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Study details new molecular approach to preventing Alzheimer's.

Study details new molecular approach to preventing Alzheimer's.

The April 24 Washington Post reported that German researchers have developed a new approach to the possible prevention of the molecular "debris" that is associated with the development of Alzheimer's disease. The basic idea--to block the activity of an enzyme called beta secretase--is not original, says a new study's lead author. Both academic and commercial laboratories are working on methods to prevent the enzyme from slicing a protein into beta-amyloid fragments that form the brain plaques found in victims of the disease. Most experts now agree that formation of the beta-amyloid plaques is directly linked to the development of Alzheimer's. The problem with most proposed methods of blocking beta secretase, the study found, is that they are designed to work outside of the affected brain cells. The researchers point out that the process of cleaving takes place inside cells, so they have constructed an inhibitor, which binds outside, on the cell membrane, and goes into the cell where the cleavage occurs.
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Title Annotation:New studies
Publication:Medical Laboratory Observer
Article Type:Brief article
Geographic Code:4EUGE
Date:Jun 1, 2008
Words:169
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