Spinal cord involvement of multiple myeloma detected by F-18 FDG PET/CT scan / F-18 FDG PET/CT tarama ile saptanan multiple myeloma'nin spinal kord tutulumu.
Quad % Gated X Mean Y Mean UL 3.11 10.39 1194.91 UR 19.46 144.44 166.16 LL 24.90 3.53 7.18 LR 52.53 281.98 3.06 Figure 1. Three plane PET images (CT, PET and fused PET/CT in axial, sagittal and coronal projections) shows an intense F-18 FDG uptake with a maximum standard uptake value (SUVmax) of 5.7 in the thoracic 9th, 10th and 11th vertebrae and FDG avid masses in sternum and left 9th rib Note: Table made from bar graph.
[FIGURE 2 OMITTED]
Extramedullary spread of MM may occur either at diagnosis or during the course of the disease. The involvement of central nervous system (CNS) occurs in approximately] % of patients (1-3) and may present either with localized cerebral lesions or with meningeal myelomatosis, defined by the presence of monoclonal plasma cells in the CSF. The clinical presentation of CNS involvement include a wide set of neurological signs and symptoms, but headache, confusion, and limb weakness are the most common (3-5). However, even in patients without circulating plasma cells, the haematogenous spread of their lymphoid progenitors has been postulated as a possible mechanism for CNS involvement (6).
Active myeloma is FDG-positive for focal and diffuse abnormalities. It has been reported that FDG PET can significantly contribute to an accurate whole-body evaluation of multiple myeloma patients due to the ability to visualise highly energyconsuming cells such as tumour cells (7), (8). In addition, the limited anatomical resolution of PET can be overcome by co-registration of functional PET images with morphological CT data with an integrated PET/CT system.
Written informed consent was obtained from the patient.
Conflict of Interest
No author of this paper has a conflict of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included in this manuscript.
Address for Correspondence: M.D. Ilknur Ak Sivrikoz, Department of Nuclear Medicine, Eskisehir Osmangazi University, School of Medicine, Eskisehir, Turkey Phone: +90 222 239 29 79 E-mail: email@example.com
RELATED ARTICLE: Obituary
Prof. Huseyin Sipahioglu (1925-2010)
A Turkish hematologist, Professor Huseyin Sipahioglu, passed away September 11, 2010. He made several contributions to Turkish hematology including filiariasis, thalassemia, G6PD deficiency. In 1947, he graduated from Istanbul University Faculty of Medicine and had his Internal Medicine residency at Vakif Gureba. He worked at Istanbul University and Kayseri Gevher Nesibe University Medical School, respectively. He was the dean of Gevher Nesibe Medical School between 1978-1980 and then he was the rector of Kayseri Erciyes University between 1980-1982. He retired in 1982. Sipahioglu had over 200 published articles (14 international) and 5 printed books including his memories.
Nejat Akar, MD, Prof.
Ankara University, Turkey
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(4.) Petersen S, Wagner A, Gimsing P: Cerebral and meningeal multiple myeloma after autologous stem cell transplantation: A case report and review of the literature. Am J Hematol. 1999;62:228-33.
(5.) Patriarca F, Zaja F, Silvestri F, Sperotto A, Scalise A, Gigli G, Fanin R. Meningeal and cerebral involvement in multiple myeloma patients. Ann Hematol. 2001;80:758-62
(6.) Warner TF, Krueger RG: Circulating lymphocytes and the spread of myeloma: Review of the evidence. Lancet 3;1:1174-6.
(7.) Ltitje S, de Rooy JW, Croockewit S, Koedam E, Oyen WJ, Raymakers RA. Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myeloma. Ann Hematol. 2009;88:1161-8.
(8.) Ilknur Ak, Zafer Gulbas. Nuclear Medicine Applications in Hemato-Oncology. Turk J Hematol 2003;20:89-211.
Ilknur Ak Sivrikoz (1), Havva Uskudar Teke (2), Zafer Gulbas (2)
(1) Department of Nuclear Medicine, Eskisehir Osmangazi University, School of Medicine, Eskisehir, Turkey
(2) Department of Haematology, Eskisehir Osmangazi University, School of Medicine, Eskisehir, Turkey
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|Title Annotation:||Images in Hematology|
|Author:||Sivrikoz, Ilknur Ak; Teke, Havva Uskudar; Gulbas, Zafer|
|Publication:||Turkish Journal of Hematology|
|Date:||Dec 1, 2010|
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