Printer Friendly

Single gene mutations linked to lung disease risk.

Byline: ANI

Washington, Dec 22 (ANI): People with single-gene mutations that cause them to have abnormally low levels of the protein alpha-1 antitrypsin are highly susceptible to emphysema-a progressive lung disease that causes severe shortness of breath.

Previous attempts to correct single-gene defects that cause lung disease by gene transfer have failed to achieve sustained gene expression in the mouse lung.

However, researchers at Boston University School of Medicine, have now developed an approach that enabled them to attain sustained in vivo expression of normal human alpha-1 antitrypsin at levels able to improve emphysema in mice.

Led by Darrell Kotton, the scientists introduced gene-carrying lentiviral vectors into the windpipe of mice.

They found that they selectively and efficiently transferred the genes they were carrying to resident cells known as alveolar macrophages.

These cells were long-lived and continued to express the transferred genes for at least two years.

In a mouse model of emphysema, introduction into the windpipe of lentiviral vectors carrying the gene responsible for making normal human alpha-1 antitrypsin led to sustained alpha-1 antitrypsin expression in the lung and reduced disease.

Therefore, the authors concluded that targeting genes to alveolar macrophages provides a way to achieve sustained gene expression in the lung and suggest that this might provide a therapeutic approach for overcoming overcome lung diseases caused by single-gene defects, for example emphysema caused by alpha-1 antitrypsin deficiency. (ANI)

Copyright 2009 Asian News International (ANI) - All Rights Reserved.

Provided by an company
COPYRIGHT 2009 Al Bawaba (Middle East) Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Asian News International
Date:Dec 22, 2009
Previous Article:'Prescription drugs found in Brittany Murphy's bedroom'.
Next Article:Carla Bruni gives street side tramp 100 euros everyday.

Terms of use | Privacy policy | Copyright © 2022 Farlex, Inc. | Feedback | For webmasters |