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THIRD PATENT IN THREE MONTHS ISSUED FOR METHOD OF RAPIDLY RESETTING BODY CLOCK

 BRAINTREE, Mass., Jan. 8 /PRNewswire/ -- Light Sciences, Inc. today announced that a third patent was issued this week covering a method of rapidly shifting an individual's circadian rhythm to a pre-determined schedule. The U.S. Patent & Trademark Office issued patent number 5,176,133 to Brigham and Women's Hospital, Boston, which has licensed the technology to Light Sciences, Inc.
 The latest patent protects a process of shifting an individual's circadian cycle by reducing their endogenous phase amplitude to zero over a period of less than 24 hours. By bringing an individual's amplitude to zero, body clock shifts can be made in dramatically short periods of time.
 Amplitude refers to the body's metabolism rate, which increases and decreases at varying times of day.
 According to Dr. Theodore L. Baker, vice president of Scientific Applications for Light Sciences, Inc., "These three patents protect a proven method for predictably shifting an individual's circadian rhythm. It should prove extremely useful to shift workers, military applications, sufferers of jet lag, and the elderly, who often have trouble sleeping through the night due to the misalignment of the body clock. Because this technique works quickly, is non-drug and non- invasive, it is an appealing solution to the fatigue associated with an out-of-sync body clock."
 The first patent, issued to Brigham and Women's Hospital on Nov. 17, 1992, protects shifting an individual's body clock utilizing a method of assessing the amplitude of an individual, and applying light and darkness to cause a change in the cycle. The second patent, issued on Dec. 1, 1992, covers a method of shifting the body clock with exposure to light and darkness using complex mathematical equations. The equations determine the timing and intensity of light needed to cause a specific shift in the body clock.
 The newest patent, issued on Jan. 5, 1993, protects the fastest known method for shifting an individual's body clock. A shift of two to three hours can be made in one day, and up to eight to ten hours in two days, by reducing the circadian amplitude of an individual to zero and providing carefully timed light and darkness.
 The circadian cycle is a self-sustained biological rhythm driven by an internal biological clock and synchronized to a 24-hour day. Research has established that light and darkness is the most potent daily synchronizer of this cycle.
 Light Sciences, Inc. has acquired the worldwide rights for this technology from Brigham and Women's Hospital. The company is currently under contract with NASA to provide light schedules for adaptation of Space Shuttle Astronauts prior to launch. The company also has instituted two trials at major industrial facilities in the United States, using its LSI Circadian Light System to help workers on rotating shift schedules better adapt.
 Patent inventors are Charles A. Czeisler, Ph.D., M.D., Director of Circadian and Sleep Disorders Medicine, Brigham and Women's Hospital and Associate Professor of Medicine, Harvard Medical School; Richard E. Kronauer, Ph.D., Gordon McKay Professor of Applied Sciences at Harvard Medical School; and James S. Allan, M.D., Clinical Fellow, Harvard Medical School.
 -0- 1/8/93
 /CONTACT: Matthew Weisman, president of Light Sciences, Inc., 617-849-8226, or Brad Miles of Ted Klein & Co., 212-477-9007, for LSI/


CO: Light Sciences, Inc. ST: Massachusetts IN: MTC SU:

LR-OS -- NY025 -- 3033 01/08/93 12:27 EST
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Date:Jan 8, 1993
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