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Study finds antiepileptic drugs increase risk of Alzheimer's and dementia.

M2 EQUITYBITES-April 9, 2018-Study finds antiepileptic drugs increase risk of Alzheimer's and dementia


A new study from the University of Eastern Finland and the German Centre for Neurodegenerative Diseases (DZNE), suggests that there is an association between the use of antiepileptic drugs and an increased risk of Alzheimer's disease and dementia, Manufacturing Chemist reported on Monday.

In the Finnish dataset, continuous use of antiepileptic drugs for a period exceeding one year was associated with a 15% increased risk of Alzheimer's disease, while the German dataset found there was a 30% increased risk of dementia.

Certain antiepileptic drugs are known to impair cognitive function and, when comparing different antiepileptic drugs, the researchers found the risk was specifically associated with drugs that impair cognitive function. These drugs were associated with a 20% higher risk of Alzheimer's disease and a 60% increased risk of dementia.

There was also a correlation between a higher dose of a drug that impairs cognitive function and a higher risk of dementia. However, the researchers noted that there were no associated risks with other antiepileptic drugs that do not impair cognitive processing.

The results have been published in the Journal of American Geriatrics Society. It was the largest research on this topic so far and the first to investigate an association between regularity of use and dose and to conduct a comparison between antiepileptic drugs with and without cognitive-impairing effects.

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Publication:M2 EquityBites (EQB)
Date:Apr 9, 2018
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