Printer Friendly

Smoking 'raises potential for metastatic pancreatic cancer'.

Byline: ANI

Washington, July 28 (ANI): Exposure to nicotine through cigarettes can significantly elevate the risk of pancreatic cancer to become metastatic, say researchers.

Researchers from the Kimmel Cancer Centre at Jefferson claim that isoform (variant type) of a protein called osteopontin might be a key to increased metastasis potential.

Dr Hwyda Arafat, an associate professor of Surgery at Jefferson Medical College of Thomas Jefferson University and a member of the Jefferson Pancreatic, Biliary and Related Cancers Centre said that nicotine promotes the expression osteopontin, and high levels of osteopontin have been reported in pancreatic ductal carcinoma (PDA).

During the study, the researchers analysed PDA samples and confirmed that the isoform, called OPNc, was also expressed on invasive PDA lesions.

Previous studies have shown that OPNc is expressed in several invasive cancers, and supports metastatic behavior.

The researchers correlated OPNc expression with the patients' smoking history.

OPNc expression was found on 87 percent of the invasive PDA lesions analysed, of which 73 percent were from smokers.

The OPNc expression also correlated with higher expression levels of osteopontin.

"This is the first time a relationship between nicotine and OPNc expression has been identified," said Arafat.

"These data are very exciting because now we can evaluate OPNc as a prognostic and diagnostic marker of invasive PDA lesions.

"Because of the lower expression levels of OPNc in non-smokers, OPNc may be regulated by nicotine, which is another novel finding of this study.

"The exact role of OPNc in PDA remains to be defined, but it could provide a unique potential target to control pancreatic cancer aggressiveness, especially in people who smoke cigarettes," she added.

The study is published in journal Surgery. (ANI)

Copyright 2009 Asian News International (ANI) - All Rights Reserved.

Provided by Syndigate.info an Albawaba.com company
COPYRIGHT 2009 Al Bawaba (Middle East) Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Asian News International
Date:Jul 28, 2009
Words:296
Previous Article:Only 5.2 percent of Pakistan forested, say scientists.
Next Article:Edgbaston curator says Hauritz will be 'a waste' on a seamer friendly pitch.
Topics:


Related Articles
Current issues in the treatment of pancreatic cancer.
American Society of Clinical Oncology (ASCO).
Cancer vaccines lead to long-term survival for skin cancer patients.
Common diabetic therapy reduces pancreatic cancer risk.
New advance in pancreatic cancer.
Abnormal genes in DNA repair may help predict pancreatic cancer risk.
Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute...

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters