Printer Friendly

Sickle mice turn anemic.

Sickle mice turn anemic

The race to develop an animal model for sickle cell anemia headed into the final stretch this week as researchers reported genetically engineering the first laboratory animals displaying symptoms of the hereditary disease. Previous experiments had yieldded mice whose red blood cells contained the human gene for sickle cell anemia but who failed to show any signs of the disease (SN: 1/20/90, p.45).

Thomas M. Ryan of the University of Alabama Schools of Medicine and Dentistry at Birmingham and his colleagues started by adding the human gene for sickle cell anemia to mouse embryos. As in previous efforts, the mice expressed the abnormal hemoglobin that is the hallmark of the disease, but they also produced moderate amounts of normal mouse hemoglobin, staving off the illness. Ryan's group overcome this obstacle by breeding these mice with others harboring a genetic disease called thalassemia, which prevents production of normal hemoglobin.

Offspring from these crosses have clinical profiles resembling those of humans with sickle cell anemia. They exhibit mild anemia and enlarged spleens, and their blood cells sickle under low-oxygen conditions. The hybrid mice may prove useful in tests of new anti-sickling drugs and gene therapies, the researchers assert in the Feb. 2 SCIENCE.
COPYRIGHT 1990 Science Service, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1990, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:sickle cell anemia research
Publication:Science News
Date:Feb 3, 1990
Previous Article:Cold dark matter builds a great wall.
Next Article:Making molecules that copy themselves.

Related Articles
Sudden death tied to sickle-cell trait.
Breaking the sickle cycle: potential treatments emerge for sickle cell anemia.
Brain risk seen in sickle cell kids.
Scientists create sickle-celled mouse.
Trading mouse blood for human blood.
Cephalosporin-resistant pneumococci and sickle cell disease.

Terms of use | Privacy policy | Copyright © 2018 Farlex, Inc. | Feedback | For webmasters