Printer Friendly

THE SPECTRUM OF RADIOLOGICAL FINDINGS IN PATIENTS PRESENTING WITH DIFFERENT CLINICAL INDICATIONS FOR CRANIAL COMPUTED TOMOGRAPHIC SCAN.

Byline: Hussain Rashid Ihsan, Salman Ahmad and Saeed Bin Ayaz

Keywords: Brain pathologies, Computed tomography scan, Skull pathologies.

INTRODUCTION

Computed Tomography (CT) scan is a radiological modality that makes use of computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional (tomographic) images (often called slices) of specific areas of a scanned object, allowing the user to see inside of the object without cutting. Digital geometry processing is used to generate a three-dimensional image of inside of the object from a large series of two-dimensional radiographic images taken around a single axis of rotation. The CT Scan is the investigation of choice in many clinical problems to identify the primary pathology and guide the management process.

In the modern era, CT scan is the modality of choice in initial assessment of many neurological emergencies, as it is widely available, faster, and highly accurate in detection of skull fractures and acute intracranial haemorrhage1. CT scan is also the primary modality to detect ischemic or haemorrhagic nature of a stroke2. In cases of migraines, headaches, and loss of consciousness, CT scan is helpful in identifying the under-lying pathology as it can detect brain tumours, abscess, hydrocephalus, sinus blockage, cerebrovascular accidents, vascular malformation, and haemorrhages, etc3.

CT scan is the first-line imaging modality for the investigation of acute neurological emergencies because it is fast and readily and widely available. Image findings, in combination with Glasgow Coma Scale can be used to classify the severity of the neurological issues and guide the treatment in the right direction. In fact, we have observed a positive CT scan, identifying abnormalities related to the expected pathology in 80.3% of the referred cases. In the literature, the incidence of abnormal CT scan findings has been quite variable and has ranged from 37% to 100%1,4-7. The chances of getting an abnormality on CT scan was found to be directly related to the severity of clinical symptoms8.

The studies regarding the pattern of pathologies seen on CT scan are lacking in Azad Jammu and Kashmir. This study was aimed at identifying the main reasons for seeking CT scan evaluation and brain and skull pathologies seen on CT scan films in patients referred for such evaluation. Association of traumatic vs non-traumatic etiologies with age and gender and percentage of negative and positive CT scans for a particular referring reason were secondary goals.

MATERIAL AND METHODS

It was a cross-sectional study carried out at Sheikh Khalid Bin Zaid Al-Nahyan Hospital (SKBZH), Muzaffarabad. After approval from the hospital ethical review committee of SKBZH, we sampled 145 patients who were referred from various departments of SKBZH for radiological evaluation of skull and brain using CT scan through consecutive sampling from January to September 2016. The patients with already diagnosed status epilepticus, carcinoid tumours, and other neoplastic lesions of the brain, and history of a psychiatric disorder were not included in the study. The study was performed by a senior CT scan technologist. All studies were performed using CT scan machine Brilliance CT 16 slice - DS (Koninklijke Philips Electronics, Naamloze vennootschap, The Netherlands). In all patients, 0.5 mm slices were taken. All reports were studied and reported by a consultant radiologist.

All the data were analysed using statistical program Statistical Package for Social Sciences (SPSS) version 20.0 (IBM Corp., Armonk, NY, USA). For the analysis of association of traumatic vs non-traumatic etiologies with age, the sample was divided into two groups i.e. age a$?36 years and age >36 years. Means and standard devia-tions were calculated for age. Frequencies and percentages were calculated for gender, the reasons for the referral, age-groups, and radiological finding on CT scan. The odds ratio was calculated for gender association with traumatic vs non-traumatic etiologies, while Chi-square test was applied for the association of age-group with traumatic vs non-traumatic etiologies. A p-value less than 0.05 was considered significant.

Table-I: The demographic and clinical characteristics of the sample.

Characteristics###n(%)###Characteristics###n(%)

Gender###CT Scan Evaluation

Male###86(62.8)###Normal###27(19.7)

Female###51(37.2)###Abnormality###110(80.3)

Primary reason for referral###Abnormality seen on CT scan

Head trauma###84(61.3)###Fracture of the skull bones###51(46.4)

Generalized or localized weakness###25(18.2)###Extradural hematoma###17(15.4)

Loss of consciousness###17(12.4)###Cerebral infarct###16(14.5)

Headache###5(3.6)###Intracerebral hemorrhage###15(13.6)

Epilepsy###3(2.2)###Subdural hematoma###14(12.7)

Speech abnormality###3(2.2)###Brain contusions###12(10.9)

###Scalp hematoma###9(8.2)

###Age related cerebral atrophy###8(7.3)

###Subarachnoid hemorrhage###8(7.3)

###Hemosinus###8(7.3)

###Hydrocephalus###6(5.4)

###Deep white tissue ischemic changes###6(5.4)

###Sinusitis###4(3.6)

###Dural sinus thrombosis###3(2.7)

###Diffuse brain swelling###2(1.8)

Table-II: Association of traumatic vs non-traumatic etiology and age-groups.

Age group###Traumatic vs non-traumatic etiology

###Traumatic etiology###Non-traumatic etiology

###n(%)###n(%)

Age a$?36 years###49(74.2)###9(24.3)

Age >36 years###17(25.8)###28(75.7)

Table-III: Correlation between clinical questions and computed tomography results.

Clinical questions###Total###Negative CT Scan###Positive CT Scan

###n(%)###n(%)###n(%)

Head trauma###84(61.3)###17(20.2)###67(79.8)

Generalized or localized weakness###25(18.2)###1(4)###24(96%)

Loss of consciousness###17(12.4)###6(35.3)###11(64.7)

Headache###5(3.6)###2(40)###3(60)

Epilepsy###3(2.2)###1(33.3)###2(66.7)

Speech abnormality###3(2.2)###0###3(100)

RESULTS

Out of a total of 137 individuals finally included, 86 (62.8%) were male and 51 (37.2) were female. The mean age of the sample was 34 +- 23 years with a range of 2-85 years. Fifty-eight individuals were a$?36 years of age, while fortyfive individuals were >36 years of age (56.3% and 43.7% respectively after eliminating thirty-four missed entries). The majority (61.3%, n=84) of the individuals were referred for the radiological evaluation by CT scan for the complaints of head trauma (table-I). The head trauma was significantly more common in the age-group of a$?36 years, while non-traumatic complaints were more common in the age-group of >36 years (p<0.001) (table-II). The males were more commonly involved in head trauma than females (Male-to-female ratio of 2:1, Odds ratio: 1.53, Confidence interval: 0.76-3.11) (fig-1).

On CT scan evaluation, 19.7% (n=27) had a normal study while 80.3% (n=110) had at least one abnormal finding. Fracture of the skull bones (with or without other abnormalities) was found in 46.4% (n=51) patients. Sixty-seven (79.8%) individuals with a history of head trauma showed an abnormal pathology on CT scan related to trauma. The common abnormalities other than the fracture were extradural hematoma (n=17), cerebral infarct (n=16), intracerebral haemorrhage (n=15), and subdural hematoma (n=14) (table-I). The correlation between clinical questions and CT scan results is shown in table-III.

DISCUSSION

We observed that the majority of individuals were referred for the radiological evaluation by CT scan for the complaints of head trauma. The cases of head trauma are increasing worldwide due to increased incidence of motor vehicle accidents (MVA) and acts of violence. Head trauma and the related traumatic brain injury is more common in persons younger than 35 years and the male-to-female ratio is nearly 2:19. We found a similar trend as head trauma was significantly more common in the age-groups of a$?36 years and male-to-female ratio was exactly 2:1. The apparent reason for male gender predominance appears to be greater participation of males in the outdoor activities. The social and cultural values in many countries entail male population to be more involved in work, sports, and other outdoor activities as compared to the females. Therefore, the exposure to MVA, acts of violence, and environmental calamities is greater among males than females.

CT is the imaging modality of choice for detecting fractures and depending on the type and location of fractures, quick surgical intervention can be done to prevent cerebrospinal fluid leak, infection, thrombosis, infarct or haemorrhage1. The literature shows an incidence of 3.1% to 80% of skull fractures seen radio-logically in cases of acute head trauma1,10-18. We found that 60.7% of individuals with a history of head trauma showed a fracture. While including pathologies related to fracture, this percentage increased to 79.8% and thus facilitated prompt appropriate treatment.

The other common abnormalities seen on CT scan were extradural hematoma (15.4%), cerebral infarct (14.5%), intracerebral haemorrhage (13.6%), subdural hematoma (12.7%), and brain contusions (10.9%). Tomar et al, in an Indian study, found the incidence of extradural hematoma, intracerebral haemorrhage, brain contusion, and subdural hematoma to be 12%, 26%, 22%, and 18% respectively in a sample of 100 patients of head trauma who underwent cranial CT scan1. Imtiaz, in another Indian study found an incidence of 4%, 15%, 43%, and 21% respectively for the above-mentioned CT scan findings in a sample of 100 individuals17. Zimmerman and colleagues, in an American study, found incidence of the abnormalities in the same order as 4.9%, 6.3%, 21.3%, and 12.6% respectively in 286 patients of head trauma16. Hidayat, in an Iraqi study, observed incidence of 16%, 46%, 44%, and 38% respectively for the same findings in the above-mentioned order19.

Lobato et al, in a Spanish study, observed incidence of 13.7%, 31.4%, and 20.2% for extradural hematoma, brain contusions, and subdural hematoma in 277 cases of head injury20.

For other complaints of generalized or localized weakness, loss of consciousness, headache, epilepsy, and speech abnormality, we also found a higher percentage of positive CT scans, which verifies the importance of CT scan evaluation in such abnormalities. The medical literature endorses the usage of CT scan in evaluation, depending upon the clinically observed necessity, of patients with headaches, loss of consciousness, and suspected cerebrovascular accident21-23. However, the literature advises against routine use of CT scan for all patients with new onset nonfebrile seizures24. We suggest that all patients with suspected acute neurological emergency must be evaluated by CT scan examination. Advantages with CT scan evaluation include rapid diagnosis and real-time observation of etiologies that might be lethal to the patient. CT scan decreases the rate of mis-management, hence better care of the patients can be warranted in time.

CONCLUSION

The majority of individuals were referred for the radiological evaluation by CT scan for the complaint of head trauma. Fracture of the skull bones was the commonest abnormality seen on CT scan evaluation. Head trauma was significantly more common in age groups of a$?36 years and males were more commonly involved than females. Higher percentage of positive CT scan was found in patients with all types of presenting complaints. CT scan is a reliable, highly accurate, and sensitive modality in evaluation of patients with acute neurological emergencies. It may clearly outline those patients who require surgery or other form of intervention, so it can provide rapid, effective diagnostic information to guide appropriate clinical management.

CONFLICT OF INTEREST

This study has no conflict of interest to be declared by any author.

REFERENCES

1. Tomar SS, Bhargava A, Reddy N. Significance of computed tomography scans in head injury. Open J Clin Diagn 2013; 3: 109-14.

2. Barber PA, Demchuk AM, Zhang J, Buchan AM. Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. Lancet 2000; 355 (9216): 1670-4. Erratum in: Lancet 2000; 355(9221): 2170.

3. Neurology emergencies. In: Cameron P, Jelinek G, Kelly AM, Brown A, Little M, eds. Textbook of adult emergency medicine, 4th Edn, GB: Elsevier Health Sciences, 2014; pp 368-401.

4. Af-Geijerstam JL, Oredsson S, Britton M, OCTOPUS Study Investigators. Medical outcome after immediate computed tomography or admission for observation in patients with mild head injury: randomised controlled trial. BMJ 2006; 333(7566): 465.

5. Mushtaq S, Bodla MA. Diagnostic accuracy of computed tomography for subarachnoid haemorrhage in patients presenting with thunderclap headache (Lumbar Puncture as Gold Standard). Pak J Med Health Sci 2014; 8(2): 344-6.

6. Sosin DM, Sniezek JE, Thurman DJ. Incidence of mild and moderate brain injury in the United States, 1991. Brain Inj 1996; 10(1): 47-54.

7. Brown AW, Elovic EP, Kothari S, Flanagan SR, Kwasnica C. Congenital and acquired brain injury. Epidemiology, pathophysiology, prognostication, innovative treatments, and prevention. Arch Phys Med Rehabil 2008; 89(3 Suppl-1): S3-8.

8. Diagnosis and treatment of head injury in adults. In: Youmans JR, ed. Neurological Surgery, 3rd Edn, Philadelphia: Saunders, 1990; pp 2017-148.

9. Ainsworth CR, Brown GS. Head Trauma [internet]. Medscape; 2015 [Cited 2017]. Available from: http://emedicine.medscape. com/article/433855-overview#a6.

10. De Lacey G, Barker A, Harper J, Wignall B. An assessment of the clinical effects of reporting accident and emergency radiographs. Br J Radiol 1980; 53(628): 304-9.

11. Arienta C, Caroli M, Balbi S. Management of head-injured patients in the emergency department: a practical protocol. Surg Neurol 1997; 48(3): 213-9.

12. Haydel MJ, Preston CA, Mills TJ, Luber S, Blaudeau E, DeBlieux PM. Indications for computed tomography in patients with minor head injury. N Engl J Med 2000; 343(2): 100-5.

13. Murshid WR. Role of skull radiography in the initial evaluation of minor head injury: A retrospective study. Acta Neurochir (Wien) 1994; 129(1-2): 11-4.

14. Stein SC, Young GS, Talucci RC, Greenbaum BH, Ross SE. Delayed brain injury after head trauma: Significance of coagulopathy. Neurosurgery 1992; 30(2): 160-5.

15. Servadei F, Ciucci G, Morichetti A, Pagano F, Burzi M, Staffa G, et al. Skull fracture as a factor of increased risk in minor head injuries. Indication for a broader use of cerebral computed tomography scanning. Surg Neurol 1988; 30(5): 364-9.

16. Zimmerman RA, Bilaniuk LT, Gennarelli T, Bruce D, Dolinskas C, Uzzell B. Cranial computed tomography in diagnosis and management of acute head trauma. AJR Am J Roentgenol 1978; 131(1): 27-34.

17. Imtiaz AM. Trauma Radiology: Importance of computed tomography scans in acute traumatic brain injury. Int J Pharma Sci Bus Manag 2016; 4(4): 7-15.

18. Servadei F, Faccani G, Roccella P, Seracchioli A, Godano U, Ghadirpour R, et al. Asymptomatic extradural haematomas. Results of a multicenter study of 158 cases in minor head injury. Acta Neurochir (Wien) 1989; 96(1-2): 39-45.

19. Hidayat SK. Acute Head Trauma-CT Scanning Study. Dohuk Med J 2007; 1(1): 78-87.

20. Lobato RD, Cordobes F, Rivas JJ, de la Fuente M, Montero A, Barcena A, et al. Outcome from severe head injury related to the type of intracranial lesion. A computerized tomography study. J Neurosurg 1983; 59(5): 762-74.

21. Hammond N, Ranta A. The yield of head computed tomography in patients with new onset of transient headaches. Intern Med J 2017; 47(10): 1141-46.

22. Chalela JA, Kidwell CS, Nentwich LM, Luby M, Butman JA, Demchuk AM, et al. Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: A prospective comparison. Lancet 2007; 369(9558): 293-8.

23. Halley MK, Silva PD, Foley J, Rodarte A. Loss of consciousness: when to perform computed tomography? Pediatr Crit Care Med 2004; 5(3): 230-3.

24. Maytal J, Krauss JM, Novak G. The role of brain computed tomography in evaluating children with new onset of seizures in the emergency department. Epilepsia 2000; 41(8): 950-4.
COPYRIGHT 2019 Knowledge Bylanes
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2019 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Pakistan Armed Forces Medical Journal
Date:Feb 28, 2019
Words:2780
Previous Article:THE IMPACT OF MINIMAL INVASIVE SURGERY COURSE AND THE BARRIERS FACED BYGENERAL SURGEONS IN ITS IMPLEMENTATION.
Next Article:PREDICTING QUALITY OF LIFE IN HAEMODIALYSIS PATIENTS.
Topics:

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters