Staph receptor as drug target.
When researchers injected doses of S. aureus under the skin of mice, the animals developed toxin-induced abscesses at those sites within 2 days. But when mice were concurrently given the bacteria and a dose of a peptide that binds to and shuts down AgrC, toxin production was limited. That bought enough time for the animals' immune systems to dispatch white blood cells that killed the bacteria and prevented abscesses, says Noviek.
The inhibitory effect on the receptor lasts up to 2 days. Oddly, the peptide doesn't last that long in the body. That transience probably dooms the peptide's prospects as a drug, Noviek says. But researchers are already investigating other compounds that might bind to and disable the S. aureus AgrC receptor, he says.--N.S.
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|Title Annotation:||Infectious Disease|
|Article Type:||Brief Article|
|Date:||Nov 20, 2004|
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