Smoking and chronic rhinitis: effects of nasal irrigations with sulfurous-arsenical- ferruginous thermal water. a prospective, randomized, double-blind study.
Keywords: Chronic Rhinitis in Smokers; Thermal Water Nasal Washing; Rhinomanometry; Nasal Cytology; Olfactory Threshold
Introduction and Objectives
Smoking is a self-destructive behavior (1) that is known to induce remodeling of the lower airways, leading to squamous metaplasia, but little is known about its effects on the nose and paranasal sinuses (2). Smoking is a strong independent risk factor of olfactory impairment (3) probably as consequence of anatomical changes that occur in the olfactory mucosa, such as squamous metaplasia (4) and a reduction in the number and size of the olfactory vessels and cilia (5). Nasal irrigations are often mentioned as measures for treating sinonasal inflammations. Unfortunately, studies conducted on the benefits of nasal irrigations have often been small and poorly controlled, and their conclusions have not always been evidence-based (6). The purpose of our study was to compare the effects of nasal irrigations with sulfurousarsenical-ferruginous thermal water or isotonic sodium chloride solution in smokers with non-allergic chronic rhinosinusitis, based on clinical and olfactory evidences.
Materials and Methods
The present was a prospective, randomized, double-blind study performed in a tertiary academic referral center. Seventy smokers with non-allergic chronic rhinitis were enrolled. Nasal endoscopy, rhinomanometry, nasal cytology and odor threshold measurements were performed in subjects randomized to daily nasal irrigations with either thermal water or isotonic sodium chloride solution for 1 month.
Immediately after the treatment, the thermal water irrigations revealed a positive pharmacological action, judging from a tendency towards lower nasal resistances (p=0.07), and larger numbers of ciliated cells in the patients treated (p=0.003). Endoscopic findings in the thermal water group were still better than in the control group a further two months later (p=0.03).
Our results indicate that nasal irrigations with thermal water had a good effect on endoscopic objective signs, nasal resistances and epithelial trophism.
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Staffieri A (1), Marioni G (1), Staffieri C (1), Lionello M (1), Ottaviano G (1)
(1)Department Neurosciences. Section of Otolaryngology. University of Padova. Italy firstname.lastname@example.org
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|Title Annotation:||Scientific Sessions: Health Benefit--Session 02; texto en ingles|
|Author:||Staffieri, A.; Marioni, G.; Staffieri, C.; Lionello, M.; Ottaviano, G.|
|Publication:||Anales de Hidrologia Medica|
|Date:||Dec 1, 2012|
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