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Scientists taking steps to degrade or eliminate gliadin from foods.

"Not only do patients with celiac disease experience diarrhea, but some develop anemia due to iron deficiency or malabsorption of folio acid or vitamin B12. In most individuals, the diagnosis of celiac disease is made by serologic testing; however, in some cases endoscopy and biopsy of the small intestine is necessary. Celiac disease is effectively treated by elimination of wheat, barley, and rye from the diet, but in a small minority of patients with refractory disease, steroids or immunosuppressant drugs are needed. In the future, it may be possible to treat celiac patients with a diet incorporating genetically engineered wheat lacking the gluten protein, gliadin. Investigators are also developing a combination of enzymes to degrade gliadin that would enable patients to consume glutencontaining foods."

ROGER A. LIDDLE MD, Professor Medicine--Gastroenterology; Chief, Division of Gastroenterology, Duke

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Title Annotation:THE VIEW FROM DUKE
Author:Liddle, Roger A.
Publication:Duke Medicine Health News
Date:Nov 1, 2009
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