumatic brain injury, ischemic or haemorrhagic disease, and after removal of cranial tumours. Apparently a simple, easy and routine surgical procedure, cranioplasty is associated with a high complication rates, reported in 41% of cases1. In addition, 25-76% cranioplasty patients require additional surgical procedures to correct these complications, with a mortality rate over 3% of cases2,3. Most common complications include post-op infections, autologous bone flap resorption, and hematoma/seroma formation.

Other possible complications are wound dehiscence, seizures, hygroma, and poor cosmetic results4. Complications associated with cranioplasty depends on many factors including duration between bone decompression and cranial reconstruction, materials used for reconstruction, experience of the surgeon, age and conditions of patients5,6. Complications after cranioplasty are more frequent in male and old patients6,7, however some complications may result from cranial locations that are convex like sub-occipital and bi-frontal cranium7,8. Cranial defects can be closed using different materials including natural material, like the skull bone of the patient(autologous bone graft), or alloplastic materials, like ceramics, acrylic resin(poly methyl methacrylate), titanium, and others etc. Job Janszoon van Meekeren, in 1668 used canine bone to repair a cranial defect in a Russian man9.

The next advance in cranioplasty in took place the late 19th Century with experimental ground breaking work in bone grafting leading to autografts that became popular in the early 20th Century for cranioplasty. Twentieth Century wars leading to head injuries, among other, provided impetus to search for alternative metals and plastics to cover large cranial defects. Poly methyl methacrylate(PMMA) was introduced in 1940, and is still the most common material used today for this purpose. Research in cranioplasty was then directed at improving the ability of the host to regenerate bone using titanium plates and in 2014, a team of surgeons at Johns Hopkins introduced pericranial-onlay cranioplasty to improve outcomes and minimize complications with cranial surgeries10.

The objective of this study was to compare the efficacy of Titanium Mesh(TM) to Autologous Bone Grafting in cranioplasty and assess seroma, abscess and pain at post-op phase. Since Neurosurgery Ward, Combined Military Hospital, Rawalpindi serves as tertiary care center for military personnel and civilians from Rawalpindi, Islamabad, Northern areas and AJK, Pakistan, an assessment of cranioplasty types need to be carried out that would determine effective, efficient, and resource-saving protocol for patient care and management.

METHODOLOGY

This comparative cross-sectional study was conducted in the department of neurosurgery Combined Military Hospital Rawalpindi from Aug 2017 to Dec 2018. A total of 40 patients with twenty-one male and 19 female patients between the ages of 20 to 60 years received craniotomy for traumatic brain injury(TBI) were included in the study. Patients having chronic diseases like diabetes mellitus, chronic renal failure, bleeding disorders, immuno-compromised, pregnancy and ischemic heart diseases were not included in the study. Permission from hospital ethics committee was obtained, and a written informed consent was taken from all patients included in the study. Twenty patients(Women=12, Men= 8) randomly were assigned to titenium mesh group and 20 patients(Women=7, Men=13) to autologous bone graftgroup.

Hospital registration number, name, age, gender, address and phone number(optional) were noted, and this information was kept confidential under lock and key with the principal investigator. General anesthesia was given to all the patients through Fentanyl, Propofol and Atracurium with dosage adjusted according to the weight of patient. Anesthesia was maintained with mixture of air, oxygen and Sevoflurane. Cranioplasty was done using Titanium Mesh for the titenium mesh group and autologous bone graft cranioplasty for the autologous bone graft group. All surgeries were performed by the same Neurosurgical team. Parenteral postoperative analgesia was given intravenously through Ketorolac(30mg) 8 hourly for 48 hours; and to control for post-op infection, intravenous Ceftriaxone(1g) 12 hourly was given for five days to both groups and were kept in hospital for at least seven days.

Postoperative(Post-op) pain was assessed and scored in both the groups using a visual analogue scale with 10mm line as point rating scale from 0-10, where 0 meant no pain and 10 as highest level of pain. This measurement was carried out at post-op day 3 and 7, where a score of 4 was considered significantly painful. In addition, we recorded pain for patients that required analgesics on day 3 and 7. Seroma was assessed on post-op day 3, and abscess on day 5. Patients were examined approximately after 14 days for a follow-up. All data was analysed by Statistical Package for Social Sciences(SPSS) version 14.

RESULTS

Twenty patients(Women=12, Men=8) were randomly assigned to Titanium Mesh(TM) group(Mage 35.6 +- 3.9 years) and 20 patients(Women=7, Men=13) to Autologous Bone Graft(ABG) group(Mage 37.2 +- 2.9 years). Comparison of pain on day 3 showed seven(35%) patients in titenium mesh group experienced pain compared to 14(70%) patients in the autologous bone graft group, which was statistically significant(p<0.001) as depicted in table.

Similarly, a comparison on day 7, revealed that pain in the titenium mesh group reduced to five(25%) patients compared to 11 patients(55%) patients in the autologous bone graft group, which again was statistically significant(p<0.001) as shown in table. Four(20%) patients in titenium mesh group and 7(35%) patients in autologous bone graft group developed seroma on day 3 and the difference was significant(p<0.001) as in table. Two(10%) patients in titenium mesh group and five(25%) patients in autologous bone graftgroup developed abscess, which was significantly different(p<0.001) as illustrated in table.

Table: Titanium mesh versus autologous bone graft cranioplasty.

Parameters###Titanium###Autologous###p-

###Mesh Group###Bone Graft###value

###Group

Age###35.6 +- 3.9 37.2 +- 2.9###-

###M-8(40%)###M-7(35%)

Gender###-

###F-12(60%)###F-13(65%)

Pain on###+ve 7(35%) +ve 6(30%)

###<0.001

Day 03###-ve 13(65%) -ve 14(70%)

Pain on###+ve 5(25%) +ve 11(55%)

###<0.001

Day 07###-ve 15(75%) -ve 9(45%)

Analgesic

###+ve 7(35%) +ve 14(70%)

Needed at###<0.001

###-ve 13(65%) -ve 6(30%)

Day 3

Analgesic

###+ve 5(25%) +ve 11(55%)

Needed at###<0.001

###-ve 15(75%) -ve 9(45%)

Day 7

Seroma###+ve 4(20%) +ve 7(35%)

###<0.001

Formation###-ve 16(80%) -ve 13(65%)

Abscess###+ve 2(10%) +ve 5(25%)

###<0.001

Formation###-ve 18(90%) -ve 15(75%)

DISCUSSION

In many patients with severe neurological conditions, decompressive craniotomy serves as a life-saving procedure and requires bone closure either through bone flap replacement or its reconstruction with cranioplasty11. Cranial reconstruction provides protection to the underlying brain, improves neurological function by recovering cerebrospinal fluid(CSF) dynamics and cerebral blood flow, and cosmetically restore cranial contour11,12.

Cranioplasty seems like an easy and routine surgical procedure, but it is a high risk surgical procedure due to a high complication rate13. There are multiple factors which affect the outcome of the procedure for exampletime spent between decompression and reconstruction, implants/materials used for reconstruction, experience of the surgeon on cranial reconstruction, age and conditions of patients14. Complications associated with cranial reconstruction are high as compared to a routine neurosurgical operation e.g 15-41% versus 2-5%15. Moreover, another intervention may be required in 25-76% of patients with cranioplasty complications to correct the complications, which ultimately increase the mortality by over 3%. Complication rate is more in males and in elderly age group16.

Rate of complication also depends upon the site of cranium i.e. whether the procedure has been performed on the convex surface, suboccipital region and bifrontal cranial region17. The most common complications associated with cranioplasty are infections, bone resorption, wound dehiscence, hematoma/seroma collection, seizu-res, hygromas and poor cosmetic results18,19.

Brommel and et al in 2015 have demonstrated that surgical site infection(SSI) and bone flap resorption(BFR) were the two most common complications, affecting 8(9.2%) and 14(19.7%) patients, respectively following cranioplasty using bone grafting which can be compared to our results where 25% developed abscess postoperatively. Mukherjee et al, in 2014 demonstrated that titanium cranioplasty hashigh complication rate i.e. 26.4% as compared to our study(10%) and the plate removal rate was 10.3%. The commonest complication was infection, which accounted for 69% of plate removals20. We have compared the outcome of cranioplasty using bone grafting and titanium mesh in terms of complications like pain, seroma formation and abscess formation. Results of our study show that the patients will have more pain and increased chances of seroma and abscess formation if bone grafting is used to close the defect, making titanium mesh usage superior to it.

CONCLUSION

Cranioplasty using titanium mesh is superior to autologous bone grafting as it has less complication rate in terms of pain, seroma and abscess formation. So, its usage in future will decrease the burden on health budget by decreasing the complication rate.

CONFLICT OF INTEREST

This study has no conflict of interest to be declared by any author.

REFERENCES

1. Brommeland T, Rydning PN, Pripp AH, Helseth E. Cranioplasty complications and risk factors associated with bone flap resorption. Scand J Trauma Res Emerg Med 2015; 23(1): 75-80.

2. Liang FS, Tipper G, Hunt L, Gan PYC. Cranioplasty outcomes and associated complications: a single-center observational study. Br J Neurosurg 2016; 30(1): 122-27.

3. Joswig H, Gautschi OP, El Rahal A, Sveikata L, Bartoli A, Hildebrandt G, et al. Cranioplasty: Is surgical education safe? World Neur 2016; 91(1): 81-88.

4. Hall WA. Cranioplasty Infections-Adding Insult to Injury. World Neur 2014; 82(1): E435-37.

5. SPSS Inc.(2005). SPSS Base 14.0 user's guide and CD ROM. Prentice Hall.

6. Gooch MR, Gin GE, Kenning TJ, German JW. Complications of cranioplasty following decompressive craniectomy: analysis of 62 cases Neur Focus 2009; 26(1): E9-15.

7. Godil SS, Shamim MS, Enam SA, Qidwai U, Qadeer M, Sobani ZA. Cranial reconstruction after decompressive craniectomy: prediction of complications using fuzzy logic. J Craniofac Surg 2011; 22(4): 1307-11.

8. Zanaty M, Chalouhi N, Starke RM, Clark SW, Bovenzi CD, Saigh M, et al. Complications following cranioplasty: incidence and predictors in 348 cases. J Neur 2015; 123(1): 182-88.

9. Bobinski L, Koskinen LOD, Lindvall P. Complications following cranioplasty using autologous bone or polymethymethacrylateRetrospective experience from a single center. Clin Neurol Neur 2013; 115(1): 1788-91.

10. Coulter IC, Pesic-Smith JD, Cato-Addison WB, Khan SA, Thompson DT, Jenkins AJ, et al. Routine but risky: A multicentre analysis of outcomes of cranioplasty in the Northeast of England. Acta Neur 2014; 156(1): 1361-68.

11. Klinger DR, Madden C, Beshay J, White J, Gambrel K, Rickert K.Autologous and Acrylic Cranioplasty: a review of 10 years and 258 cases. World Neur 2014; 82(1): E525-30.

12. Wachter D, Reineke K, Behm T. Cranioplasty after decompressive hemicraniectomy: Understimatedd surgery-associated complications? Clin Neurol Neur 2013; 115(1): 1293-97.

13. Honeybull S, Ho KM. Long term complications of decompressive craniectomy for head injury. J Neur 2011; 28(1): 929-35.

14..Honeybull S, Morrison DA, Ho K, Wiggins A, Janzen C, Kruger K. Complications and consent following decompressive craniectomy: An illustrative case study. Brain Injury 2013; 27(1): 1732-36.

15. Lee L, Ker J, Quah BL, Chou N, Choy D, Yeo TT. A retrospective analysis and review of an institution's experience with the complications of cranioplasty. Br J Neur 2013; 27(1): 629-35.

16. Yadla S, Campbell PG, Chitale R, Maltenfort MG, Jabbour P, Sharan AD. Effect of early surgery, material, and method of Flap preservation on Cranioplasty Infections: A systemic review. Neuro 2011; 68(1): 1124-30.

17. Walcott BP, Kwon CS, Sheth S, Fehnel CR, Koffie RM, Asaad WF, et al. Predictors of cranioplasty complications in stroke and trauma patients. J Neur 2013; 118(1): 757-62.

18. Fischer CM, Burkhardt JK, Sarnthein J, Bernays RL, Bozinov O. Aesthetic outcome in patients after polymethyl-methacrylate(PMMA) cranioplasty-A questionnaire-based single-centre study. Neurol Res 2012; 34(3): 281-85.

19. Kwiecien GJ, Rueda S, Hashem A. Long-term Outcomes of Cranioplasty: Titanium Mesh Is Not a Long-term Solution in High-risk Patients. Ann Plast Surg 2018; 81(4): 416-22.

20. Mukherjee S, Thakur B, Haq I, Hettige S, Martin AJ. Complications of titanium cranioplasty-A retrospective analysis of 174 patients. Acta Neur(Wien) 2014; 156(5): 989-98.
COPYRIGHT 2020 Knowledge Bylanes
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2020 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Author:Babar Shamim, Awais Ali Khan, Muhammad Junaid Mushtaq, Amjad Saeed Abbassi, Ali Ahmed and Maria Shah
Publication:Pakistan Armed Forces Medical Journal
Geographic Code:9PAKI
Date:Aug 31, 2020
Words:2294
Previous Article:PATIENTS' AWARENESS AND PREFERENCE FOR BONE GRAFTS USED IN ORAL SURGERY.
Next Article:IMPACT OF VITAMIN D3, ON HBA1C IN INDIVIDUALS WITH PRE-DIABETES.
Topics:

Terms of use | Privacy policy | Copyright © 2022 Farlex, Inc. | Feedback | For webmasters |