Printer Friendly

Sinonasal intestinal-type adenocarcinoma.

Adenocarcinoma accounts for 10 to 20% of all primary malignant tumors of the nasal cavity and paranasal sinuses. (1) A type of adenocarcinoma called intestinal-type adenocarcinoma--so called because its histologic pattern is similar to that of an adenocarcinoma of the colon--accounts for 3 to 4% of all sinonasal malignancies. (2) Intestinal-type adenocarcinoma occurs sporadically as an occupational hazard of inhaling wood dust; it is most common in men 50 to 60 years of age. (3,4)

We evaluated a 56-year-old man who had a proven histologic diagnosis of sinonasal intestinal-type adenocarcinoma. The patient had been treated at another institution with chemo- and radiotherapy 6 months prior to the current admission. He came to our institution with signs of recurrence and a change in mental status. Areview of his original computed tomography (CT) scan (figure) revealed the presence of a large, destructive lesion that involved the sinonasal area and extended into the anterior cranial fossa, a significant degree of associated vasogenic edema in the adjacent frontal lobes of the brain, and signs of hemorrhage. A recent chest x-ray revealed multiple metastatic lesions in both lungs. Of interest, the patient was a furniture worker, and he had a 15-year history of exposure to wood dust. No evidence of gastrointestinal or colonic malignancy was noted.


Histologically, an intestinal-type adenocarcinoma can be confused with metastatic disease from the gastrointestinal tract. Among other sites from which neoplasms metastatic to the sinonasal area originate are the kidneys, lungs, breasts, testes, uterus, thyroid, adrenal glands, skin, and pancreas. Intestinal-type adenocarcinoma must also be pathologically differentiated from mucoepidermoid carcinoma and low-grade adenocarcinoma. (1) Sinonasal melanoma, aggressive fungal infections, and hemorrhagic metastatic lesions could have similar imaging characteristics, as occurred in our patient.


(1.) Sklar EM, Pizarro JA. Sinonasal intestinal-type adenocarcinoma involvement of the paranasal sinuses. AJNR Am J Neuroradiol 2003:24:1152-5.

(2.) Sanz JJ, Martinez R Aguilar E et al. [Sinonasal intestinal-type adenocarcinoma: Report of 7 cases]. Acta Otorrinolaringol Esp 2000;51:599-602.

(3.) Steinhart H, Bohlender J, Pahl S, et al. A second primary intestinal-type adenocarcinoma of the sinonasal tract induced by wood dust. Rhinology 2000;38:204-5.

(4.) Moor JC, Moor JW, Scott E Mitchell DA. Mucinous intestinal type adenocarcinoma of the sinonasal tract secondary to passive wood dust inhalation: Case report. J Craniomaxillofac Surg 2004;32: 228-32.

Enrique Palacios, MD, FACR; Rafael Rojas, MD

From the Department of Radiology, Tulane University Medical Center (Dr. Palacios), and the Department of Radiology, Louisiana State University Health Sciences Center (Dr. Rojas), New Orleans.
COPYRIGHT 2006 Vendome Group LLC
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2006, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:IMAGING CLINIC
Author:Rojas, Rafael
Publication:Ear, Nose and Throat Journal
Geographic Code:1U7LA
Date:Sep 1, 2006
Previous Article:Olfactory neuroblastoma.
Next Article:Facial sarcoidosis presenting as atypical facial pain.

Related Articles
Pedunculated cribriform adenocarcinoma of the base of the tongue.
Blindness: a sequela of sinonasal small cell neuroendocrine carcinoma.
Sinonasal tract, glomangiopericytoma (hemangiopericytoma).
Metastasis of colonic adenocarcinoma to the external ear canal: an unusual case with a complex pattern of disease progression.
Recurrent polymorphous low-grade adenocarcinoma manifesting as a sinonasal mass: a case report.
Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location.

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters