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Swedish study finds potential proteomic biomarkers for Alzheimer's in cerebrospinal fluid.

Swedish study finds potential proteomic biomarkers for Alzheimer's in cerebrospinal fluid. A mass spectrometry-based analysis of cerebrospinal fluid in Alzheimer's disease (AD) patients has yielded a handful of potential biomarkers for the disease.

The researchers used label-free shotgun mass spectrometry to look at proteins in the cerebrospinal fluid of 10 AD patients and 10 healthy controls. They also performed protein depletion of high-abundance proteins to improve detection and quantification of low-abundance proteins.

The authors found eight proteins that were differentially expressed between the two study groups. "ApoM, LRG, FBLN3, and PTPRZ have functions related to cell adhesion, migration, and morphology," and may also be associated with other aging-associated diseases like cancer and diabetes, they wrote. C1QB, C1QC, complement C1S, and SEZ6 may be implicated in synapse development.

"Cerebrospinal fluid is a proximal fluid in direct contact with the brain interstitial fluid that potentially reflects biochemical changes related to [the] central nervous system, making it a promising source of biomarkers in neurological disorders such as AD," they added. While Alzheimer's disease is associated with several proteomic markers, especially the protein tau and beta-amyloid peptides, those have limited value for monitoring disease progression.

In their paper, the authors also pointed out other factors that might have influenced results. In addition to the small study size, they noted that there was a slight age difference between the two groups, where the controls were, on average, nine years older than participants in the Alzheimer's group; protein levels in cerebrospinal fluid are thought to change with age. The lower protein levels could also be the effect of protein depletion.

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Title Annotation:Alzheimer's Disease
Publication:Medical Laboratory Observer
Article Type:Brief article
Geographic Code:1USA
Date:Apr 1, 2016
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