Printer Friendly

Sienna Biopharmaceuticals announces biopsy data from Phase 2b SNA-120 trial.

Sienna Biopharmaceuticals announced biopsy data from its recent Phase 2b clinical trial with SNA-120, the company's Phase 3 topical, non-steroidal Tropomyosin receptor kinase A, or TrkA, inhibitor under investigation for the treatment of psoriasis. Biopsy analyses were conducted at The Rockefeller University on 22 subjects, and included immunohistochemistry, or IHC, MicroArray and quantitative Reverse Transcription Polymerase Chain Reaction, or qRT-PCR. Specifically, the immunohistochemistry analysis showed meaningful and statistically significant improvement in the epidermal thickness at Week 12, supporting the effect of SNA-120 on keratinocyte hyperproliferation and inflammation. In addition, the data demonstrated a statistically significant reduction in T cell and dendritic cell counts, confirming an immune response to treatment with SNA-120. In MicroArray analyses, SNA-120 was also observed to affect most of the key inflammatory pathways in psoriasis in a statistically significant manner when compared to vehicle at Week 12. In the qRT-PCR analysis, SNA-120 demonstrated substantial, statistically significant gene expression improvements in key cytokines that play an important role in psoriasis pathogenesis, including IL-23, IL-12, IL-17A and IFNg, among other cytokines, in PASI 75 responders and even led to restoration to non-lesional expression levels, further validating the strong pharmacological effect of SNA-120.

COPYRIGHT 2019 The Fly
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2019 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:The Fly
Date:May 14, 2019
Previous Article:Sonos to integrate Google Assistant into sound experience.
Next Article:Tyler Technologies signs $7.2M agreement with Commonwealth of the Bahamas.

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters