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Symptomatic Patent Foramen Ovale with Hemidiaphragm Paralysis.

1. Introduction

In evaluation of a patient with a chief complaint of dyspnea, a potential pitfall would be to neglect rarer etiologies in favor of more common causes. Dyspnea accounts for 28.6% of the admissions to the hospital from Emergency Department (ED), common etiologies being chronic conditions such as Asthma, Heart Failure, and Chronic Obstructive Pulmonary Disease (COPD) [1]. In light of the number of patients visiting the ED with dyspnea-related complaints, it would be easy to overlook the less common cause of dyspnea. This can impact patient outcomes. Less common causes of dyspnea including valvular heart disease, pulmonary embolism, and intracardiac shunt are curable if the proper diagnosis is made in a timely fashion. We present one such case of treatable dyspnea due to patent foramen ovale (PFO) related right-to-left shunt (RLS) in setting of right hemidiaphragm paralysis. Our review of literature revealed only eleven cases with RLS via PFO in presence of right hemidiaphragm (Table 1) [2-10].

2. Case Presentation

59-year-old female with past medical history of long standing primary hypertension, chronic kidney disease Stage III, and Diabetes Mellitus type II started experiencing gradual worsening shortness of breath (SOB) after self-limiting bout of viral pneumonia three months priorly. Her CXR showed right hemidiaphragm elevation that was confirmed with a sniff test (Figure 1).

Detailed pulmonary evaluation for continued SOB also showed moderate COPD and elevated Alveolar-arterial (A-a) gradient on pulmonary function test. Ventilation-Perfusion scan did not show any evidence of pulmonary embolism. Sleep study with apnea-hypopnea index (AHI) of 110 per hour confirmed severe obstructive sleep apnea (OSA) and sleep efficiency of 63.4%.

She was started on continuous positive airway pressure (CPAP) for OSA and on 4 liters/minute (L/min) oxygen via nasal cannula (NC) for continued hypoxia. As part of workup for headaches and hemidiaphragm paralysis, MRI of the brain showed intracranial aneurysm that required craniotomy and clipping. Postoperatively, patient was difficult to extubate due to continued hypoxemia. Therefore, transthoracic echocardiogram (TTE) was performed that showed right-to-left intracardiac shunt on saline bubble study. Transesophageal echocardiogram confirmed a PFO with continuous RLS, normal right ventricle, and right atrium size (Figure 2). Over the next few months, patient required multiple hospitalizations for repeat episodes of SOB presenting to the hospital with oxygen saturations in low 80% despite using continuous 4L/min oxygen via NC therefore requiring high flow oxygen and continuous positive airway pressure (CPAP) to stabilize her. Acute exacerbation episodes were treated with CPAP and diuresis, and these measures would improve the dyspnea but did not alleviate. Due to persistent hypoxia and lifestyle limiting dyspnea despite oxygen supplementation patient was referred for PFO closure. As part of evaluation for hypoxia and PFO, patient underwent right and left heart catheterization (RHC and LHC) that showed normal coronaries, normal pulmonary pressure and resistance, normal LV filling pressure, and femoral artery [O.sub.2] saturation of 87% on room air. After heart team discussion including pulmonologist, percutaneous PFO closure was recommended. Patient underwent successful percutaneous PFO closure using 30 mm Amplatzer Cribriform Septal Occluder (ST Jude Medical). She had immediate improvement in her SOB after PFO closure. She was taken off continuous oxygen after 6-minute walk test prior to discharge. Furosemide requirement reduced from 40 mg oral twice daily to 40 mg oral once daily after PFO closure. Her status is at five years after PFO closure with no hospitalization related to SOB. She is currently NYHA Class II, walks > 300 yards, and performs all the activities of daily life without any limitations.

3. Discussion

In patients with refractory SOB and hypoxia that fails to resolve with oxygen therapy, a physiologic or anatomic RLS should be considered as part of the differential diagnosis. Workup should include echocardiogram with a bubble study and right heart catheterization. Statistically, the most common cause of an interatrial communication is a patent foramen ovale (PFO), present in estimated 20-30% of the adult population [11, 12]. PFO is mostly asymptomatic and functions as a flap-like valve that transiently opens when right atrial pressure gets higher than the left atrial pressure during maneuvers like having bowel movement, coughing, or sneezing. However, a PFO can facilitate a new onset RLS in cases in which the pressure gradient across the atria is reversed (right atrial pressure > left atrial pressure). Conditions such as OSA, COPD, and other causes of pulmonary hypertension (PH) can lead to reversal of atrial pressure. The findings of normal right sided pressures with an accompanying RLS across a PFO appear to be a paradox. In our patient, RHC revealed normal right and left fillings pressures and normal pulmonary artery pressure and resistance, suggesting optimized COPD and OSA treatment, excluding reversal of atrial pressures as mechanism for RLS.

Hypoxemia secondary to RLS with normal pulmonary artery pressure has been extensively documented after right pneumonectomy whereas only few case reports have documented hypoxemia secondary to a RLS through a PFO in the presence of an elevated right hemidiaphragm, which our patient had due to viral pneumonia [11, 12]. We agree with the proposed mechanism by Zanchetta et al. for the paradoxical shunt based on an anatomical and embryological review of the flow dynamics from the inferior vena cava (IVC) into right atrium. Normally, blood enters the right atrium in upward and backward direction from IVC towards the foramen ovale (FO) to avoid collision with blood entering in downward and forward direction from the superior vena cava. In setting of right hemidiaphragm paralysis, blood flow from IVC is further directed towards the FO resulting in RLS through the PFO even in absence of reversed atrial pressures [10, 13]. Therefore, patient may not present with typical platypnea-orthodeoxia symptoms. Presence of exuberant Eustachian valve can also exacerbate the RLS via redirecting the flow towards the PFO in absence of reversed atrial pressures [14].

4. Conclusion

Right-to-left shunting through a PFO can occur due to multiple etiologies that either increase the right atrial pressure, reduce the left atrial pressure, or facilitate the IVC flow to be directed to the PFO. In some patients, PFO related RLS can lead to significant hypoxia and SOB. As in our case, high clinical suspicion and thorough evaluation helped reach the diagnosis of significant RLS via PFO in setting of right hemidiaphragm paralysis. Percutaneous PFO closure led to significant improvement in patient symptoms.

https://doi.org/10.1155/2017/9848696

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References

[1] A. Elixhauser and P Owens, "Reasons for being admitted to the hospital through the emergency department," Agency for Healthcare Research and Quality Statistical Brief #2, 2003, http://www.hcup-us.ahrq.gov/reports/statbriefs/sb2.pdf.

[2] K. D. Murray, L. K. Kalanges, J. E. Weiland et al., "Platypneaorthodeoxia: an unusual indication for surgical closure of a patent foramen ovale," Journal of Cardiac Surgery, vol. 6, no. 1, pp. 62-67,1991.

[3] P. J. Cordero, P. Morales, J. Vallterra et al., "Transient right-to-left shunting through a patent foramen ovale secondary to unilateral diaphragmatic paralysis," Thorax, vol. 49, no. 9, pp. 933-934, 1994.

[4] S. Ghamande, R. Ramsey, J. F. Rhodes, and J. K. Stoller, "Right hemidiaphragmatic elevation with a right-to-left interatrial shunt through a patent foramen ovale: a case report and literature review," CHEST, vol. 120, no. 6, pp. 2094-2096, 2001.

[5] O. D. Lopez Gaston, O. Calnevaro, C. Gallego et al., "Platypneaorthodeoxia syndrome, atrial septal aneurysm and right hemidiaphragmatic elevation with a right-to-left shunt through a patent foramen ovale," Medicina, vol. 65, no. 3, pp. 252-254, 2005 (Spanish).

[6] R. Maholic and D. Lasorda, "Successful percutaneous closure of a patent foramen ovale causing hypoxia in the setting of an elevated hemidiaphragm due to guillian-barre syndrome," The Journal of Invasive Cardiology, vol. 18, no. 9, pp. 434-435, 2006.

[7] L. A. Perkins, S. M. Costa, C. D. Boethel, and M. E. Lawrence, "Hypoxemia secondary to right-to-left interatrial shunt through a patent foramen ovale in a patient with an elevated right hemidiaphragm," Respiratory Care, vol. 53, no. 4, pp. 462-465, 2009.

[8] T Fabris, P. Buja, U. Cucchini et al., "Right-to-left interatrial shunt secondary to right hemidiaphragmatic paralysis: An unusual scenario for urgent percutaneous closure of patent foramen ovale," Heart, Lung and Circulation, vol. 24, no. 4, pp. e56-e59, 2015.

[9] K. Sakagianni, D. Evrenoglou, D. Mytas, and M. Vavuranakis, "Platypnea-orthodeoxia syndrome related to right hemidiaphragmatic elevation and a stretched patent foramen ovale," BMJ Case Rep, vol. 2012, Article ID 007735, 2012.

[10] J. S. Darchis, P. V. Ennezat, C. Charbonnel et al., "Hemidiaphragmatic paralysis: An underestimated etiology of rightto-left shunt through patent foramen ovale?" European Heart Journal--Cardiovascular Imaging, vol. 8, no. 4, pp. 259-264, 2007.

[11] P. T. Hagen, D. G. Scholz, and W. D. Edwards, "Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts," Mayo Clinic Proceedings, vol. 59, no. 1, pp. 17-20, 1984.

[12] D. C. Fisher, E. A. Fisher, J. H. Budd, S. E. Rosen, and M. E. Goldman, "The incidence of patent foramen ovale in 1,000 consecutive patients: a contrast transesophageal echocardiography study" CHEST, vol. 107, no. 6, pp. 1504-1509, 1995.

[13] M. Zanchetta, G. Rigatelli, and S. Y. Ho, "A mystery featuring right-to-left shunting despite normal intracardiac pressure" CHEST, vol. 128, no. 2, pp. 998-1002, 2005.

[14] M. El Tahlawi, B. Jop, B. Bonello et al., "Should we close hypoxaemic patent foramen ovale and interatrial shunts on a systematic basis?" Archives of Cardiovascular Diseases, vol. 102, no. 11, pp. 755-759, 2009.

Hussain Ibrahim, Adnan Khan, Shawn P. Nishi, Ken Fujise, and Syed Gilani

University of Texas Medical Branch, 301 University Boulevard, 5.106 John Sealy Annex, Galveston, TX 77555-0553, USA

Correspondence should be addressed to Hussain Ibrahim; huibrahi@utmb.edu

Received 23 June 2017; Accepted 19 September 2017; Published 16 October 2017

Academic Editor: Samer Al-Saad

Caption: Figure 1: Chest X-ray with right hemidiaphragm paralysis.

Caption: Figure 2: Transesophageal echocardiogram with Doppler demonstrating right-to-left interatrial shunting through the patent foramen ovale.
Table 1: Literature review:

Patient #     Author, year       Age and       SOB
                                  gender     duration

(1)          Murray et al.,      72, male    3 months
                1991 [2]

(2)            Cordero et        57, male     1 month
              al., 1994 [3]

(3)         Ghamande et al.,    79, female    6 weeks
                2001 [4]

(4)         Lopez Gaston et      75, male     7 days
              al., 2005 [5]

(5)           Maholic and       84, female    1 month
            Lasorda, 2006 [6]

(6)         Perkins et al.,     73, female    2 weeks
                2008 [7]

(7)          Fabris et al.,     66, female   Few weeks
                2015 [8]

(8)          Sakagianni et      72, female    3 weeks
              al., 2012 [9]

(9)         Darchis et al.,     79, female    3 weeks
                2007 [10]

(10)        Darchis et al.,     61, female     Acute
                2007 [10]

(11         Darchis et al.,     84, female    3 weeks
                2007 [10]

Patient #    Hemidiaphragm        Probable cause          Side of
               diagnosis            of paralysis        hemidiaphragm

(1)         CXR, fluoroscopy      Idiopathic/Viral          Right

              Chest X-ray,
(2)         sniff test, EMC         Neurapraxia             Right

(3)          CT, sniff test         Postsurgical            Right

(4)         CXR, chest CT,        L central line            Right
              fluoroscopy            placement

(5)          Chest X-ray,          Guillain Barre           Right
               sniff test

(6)          Chest X-ray,            Idiopathic             Right
               Sniff Test

(7)           Chest X-ray            Idiopathic             Right

(8)           Chest X-ray          After surgery            Right

(9)           Chest X-ray         Liver mets and            Right
                                   enlarged liver

(10)          Chest X-ray          Postsurgical             Right
                               (phrenic nerve injury)

(11           Chest X-ray            Idiopathic             Right

                                                      Pa[O.sub.2]
                                                       correction
Patient #     RAP      PA Pressure    PFO closure     on arterial
            (M/A/V)    (M/A/V) mmHg    improving      blood gases
              mmHg                      hypoxia      on PFO closure

(1)          Normal         --            Yes            60 to
                                                        71 mmHg

                                                         37 to
(2)                                    Not closed       78 mmHg

(3)          7/9/7       30/15/21         Yes           55 mmHg
                                                        before
                                                        closure

(4)            2           19.4           Yes            50 to
                                                        63 mmHg

(5)         5, mean        22/5           Yes            48 to
                                                        67 mmHg

(6)         5, mean      14 mean          Yes           65 mmHg
                                                        before
                                                        closure

(7)            3         12 mean          Yes              --

(8)            14        36/19/24         Yes           Patient
                                                      on vent at
                                                        time of
                                                        closure

(9)            4            --            Yes            60 to
                                                        78 mmHg

(10)           5            --            Yes            61 to
                                                        84 mmHg

(11            --           --            Yes            49 to
                                                        74 mmHg
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Title Annotation:Case Report
Author:Ibrahim, Hussain; Khan, Adnan; Nishi, Shawn P.; Fujise, Ken; Gilani, Syed
Publication:Case Reports in Pulmonology
Date:Jan 1, 2017
Words:1989
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