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Supplements accelerate benzodiazepine withdrawal: a case report and biochemical rationale.

A middle-aged male had success rapidly reducing fast-acting alprazolam (Xanax) dosage by taking very high doses of niacin, along with gamma-aminobutyric acid (GABA) and vitamin C. The individual had been on 1 mg/day Xanax for 2 years, a moderate dose but a long duration. As a result, he had been presenting increased anxiety, personality changes, and ringing in the ears (tinnitus), all side effects likely due to long-term alprazolam use. Typical withdrawal from this drug would involve substitution medication and about a 10% dose reduction per week, and take a matter of months. (1) A fast withdrawal is a 12.5 to 25% reduction per week. (2) On very high doses of niacin, vitamin C, and also GABA, this individual reported being able to cut the dose 60% down to 0.4 mg in one week. The dose was reduced by 90% (to 0.1 mg/ day) in less than a month. He reported residual anxiety, but that it was substantially less than when fully medicated. After 5 weeks, the medication intake was zero, with minimal residual anxiety.

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Author:Penberthy, W. Todd; Saul, Andrew W.
Publication:Townsend Letter
Article Type:Brief article
Date:Oct 1, 2016
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