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Specialized proteins may be detected in blood of people with Alzheimer's.

Specialized proteins may be detected in blood of people with Alzheimer's. Specialized brain proteins that are involved in the removal of damaged nerve cell materials may be detected in the blood of people who were diagnosed with mild cognitive impairment or dementia due to Alzheimer's disease. In a select group of people who later developed dementia, the levels of the lysosomal proteins were abnormal while the individuals still had no problems with memory or thinking skills, according to a study published online in Neurology.

The researchers looked at four proteins in blood exosomes that come from lysosomes. Lysosomes act as a sort of recycling and disposal center for cells. In each case, the level of protein was significantly different for the healthy controls than for those with dementia --both before and after symptoms developed. For three of the proteins, the people with dementia had significantly higher levels; for one, the people with dementia had significantly lower levels.

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Title Annotation:Alzheimer's Disease
Publication:Medical Laboratory Observer
Article Type:Brief article
Date:Aug 1, 2015
Words:157
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