Printer Friendly

Staphylococcal scalded skin syndrome in an adult, immunocompetent patient.

Dear Editor,

An 87-year old female patient, with history of chronic obstructive pulmonary disease, was referred to our hospital with rash and septic shock. She was obese (body mass index 46kg/[m.sup.2]) and had a recent history of left shin cellulitis, for which she had received clindamycin. The patient's main clinical findings on presentation were hypotension, tachypnea, anuria and severe exfoliation of the skin affecting the entire body (Fig. 1). Nikolsky sign was elicited on patient's physical examination (Fig. 2). The diagnosis of Staphylococcal scalded skin syndrome (SSSS) was clinically established and empiric therapy with vancomycin was started as well as supportive care with fluids and oxygen. The patient died 24 h after admission, after having developed multiple organ dysfunction syndrome.

SSSS, also known as Pemphigus neonatorum or Ritter's disease, is caused by exotoxins released by Staphylococcus aureus, which act as proteases breaking down desmosomes. (1) This results in the separation of the epidermis beneath the granular cell layer and the appearance of the disease's characteristic red rash. The condition is commonest in children and infants, where prognosis is considered to be favorable if appropriate therapy is given. On the other hand, SSSS is rare in adults, but the mortality rate is significantly higher (greater than 60%). (2) It is mainly observed among immunosuppressed individuals or subjects with severe chronic diseases. Laboratory or imaging studies are of limited diagnostic use of the syndrome. Nevertheless, S. aureus can be isolated from blood cultures. Nikolsky sign, named after Russian physician Pyotr Nikolsky who first described it in 1896, is present when the top layer of the skin slips off with rubbing or on gentle pressure. (3) The sign is elicited in patients with SSSS, as well as in other conditions, with toxic epidermal necrolysis being the most identifiable. Treatment options in SSSS include supportive measures, such as fluids and antipyretic drugs. However, the key point is the control of the underlying staphylococcal infection with appropriate antibiotic therapy. Intensive care unit support is often a necessity for patients with SSSS.

In conclusion, despite being uncommon in adults, SSSS represents a therapeutic challenge for any physician, because of its significantly higher mortality rate.

Conflicts of interest

The authors declare no conflicts of interest.

REFERENCES

(1.) Hayakawa YHashimoto N, Imaizumi K, Kaidoh T, Takeuchi S. Genetic analysis of exfoliative toxin A-producing Staphylococcus aureus isolated from mastitic cow's milk. Vet Microbiol. 2001;78:39-48.

(2.) Patel GK, Finlay AY. Staphylococcal scalded skin syndrome: diagnosis and management. Am J Clin Dermatol. 2003;4:165-75.

(3.) van Gijn J, Gijselhart JP. Nikolsky and his sign. Ned Tijdschr Geneeskd. 2011;155:A2846.

Theocharis Koufakis *, Ioannis Gabranis, Konstantinos Karanikas

Department of Internal Medicine, General Hospital of Larissa, Larissa, Greece

* Corresponding author at: 49 Ioustinianou Street, P.C. 41223 Larissa, Greece.

E-mail address: thkoyfak@hotmail.com (T. Koufakis).

Received 6 December 2014

Accepted 10 December 2014

Available online 18 February 2015

http://dx.doi.org/10.1016/j.bjid.2014.12.011

COPYRIGHT 2015 Contexto
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2015 Gale, Cengage Learning. All rights reserved.

 
Article Details
Printer friendly Cite/link Email Feedback
Author:Koufakis, Theocharis; Gabranis, Ioannis; Karanikas, Konstantinos
Publication:The Brazilian Journal of Infectious Diseases
Article Type:Letter to the editor
Date:Mar 1, 2015
Words:493
Previous Article:Treatment of genotype one hepatitis C virus (HCV) infection in HIV co-infected patients using telaprevir based regimen.
Next Article:Raoultella ornithinolytica causing fatal sepsis.

Terms of use | Privacy policy | Copyright © 2018 Farlex, Inc. | Feedback | For webmasters