SUCCESSFUL TREATMENT OF ACUTE DISSEMINATED ENCEPHALOMYELITIS (ADEM) BY PROMPT USAGE OF IMMUNOGLOBULINS --CASE REPORT AND REVIEW OF THE LITERATURE.
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated, inflammatory, demyelinating disease that predominantly affects the white matter of the brain and spinal cord. The disease manifests as acute encephalopathy associated with multifocal neurological deficits (1-3). Although it can occur at any age, ADEM is most common in childhood and young adulthood. It most commonly affects children between ffth and eighth year of life (4-6). The disease usually has a monophasic course, although it can manifest by multiple relapses (7). ADEM usually occurs several days to several weeks after a viral infection, although the cases after bacterial infection are reported (8). Clinical presentation of ADEM may resemble other demyelinating diseases such as a multiple sclerosis (MS), neuromyelitis optica (NMO) and transverse myelitis (TM). Reliable diagnostic criteria for distinguishing these diseases have not been established yet.
In patients with ADEM, magnetic resonance imaging (MRI) of the brain shows hyperintense lesions on fluid-attenuated inversion recovery (FLAIR) and T2-weighted MRI, and has an important role in diagnosing the disease (9,10).
In the treatment of ADEM high doses of corticosteroids, plasmapheresis and immunoglobulins are used (11,12).
We report a case of an adult female patient with ADEM who fully recovered after prompt administration of methylprednisolone and intravenous immunoglobulins (IVIG).
A 30-year-old female patient was admitted to the hospital with a difuse headache accompanied by nausea, diplopia and instability while walking. She had no past medical history. A week before admission, she had a cough occasionally, without fever. In neurological status, a lag of the left eye on upward gaze, right abducens paresis, horizontal nystagmus on vertical gaze, vertical nystagmus on upward gaze, and diplopia in all directions of gaze, as well as truncal ataxia were observed. Soon she became somnolent with psychomotor agitation, followed by spontaneous extensional cramps. On admission, computed tomography (CT) of the brain was normal. Analysis of the cerebrospinal fluid (CSF) showed pleocytosis (316/[micro]L; normal 0-5 cells/[micro]L), increased lactate levels (4.3 mmol/L; normal 1.1-2.4 mmol/L) and increased total protein content (1780.5 mg/L; normal 450/mg/L). Polymerase chain reaction (PCR) for herpes simplex virus (HSV) type I and II was negative, as well as oligoclonal bands. Serologic tests of CSF for neurotropic viruses and Borrelia burgdorferi were also negative. MRI of the brain showed multiple lesions of the white matter supratentorially and infratentorially in both hemispheres (Fig. 1). Urgently, two hours after admission to the hospital, methylprednisolone at a dose of 500 mg/day intravenously was administered for five days, and then followed by oral methylprednisolone therapy in gradually lowering doses for four weeks. Also, IVIG at a dose of 0.4 g/kg were administered for seven days. Acyclovir at a dose of 750 mg 3 times daily was administered on the first day only, until the results of PCR for HSV type I and II were obtained. At discharge, neurological status showed vertical nystagmus and mild dystaxia. MRI two weeks after the onset of clinical symptoms showed significant regression of changes described above (Fig. 2). Six weeks after the onset of symptoms, neurological status of the patient was normal, and so were MRI findings (Fig. 3). Somatosensory and visual evoked potentials were also normal.
Acute disseminated encephalomyelitis is an autoimmune encephalomyelitis with disseminated lesions of the white matter resulting from inflammatory demyelination (2,13,14). The estimated incidence of ADEM is 0.8/100 000/year. Clinically, it is characterized by acute or subacute onset of multifocal neurological deficits that usually have a monophasic course (1,4,15,16). However, relapses are reported (1,17,18), making distinguishing it from MS harder (18-20).
Various combinations of motor, sensory, visual and cognitive symptoms may be part of a wide range of clinical manifestations of ADEM, but it usually begins with common symptoms such as fever, malaise, myalgia, headache and vomiting (4,21). Movement disorders occur in 60%, acute hemiplegia in 76%, ataxia in 18%-65%, cranial nerve palsy in 22%-45%, vision loss in 23%, convulsions in 13%-35%, paraparesis and paraplegia in 24%, speech disorders in 5%-21% of patients, while impairment of consciousness, from lethargy to coma, as well as respiratory failure have been reported in 11%-16% of cases (4,9,22-24).
According to the results of previous studies, three categories of ADEM are differentiated: (1) monophasic ADEM, the first clinical event develops within three months, and any new or changing symptoms within this three-month period is considered as one event; (2) recurrent ADEM (RDEM) represents a new clinical event that occurs three months after the initial attack and involves the same symptoms and the same MRI findings that occurred during the initial attack; and (3) multiphasic ADEM refers to one or more relapses that involve new areas of the central nervous system (CNS) from the initial or previous attacks. Relapses occur at least three months after the initial ADEM (25).
Acute disseminated encephalomyelitis and MS share a great deal of pathological and clinical similarities, but it is still unclear why some patients are affected by fulminant monophasic inflammatory process, whereas other patients suffer chronic polyphasic process (18). In both diseases, autoantibodies to specific myelin proteins and lipids contribute to the disease pathogenesis (26-29). The seasonal distribution of ADEM, with the peak incidence in winter and spring, supports an etiological link with infectious disease (4,18). An autoimmune attack on the CNS can be triggered by infection, and the possible mechanism is molecular mimicry (30). This process has an important role in MS too.
The histopathologic hallmark of ADEM is perivenular demyelination (31-34), whereas MS is characterized by sharply limited, confluent demyelinated plaques (35). Some authors suggest that this histopathologic difference is the possible gold standard in diagnosing and distinguishing ADEM from MS (21).
Magnetic resonance imaging has an important role in the diagnosis of acute CNS diseases affecting white matter. CT usually shows no abnormality in ADEM (36,37). MRI often shows increased T2-weighted signal in multifocal areas in the CNS white matter, with or without involvement of gray matter. ADEM lesions are unclear and not sharply defined, unlike MS plaques, which have defined borders (18,38). Overlap in lesion location and distribution between ADEM and MS was found in earlier studies, however, some features of ADEM that are unusual in MS were highlighted as well, such as relative sparing of the periventricular white matter or gray matter involvement (39). For ADEM, absolute and relative sparing of the periventricular white matter on MRI is typical and is presented in 78% of patients. However, 22% of patients with ADEM have periventricular lesions indistinguishable from those seen in MS (18). Tintore et al. compared MRI criteria to predict conversion to MS and found positive predictive value for increased number of lesions, infratentorial lesions and periventricular lesions (40). A c cording to some studies, corpus callosum long axis lesions, along with the finding of only well-defined lesions, were completely specific predictors of relapse and MS over a mean of 4.9 years. However, the difficulty of using initial MRI in identifying patients with an increased risk of relapsing disease and MS is highlighted by the fact that only 21% of patients presenting with the first episode of demyelination have this finding (38). Due to the relatively nonspecific findings, even when MRI seems typical of either ADEM or MS, a wide range of differential diagnosis of inflammatory demyelinating diseases needs to be carefully considered (39). Therefore, in verifying the diagnosis of ADEM or suggesting alternative pathology, MRI criteria should be considered in combination with clinical criteria (21).
In both ADEM and the first presentation of MS, intrathecal synthesis of oligoclonal bands may occur. The absence of oligoclonal bands in CSF should be shown in convalescent testing in ADEM, while the oligoclonal bands may remain in MS (23).
Some studies showed that these two diseases differ in immunoglobulin subtype (28,29,41-45). Van Haren et al. found ADEM to be characterized by IgG autoantibodies targeting myelin basic protein, proteolipid protein, myelin-associated oligodendrocyte basic glycoprotein and alpha-B-crystallin, whereas MS was characterized by IgM autoantibodies targeting myelin basic protein, proteolipid protein, myelin-associated oligodendrocyte basic glycoprotein, and oligodendrocyte specific protein. These profiles of serum autoantibodies may be useful in distinguishing ADEM and MS, but further clinical studies have to confirm it (46).
Cerebrospinal fluid analysis must exclude infectious meningoencephalitis before diagnosing ADEM. Analysis of CSF in ADEM usually shows minor and unspecific changes. In some cases, it may reveal mild pleocytosis, with lymphocytes, monocytes and sometimes plasma cells, usually between 10 to 50 cells/[micro]L, no more than 100/[micro]L. Total protein content is also increased but usually below 1000 mg/L (47).
At present, there is no controlled trial concerning treatment of ADEM because of the low incidence of ADEM, therefore clinical data are the only basis for therapies for ADEM (47). In some patients, spontaneous improvement has been reported (48). Usage of high dose corticosteroids, IVIG and plasmapheresis is based on the analogy of the ADEM pathogenesis with that of MS (11,12). Therapy of ADEM usually starts with intravenous methylprednisolone at a dosage of 10-30 mg/kg/day for 3-5 days (4,18,49-51). Full recovery has been reported in 50%-80% of patients with this modality of treatment. According to some studies, methylprednisolone treated patients had significantly better outcome when compared with those treated with dexametahasone (52). In cases of insufficient response or contraindications to corticosteroids, IVIG at a dosage of 0.4 g/kg/day for 5 days or 1 g/kg/2 days are administered (53). There are several cases in which full recovery following administration of IVIG have been reported. Assa et al. describe a case of two children with ADEM where full recovery occurred after IVIG administration at a dosage of 2 g/kg for five days (54). Kleinmann and Brunquell describe an 11-year-old boy with ADEM who responded rapidly to the course of IVIG (55). A case of an 8-year-old boy with multiple episodes of disseminated demyelination of both hemispheres, cerebrum and brain stem who initially responded to corticosteroid therapy but developed exacerbations after cessation of treatment has been reported. He improved rapidly after administration of IVIG and no relapses are reported (56).
In our case, prompt administration of high dose methylprednisolone and IVIG led to complete clinical and radiological recovery. Follow up MRI of the brain was scheduled at 6 months after discharge.
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USPJESNO LIJECENJE AKUTNOG DISEMINIRANOG ENCEFALOMIJELITISA (ADEM) PRAVODOBNOM PRIMJENOM IMUNOGLOBULINA --PRIKAZ SLUCAJA I PREGLED LITERATURE
A. Repic-Bulicic, P. Filipovic-Grcic, E. Jadrijevic, P. Jurinovic i M. Titlic
Akutni diseminirani encefalomijelitis (ADEM) je upalna demijelinizirajuca bolest sredisnjega zivcanog sustava koja obicno pogada djecu i mlade odrasle osobe. Najcesce ima monofazni tijek, iako su zabiljezeni i relapsi bolesti. Klinicka prezentacija bolesti ukljucuje encefalopatiju i multifokalne neuroloske deficite. Pouzdani kriteriji za dijagnozu ADEM-a nisu utvrdeni i ponekad ga je tesko razlikovati od prve atake multiple skleroze, osobito kod odraslih. Dijagnoza ADEM-a temelji se na klinickim, radioloskim i laboratorijskim nalazima. U lijecenju ADEM-a primjenjuju se visoke doze kortikosteroida, plazmafereza i imunoglobulini. Prikazujemo slucaj mlade odrasle bolesnice kod koje je potpun oporavak uslijedio nakon pravodobne primjene visoke doze metilprednizolona i imunoglobulina.
Kljucne rijeci: Encefalomijelitis, akutni diseminirani; Imunoglobulini; Kortikosteroidi; Metilprednisolon; Prikazi slucaja
Ana Repic-Bulicic, Petar Filipovic-Grcic, Eni Jadrijevic, Pavao Jurinovic and Marina Titlic
Department of Neurology, Split University Hospital Centre, Split, Croatia
Correspondence to: Eni Jadrijevic, MD, Department of Neurology, Split University Hospital Centre, Spinciceva 1, HR-21000 Split, Croatia
Received August 17, 2015, accepted March 16, 2016
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|Title Annotation:||Original Scientific Paper|
|Author:||Repic-Bulicic, Ana; Filipovic-Grcic, Petar; Jadrijevic, Eni; Jurinovic, Pavao; Titlic, Marina|
|Publication:||Acta Clinica Croatica|
|Date:||Mar 1, 2019|
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