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Structure and ultrastructure of parotid salivary glands of autoimmune diabetic mice submitted to long-term insulinic treatment.

STRUCTURE AND ULTRASTRUCTURE OF PAROTID SALIVARY GLANDS OF AUTOIMMUNE DIABETIC MICE SUBMITTED TO LONG-TERM INSULINIC TREATMENT. Eduardo Jose Caldeira, Jose Angelo Camilli, Valeria Helena Alves Cagnon. Department of Anatomy, Institute of Biology, UNICAMP, Brazil. e-mail:

The Diabetes mellitus and the effects in the salivary glands have been studied as much experimentally as in the clinically. Despite of the knowledge of the several functional complications of this gland in the diabetic person, doubts persist as to the cellular behavior and of the effects of the insulinic treatment. Therefore, the objective of the present study was characterize the therapeutic effects of the long term insulinic treatment in the structure and ultrastructure of the cells of the parotid glands in the autoimmune diabetic mice. A total of 27 females mice were divided in 3 groups: 9 Nod diabetic during 20 days (I), 9 Nod diabetic during 20 days (II) and 9 not diabetic BALB/C (III). After the period of effective diabetic state the animals of the group I received subcutaneous insulin during 20 days, while the mice of the groups II and III received physiological solution simulating the experimental conditions. Samples of the parotid glands were analyzed for light and transmission electronics microscopies. The results revealed alterations in the diabetic animal without insulinic treatment characterized by the nuclear atrophy and cytoplasmatic disorganization of the biomembranes and increase of the fibrillar components of extracelular matrix.In the animals submitted to the long term insulinic treatment showed structural recuperation, however maintaining harmful effects. So, it was concluded that the diabetic animal and in the animal submitted to the long-term insulinic treatment occurred harmful effects, wich can get compromise the maintenance and cellular renewal, and can alter the functional mechanisms, showing that the insulinic treatment did not recuperate the morphology neither did the cellular function.

Support: FAPESP (03/1377-3)

Key Words: Salivary Glands, diabetes mellitus and Insulin

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Author:Caldeira, Eduardo Jose; Camilli, Jose Angelo; Cagnon, Valeria Helena Alves
Publication:International Journal of Morphology
Date:Mar 1, 2007
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