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Scientists Develop Gel-Based Delivery System For Stem Cell -Derived Factors.

WINSTON-SALEM, N.C., May 31, 2019 -- Scientists here have further advanced a promising approach to finding a treatment for acute kidney injury using therapeutic factors produced by stem cells by creating a more efficient delivery method that would improve tissue regeneration.

Wake Forest Institute for Regenerative Medicine (WFIRM) researchers wanted to determine if any of the growth factors could lead to kidney function recovery.

They developed a gel-based system that contained a cocktail of stem cell derived growth factors.

"The results indicate that stem cell-secreted factors can mitigate kidney injury, and a well-controlled delivery system is needed to achieve maximized and sustained beneficial outcomes," said James Yoo, lead author.

Increasing incidence of acute kidney injury is contributing to the global health burden of chronic kidney disease.

More than 30 million American adults are affected by the disease and millions more are at risk of developing it, according to the National Kidney Foundation.

The current management for kidney failure is dialysis or organ transplantation.

One possible approach for the treatment of kidney injury is to regenerate damaged tissues using therapeutic cells and cellular products.

Using a preclinical model of kidney failure to test the feasibility of the controlled delivery, stem cell-derived conditioned medium was physically encapsulated within the gel and the release of the biological factors was assessed.

The researchers injected the growth factor gel into the model and observed significant improvement of kidney function over seven days using blood analysis.

"We found that using a growth factor cocktail significantly enhanced cell proliferation and survival in vitro, leading to a more rapid functional recovery," said co-author Sunil George.

Yoo said that future research will also help determine if stem cell-derived conditioned medium with a sustained and controlled delivery system, can be developed as a therapy that could block the progression of acute kidney injury to chronic kidney disease.

Citation: Hyung Eun Yim et al., Controlled Delivery of Stem Cell-Derived Trophic Factors Accelerates Kidney Repair After Renal Ischemia-Reperfusion Injury in Rats. Stem Cells Translational Medicine, 2019; DOI: 10.1002/sctm.18-0222


Contact: James J. Yoo,

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Title Annotation:Advanced Stem Cell Technology
Publication:Stem Cell Research News
Date:Jun 3, 2019
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