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Structure, function, and modulation of neuronal voltage-gated ion channels.


Structure, function, and modulation of neuronal voltage-gated ion channels.

Gribkoff, Valentin K. and Leonard K. Kaczmarek.

John Wiley & Sons


475 pages




Scientists in neurology, anesthesiology, and other medical and biological disciplines explore the channels from a number of perspectives, including drug discovery and development. They do not aspire to provide comprehensive coverage, but to inspire students by demonstrating how the research is conducted and what kind of findings may result. Among the topics are multiple roles of voltage-gated sodium channels in the pathophysiology of pain, roles of unique mitochondrial ion channels in synaptic transmission and programmed cell death, the effect of hypoxia-ischemia on voltage-dependent channels, the regulation of neuronal ion channels by G-protein-coupled receptors in sympathetic neurons, neuronal Kv7 potassium channels as emerging targets for treating pain, and high-throughput screening technologies in ion channel drug discovery.

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Publication:SciTech Book News
Article Type:Brief article
Date:Jun 1, 2009
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