Printer Friendly

Subcutaneous Lobular Capillary Hemangioma Presenting as a Facial Mass.

1. Introduction

Lobular capillary hemangioma (LCH), characterized by benign proliferation of capillaries with a lobular architecture, is a common benign vascular tumor of children and adults [1]. The International Society for the Study of Vascular Anomalies includes LCH in the benign vascular tumor group [1]. LCH may occur at all ages; however, LCH is more frequently seen in women and men under 18 years of age [2]. The most common etiologic factors are trauma, hormonal factors, and poor oral hygiene.

The majority of LCH present on the head and neck, commonly involving gingiva, lips, tongue, and buccal mucosa. LCH is rarely located in the nasal cavity [3]. The anterior septal mucosa, tip of the turbinate, and the vestibule are the common nasal cavity sites for LCH [4]. LCH may involve superficial cutaneous, mucosal, and subcutaneous structures. The rare occurrence and deep location of subcutaneous variant makes the clinical diagnosis challenging. We conducted a retrospective chart review to report the clinical, radiologic, and histological features of LCH in a child with a subcutaneous lateral nasal mass.

2. Case Report

A 12-year-old male with past medical history of type II diabetes mellitus presented with a gradually enlarging mass on the left lateral nasal wall for 8 months (Figure 1). The patient hit his nose on his brother's head a year ago. The child had no nasal obstruction, no epistaxis, no recurrent sinus infections, no anosmia nor hyposmia, and no snoring. There was no family history of childhood cancers. On physical examination, the 1.5 x 1.5 cm mass was a firm, nontender, immobile, subcutaneous mass in the region of the frontal process of the maxilla. There was no color change of the overlying skin. The patient presented to clinic with a magnetic resonance imaging (MRI) that did not show the mass due to artifact. Limited MR imaging suggested possible nasal dermoid. Computerized tomography of the mass documented a hyperdense and nonlipomatous mass involving soft tissue of the left lateral nasal wall (Figure 2). An excisional biopsy was performed. There was no apparent intranasal extension. Upon resection, histologic evaluation showed subcutaneous lobular capillary hemangioma (Figure 3). At 3 month follow-up, the surgical site was healed with no evidence of recurrent lesion.

3. Discussion

In the present study, subcutaneous LCH was documented in a child with a history of trauma to the nose. While no direct causal relationship has been identified, there is an association with estrogen exposure and trauma. Five percent of pregnant patients experience a new onset LCH, especially of the gingiva, hence the term "pregnancy tumor" [5]. Exogenous hormone therapy has also been implicated as a risk factor. Additionally, receptors to the beta isoform of estrogen have been identified on various vascular tumors, including hemangiomas, possibly supporting a hormonal etiology [6]. Prior local trauma is also frequently reported in the patient history, as was in this case; however, it is not considered necessary for development [5].

Histologically, LCH consists of a benign proliferation of capillaries arranged in lobules separated by fibrous septa [7]. Superficial lesions may ulcerate and be associated with inflammation and edema, while the deeper lesions often lack inflammation. The historical terminology, pyogenic granuloma, is a misnomer as the mass is neither infectious or pus producing nor granulomatous. Therefore, the current terminology of LCH is recommended. While usually not needed, immunohistochemistry for endothelial markers CD31 and Factor VIIII may be helpful.

The variants of LCH include oral mucosal, satellite, intravenous, dermal, and subcutaneous. Subcutaneous, as described in this case, is the rarest form of LCH and lacks the distinct friable, raised, easily bleeding appearance that is characteristic of the more common counterpart. A review of 106 LCH cases at a single institution found an incidence of 3.4% for the subcutaneous variant [5]. The clinical differential diagnosis of subcutaneous LCH includes a wide variety of subcutaneous pathologies, including but not limited to vascular malformation, Kaposiform hemangioendothelioma, and infantile hemangioma. The present case must also take into account the differential diagnosis for a child with a nasal sidewall mass. The clinical differential diagnosis of lateral nasal wall mass includes nasal dermoid, encephalocele, neoplasm, vascular malformation, and other various reported entities such as foreign body inclusion cyst and heterotopic glial tissue [8, 9]. Surgical treatment with complete excision is the mainstay of treatment and also provides definitive diagnosis. Recurrence, occurring in 16%, is due to incomplete excision of the mass [4, 10]. No malignant change has been reported [4].

In conclusion, subcutaneous mass can manifest as a lateral nasal wall mass in children, and excision of the mass forms the mainstay of treatment. Prompt diagnosis and treatment of subcutaneous LCH is essential to prevent complication or sequela.


An earlier version of this manuscript was presented in part at the Annual Meeting of American Society of Pediatric Otolaryngology, April 20-22, 2018, in National Harbor, Maryland, USA.

Conflicts of Interest

The authors declare that they have no conflicts of interest.


[1] M. Wassef, F. Blei, D. Adams et al., "Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies," Pediatrics, vol. 136, no. 1, pp. e203-e214, 2015.

[2] N. Lee, A. Isenstein, D. Zedek, and D. Morrell, "A case of childhood subcutaneous pyogenic granuloma (lobular capillary hemangioma)," Clinical Pediatrics, vol. 51, no. 1, pp. 88-90, 2012.

[3] S. N. Ifeacho and H. M. Caulfield, "A rare cause of paediatric epistaxis: lobular capillary haemangioma of the nasal cavity," BMJ Case Reports, vol. 2011, p. bcr0720103199, 2011.

[4] F. R. Miller, M. A. D'Agostino, and K. Schlack, "Lobular capillary hemangioma of the nasal cavity," Otolaryngology-Head and Neck Surgery, vol. 120, no. 5, pp. 783-784, 1999.

[5] S. J. Patrice, K. Wiss, and J. B. Mulliken, "Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases," Pediatric Dermatology, vol. 8, no. 4, pp. 267-276, 1991.

[6] A. T. Deyrup, M. Tretiakova, A. Khramtsov, and A. G. Montag, "Estrogen receptor beta expression in vascular neoplasia: an analysis of 53 benign and malignant cases," Modern Pathology, vol. 17, no. 11, pp. 1372-1377, 2004.

[7] R. R. Fortna and J. M. Junkins-Hopkins, "A case of lobular capillary hemangioma (pyogenic granuloma), localized to the subcutaneous tissue, and a review of the literature," American Journal of Dermatopathology, vol. 29, no. 4, pp. 408-411, 2007.

[8] S. O. Ulualp, K. Koral, and S. Cope-Yokoyama, "An unusual lateral nasal wall mass: heterotopic glial tissue," International Journal of Pediatric Otorhinolaryngology Extra, vol. 6, no. 4, pp. 416-418, 2011.

[9] B. A. Bassichis and J. Thomas, "Foreign-body inclusion cyst presenting on the lateral nasal sidewall 1 year after rhinoplasty," Archives of Facial Plastic Surgery, vol. 5, no. 6, pp. 530-532, 2003.

[10] H. Jafarzadeh, M. Sanatkhani, and N. Mohtasham, "Oral pyogenic granuloma: a review," Journal of Oral Science, vol. 48, no. 4, pp. 167-175, 2006.

Charles Saadeh, (1) Seckin O. Ulualp [ID], (1,2) and Dinesh Rakheja (3)

(1) Department of Otolaryngology, Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA

(2) Division of Pediatric Otolaryngology, Children's Health, Dallas, TX, USA

(3) Division of Pathology, Children's Health, Dallas, TX, USA

Correspondence should be addressed to Seckin O. Ulualp;

Received 10 January 2018; Accepted 5 April 2018; Published 8 May 2018

Academic Editor: Harukazu Hiraumi

Caption: FIGURE 1: Subcutaneous mass with no color change of the overlying skin in the region of the frontal process of the maxilla.

Caption: FIGURE 2: Axial contrast-enhanced CT images showing a well-demarcated, hyperdense, and nonlipomatous mass involving soft tissue of the left lateral nasal wall.

Caption: FIGURE 3: Photomicrograph of the excised specimen showing a proliferation of capillaries arranged in lobules separated by fibrous septa (hematoxylin and eosin, 40x original magnification).
COPYRIGHT 2018 Hindawi Limited
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2018 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:Case Report
Author:Saadeh, Charles; Ulualp, Seckin O.; Rakheja, Dinesh
Publication:Case Reports in Otolaryngology
Date:Jan 1, 2018
Previous Article:A Very Rare Case of Hypereosinophilic Syndrome Secondary to Natural Killer/T-Cell Lymphoma.
Next Article:Gradenigo's Syndrome and Labyrinthitis: Conservative versus Surgical Treatment.

Terms of use | Privacy policy | Copyright © 2021 Farlex, Inc. | Feedback | For webmasters |