Printer Friendly

Stem cell niche nourishment.

The normal functioning of stem cells requires a nourished environment within the tissue--the stem cell niche--as an indispensable element. The extracellular matrix (ECM) and the growth-regulating proteins within the ECM as well as microbiome-made synbiotic proteins contribute to this niche. Restoring inner ecosystem biodiversity and sustainability allows the rich genetic diversity of the microbiome to make a goldmine of synbiotic nutrients that empower cellular reprogramming. Stimulus-triggered acquisition of pluripotency (STAP) without the need for nuclear transfer or the introduction of transcription factors has recently been demonstrated by scientists. (1)

Observing the infallible wisdom in nature, scientists observed how plant cells can become pluripotent stem cells when nutrient levels or other environmental factors are altered. (2) And Shinya Yamanaka of Kyoto University, who won the Nobel prize in Physiology or Medicine in 2012, demonstrated that it is possible to force the over-expression of proteins called transcription factors in differentiated cells to turn back the clock and make cells behave like embryonic stem cells. (3)

These findings have the potential to sidestep the ethical objections to the use of embryos and the limitations of other methodologies. Nourishment offers cheaper, quicker, and potentially better ways to augment stem cell regeneration.

In nature, somatic cells latently possess a dynamic plasticity--the ability to become pluripotent cells--when they are exposed to stimuli or polarized nutrient formats not normally in their environment. In other words, these findings raise the possibility that proteins in quantum formats act as regulatory modules and may be the key that unlocks static or toxic epigenetic states, leading to a global change in epigenetic regulation toward stem cell regeneration.

As I have explained in my earlier publications, the bioclock activity of genes are "switched on and off by proteins that are assembled in molecular sequences via quantic events." (4) In the past, I have provided a model for nourishing the niches of stem cells via efferent-afferent and microbiome modification. (6-8) It is well known that ECM nourishment can sequester and modulate stem cell niches along with synbiotic protein peptide formats to modulate stem cell niches and that afferent neurons can accomplish some astounding feats of regeneration and neurogenesis. (5,9-12) A default in ECM modulation occurs when microbial cells functioning as nutrient factories are depleted or when afferents neurons are desensitized by nonpolar lipids, denatured proteins, and the ionic stressors that are common in most water purification methods. (6,13,14) In order to activate deeper capacities for healing via the stem cell niche, we have to focus on cell polarity and its effect on microflora composition, loops, and processes such as intestinal adherence and translocation.

Synbiotic nourishment research by Bengmark supports my earlier synbiotic nutrient research on the importance of biomolecular nutrient and cell polarity formats that are critical to adequately nourish stem cell niches, the gut habitat, and afferent regenerative functions. (8,18-20) A huge part of restoring the stem cell niche has to do with restoring the active phase of motility or oscillatory motion in the direction of the original embryonic migration. In this regard, polarized sulfolipids are indispensable, as they calibrate microflora, empower the liver's sulfation pathway to erase gut inflammation, and transform the gut lumen into a habitat that favors persistent commensalism and symbiosis. (21-27) It took me over four decades of empirical research to understand how to recolonize the gut and restore the gut habitat in patients with a past history of taking antibiotics or natural anti-infective remedies. Ideally, clinicians need to stop obsessing on killing microbes and start restoring the gut ecosystem status that nourishes the stem cell niche. (6,8,15,18)

Nature integrates all ecosystem cycles and is the final arbiter of truth and unquestionable authority on cell polarity, stem cell niches, and the gut ecosystem cycle determinants that can help us reach a superorganism potential. When in doubt about a medical practice or dietary supplement, do we constantly cross-check what we know against the way things are found in nature so that we may gain the kind of empirical wisdom that truly benefits our sick patients?

In summary, stem cells can turn into many different types of cells, and research demonstrates that they have a niche. (11,12,28) The ultimate way to control their differentiation is to control and nourish their niche. (28) In turn, these niches keep the stem cells fed and nourished similar to the way that queen bees make drones.

by Dr. Paul Yanick

President of the American Academy of Quantum Medicine

www.aaqm.org

Notes

(1.) Obukato H et al. Stimulus-triggered fat conversion of somatic cells into pluripotency. Nature. 2014;505:641-647.

(2.) Thorpe TA. History of plant tissue culture. Mol Biotechnol. 2007;37:169-180.

(3.) Yamanaka S et al. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006:126;663-676.

(4.) Yanick P. New insights into brain fog, memory & learning disorders, insomnia, anxiety, depression & immune disorders. Townsend Lett. June 2000:154-156.

(5.) Philips RJ et al. Long-term regeneration of abdominal vagus: Efferents fail while afferents succeed. J Comp Neurol. 2003;455:222-237.

(6.) Yanick P. Extracellular matrix bioregulation and stem cell regeneration. Townsend Lett. 2011;91-92.

(7.) Yanick P. Activating quantum healing with new flexoelectric technologies. Townsend Lett. 2003; 154-156.

(8.) Yanick P. Efferent-afferent and microbiota imbalances in MCS and fibromyalgia. Townsend Lett. November 2009:99-101.

(9.) Daly WP et al. ECM dynamics in development and regenerative medicine. J Cell Sci. 2008;121:255-264.

(10.) Badylak SF et al. Progress in tissue engineering and regenerative medicine. Proc Natl Acad Sci USA. 2010:107;3286-3286.

(11.) Haylock DN et al. Stem cell regulation by the hematopoietic stem cell niche. Cell Cycle. 2005;4:1353-1355.

(12.) Moore KA et al. Stem cells and their niches. Science. 2006;311:1880-1883.

(13.) Yanick P. Colonization resistance of barrier microflora in carcinogenesis and allergic patients. Townsend Lett. August/Sept 2010:98-100.

(14.) Wand L et al. The maintenance and generation of membrane polarity in hepatocytes. Hepatology. 2004;39(4):892-899.

(15.) Yanick P. The forgotten role of water in achieving a superorganism potential. Townsend Lett. July 2013.

(16.) Yanick P. Detoxification secrets and healing power of water. Townsend Lett. November 2005.

(17.) Yanick P. Activating quantum healing with new flexoelectric technologies. Townsend Lett. 2003; 154-156.

(18.) Bengmark S. Nutrition of the critically ill--emphasis on liver and pancreas. Hepatobiliary SurgNutr. 2012;1(1):25-52.

(19.) Yanick P. Bimolecular nutrition and the GI system. Townsend Lett. December 1993; 1248-1253.

(20.) Yanick P. Gastrointestinal rejuvenation via synbiotic nourishment to upregulate prebiotic butyrate, IGFs and HGH. Townsend Lett. June 2006;109-111.

(21.) Wand L et al. The maintenance and generation of membrane polarity in hepatocytes. Hepatology. 2004;39(4):892-899.

(22.) Arias IM et al. Regulation of bile canalicular network formation & maintenance by AMPP-activated protein kinease LKB1. J Cell Sci. 2010;123:3294-3302.

(23.) Arias IM et al. Bile acid stimulates hepatocyte polarization. Proc Natl Acad Sci USA. 2011;108:1403-1408.

(24.) Arias IM et al. The biology of the bile canaliculus, 1993. Hepatology. 17:318-329.

(25.) Bryant DM et al. From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol. 2008;9:887-901.

(26.) Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol. 2007;8:774-785.

(27.) Jansen M et al. LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol Rev. 2009;89:777-798.

(28.) Morrison SJ et al. Stem cells and niches. Cell. 2008;132:598-611.

Dr. Paul Yanick is board-certified diplomat in integrative medicine, anti-aging medicine, and quantum medicine. He is the founder and president of the nonprofit American Academy of Quantum Medicine in charge of national board certification in quantum medicine. Earlier in his career, his hospital and university research was the first to link neurological and ear disorders to cell polarity and nutritional deficits (Journal of the American Audiology Society, 1975:2; Journal of Applied Nutrition, 1988:40; Journal of Medical Audiology 1983:5; International Journal of Holistic Health and Medicine 1893:1). These breakthrough discoveries saved his life from two incurable and terminal illnesses.
COPYRIGHT 2014 The Townsend Letter Group
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2014 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Author:Yanick, Paul
Publication:Townsend Letter
Article Type:Report
Geographic Code:1USA
Date:Jun 1, 2014
Words:1347
Previous Article:Vascular biology, endothelial function, and natural rehabilitation: part 2: oxidative and nitrosative stress.
Next Article:Do we all suffer from omega-6 fatty acid deficiency?
Topics:

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters