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TARGETED GENETICS SIGNS RESEARCH AGREEMENT WITH JOHNS HOPKINS UNIVERSITY

 SEATTLE, Aug. 4 /PRNewswire/ -- Targeted Genetics Corp. (TGC) signed a collaborative research agreement with the Johns Hopkins University School of Medicine (JHUSM) to develop adeno-associated virus (AAV) vectors for in vivo delivery. Under the agreement, TGC will have first option to negotiate an exclusive, worldwide license to any inventions resulting from the collaboration. In return, TGC will make royalty payments to JHUSM.
 According to Barrie J. Carter, Ph.D., TGC executive vice president and director of research and development, "Our collaboration with JHUSM will continue to advance our mission to provide integrated gene therapy treatments for acquired and inherited diseases, and is particularly important in developing AAV vectors for cystic fibrosis."
 Cystic fibrosis (CF) is the most common fatal genetic disease in the United States today. CF is caused by the absence of a protein in the lungs called the CFTR protein. Gene therapy of CF is directed toward delivering CFTR genes into the lungs where the protein can be produced at therapeutic levels.
 AAV vectors are among a small number of recombinant virus vector systems that have been shown to have utility as in vivo gene transfer agents, and thus are potentially of great importance for human gene therapy. "It's our hope that this collaborative effort will speed the process of vector development and preclinical testing, and thus hasten our entry into the clinic with AAV-CFTR vectors," said Carter.
 Carter is world-renowned in the field of AAV vectors and is the inventor of the first AAV vector patent to be issued.
 Targeted Genetics Corp. is a leader in the development of integrated gene therapy treatments for acquired and inherited diseases. Primary targets of the company's development program include AIDS, cystic fibrosis, cytomegalovirus and cancer.
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 /CONTACT: H. Stewart Parker or Alberta L. Garvin of Targeted Genetics Corp., 206-623-7612/


CO: Targeted Genetics; Johns Hopkins University School of Medicine ST: Washington IN: MTC SU:

LM-JH -- SE004 -- 9172 08/04/93 07:51 EDT
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Publication:PR Newswire
Date:Aug 4, 1993
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