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Smoking associated with increased risk of multiple sclerosis.

Smoking is associated with an increased risk of multiple sclerosis, investigators reported after analyzing date from the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHS II). The NHS enrolled 121,700 women aged 30 to 55 years at baseline in 1976, while the NHS II enrolled 116,671 women aged 25 to 42 years at baseline in 1989. Smoking history was evaluated at baseline and updated on biennial questionnaires. A total of 315 bases of definite or probable MS were documents .during 18 and six years of follow-up in the NHS and NHS II, respectively. Compared with women who never smoked, relative incidence rates of MS were higher among current smokers (1.6; 95 percent confidence interval [Cl], 1.2-2.1) and past smokers (1.2; Cl, 0.9-1.6) after adjustment for age, latitude, and ancestry. The relative incidence rate increased with cumulative smoking exposure. "Although the biologic basis for the link between smoking and MS remains to be eluci dated, these results suggest that smoking may increase the risk of developing MS," the researchers concluded (Hernan MA, et al. Am J Epidemiol 2001:154;69-74).
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Title Annotation:Nurses' Health Study report
Publication:Medical Laboratory Observer
Article Type:Brief Article
Geographic Code:1USA
Date:Sep 1, 2001
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