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Set low threshold for appendectomy in pregnant women.

PASADENA, CALIF. -- The diagnosis of appendicitis can, of course, be exquisitely difficult in a nonpregnant patient. Pregnancy only makes the task more daunting.

However, the challenge must be met because early diagnosis and prompt surgery may mean the difference between life and death for both the mother and the fetus, said Dr. J. Gerald Quirk, who is professor and chairman of obstetrics, gynecology, and reproductive medicine at the State University of New York at Stony Brook.

"The risks of temporizing appendicitis in pregnant women are quite grave," he warned at a meeting of the Obstetrical and Gynecological Assembly of Southern California.

Approximately 1 in 1,000 pregnancies are complicated by appendicitis, noted Dr. Quirk. Appendectomy confirms the disease in two-thirds to three-fourths of patients.

Unfortunately, perforation is not an uncommon result of delay, with dire consequences. While fetal mortality occurs as a result of unperforated appendicitis in 3%-5% of cases, a perforated appendix is associated with the much higher fetal mortality rate of 20%-30%.

Maternal mortality, seen in approximately 0.1% of cases of unperforated appendicitis, rises precipitously to 4% with perforation.

The threshold for surgery should therefore be low, and increasingly so as the pregnancy progresses, since perforation is twice as common in the third trimester as it is in the first or second. "What you're doing is just increasing the risks ... by waiting."

And still, in part out of reluctance to operate unnecessarily, "We are loathe to make the diagnosis and a lot of surgeons are loathe to act on the diagnosis," he said.

In fact, when special accommodations are made for physiologic changes associated with pregnancy, uncomplicated surgery and anesthesiology are not thought to be linked to adverse perinatal outcomes, said Dr. Quirk.

"In most cases, I think one can be assured that what's best for mom is best for the fetus."

It is not surgery that poses the greatest risk, but, in the words of Dr. E.A. Babler in 1908, "[the mortality of appendicitis is] the mortality of delay."

Uncertainty drives that delay, inasmuch as many of the classic signs and symptoms may not be present or may be confusing in the pregnant patient, and the differential diagnosis of appendicitis is long and complex. (See box.)

The location of the appendix varies during different stages of pregnancy. "What we do know is that it moves around," he said.

Direct abdominal tenderness is a fairly reliable sign of appendicitis during pregnancy, but rebound tenderness is much less reliable, because the enlarged uterus shields the abdominal wall. Rectal tenderness is frequently absent, said Dr. Quirk.

Anorexia, present in nearly all nonpregnant patients with appendicitis, occurred in only one- to two-thirds of pregnant patients in a 1975 study from Parkland Hospital in Dallas, he noted. In early pregnancy, anorexia may be associated with morning sickness, further complicating its usefulness as a contributor to a diagnosis of appendicitis.

Dr. Quirk said a urinalysis showing many white cells but no bacteria may reinforce the diagnosis of appendicitis in a pregnant woman, because periureteritis can develop over the right ureter.

Ultrasound or spiral CT imaging may be helpful, but imaging is not always reliable. In any case, a surgical consult should be obtained immediately and the decision to operate made promptly. Also, perioperative antibiotics should be administered.

General anesthesia is generally well-tolerated in pregnancy; laparoscopy or laparotomy appear to be equally safe. The incision generally is made over the point of maximal tenderness, or at the midline if the diagnosis is seriously in doubt or if diffuse peritonitis might be present.

The table should be tilted 30 degrees to the left, and uterine manipulation minimized. Some institutions advocate external fetal monitoring.

Following surgery, Dr. Quirk recommends monitoring the uterus for contractions. The mother should ambulate early and be kept well hydrated. During rest, the patient should maintain the tilt position.

Because the diagnosis is so difficult, negative appendectomies can be expected. Acceptable rates are considered to be 25%-35% in early pregnancy and more than 40% in the second and third trimesters, "as the consequences of delay are so severe," he said.
Differential Diagnosis

Nonobstetric Conditions Obstetric Conditions

Urinary calculi Preterm labor

Cholelithiasis Abruptio placentae

Cholecystitis Chorioamnionitis

Bowel obstruction Adnexal torsion

Gastroenteritis Ectopic pregnancy

Mesenteric adenitis Pelvic inflammatory disease

Colonic carcinoma Round ligament pain

Rectus hematoma Uteroovarian vein rupture

Acute intermittent porphyria Carneous degeneration of myomas

Perforated duodenal ulcer Uterine rupture (placenta percreta;
 rudimentary horn)


Meckel's diverticulum

Source: Dr. Quirk


Los Angeles Bureau
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Title Annotation:Obstetrics
Author:Bates, Betsy
Publication:OB GYN News
Date:Apr 15, 2006
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