Risk factors for bilateral anterior cruciate ligament injuries/Faktori rizika za nastanak obostrane povrede prednjeg ukrstenog ligamenta.
The annual incidence of unilateral anterior cruciate ligament injury (ACL rupture) in general population ranges between 0.01 and 0.08%, while it is significantly higher in sports active population, being 1.5-1.7% [1-5]. The frequency of nonsimultaneous bilateral ACL injuries ranges from 1.1% up to even 14% of the total number of ACL injuries [5-11]. Simultaneous ruptures are very rare, and they are reported in the literature only as individual cases [4, 12-15]. The risk of injuring the other knee is even greater than the risks for primary rupture, and the second injury happens most often within the first three years after the first operation [6-9].
The causes of bilateral ACL injuries have not been explained sufficiently although there are various assumptions. Specific internal factors which are being intensively studied include: anthropometric, biomechanical, neuromuscular, anatomical, hormonal, and genetic risks [3, 16, 17]. Reduced width of femoral intercondylar notch, increased posterior tibial slope, bad neuromuscular control, ligament laxity, increased body mass index (BMI), female sex and the valgus position of the knee are linked with an increased risk of ACL injury [3, 16, 17].
This study has been aimed at analyzing possible causes of bilateral ACL ruptures and identifying risk factors on our specimen of patients, which should result in the prevention of bilateral injuries.
Material and Methods
Having been approved by the Ethics Committee of Clinical Center of Vojvodina, this retrospective study was performed at the Department of Orthopedic Surgery and Traumatology in Novi Sad. The study sample included 32 of 50 patients operated for bilateral ACL ruptures in the period from January 01, 2003 until December 31, 2012, who had given their consent to participate in this study. The average time of monitoring from the knee operations to the check-up was 4.9 years. The respondents were 5 women and 27 men, whose average age was 30.46 years (ranging from 19 to 55 years).
A questionnaire was designed and sent by e-mail to all patients, who were asked to provide data on the amount of time before the first and the second injury, between the injuries, between the injuries and surgical interventions, between the interventions and return to trainings and competitions. They also provided information on their sports activities and activities in their daily life.
The following parameters were included in the more detailed coverage of data for each patients: age structure, gender structure, family history of the same injury, height, body mass, amount of time spent on training before the injury, the amount of time between the first injury and operations, the amount of time between the first injury and return to training, the amount of time between the first operation and return to competition, the amount of time between the two injuries, the amount of time between the first operation and injuring the other knee, the amount of time between injuring the other knee and the second operation, the amount of time between injuring the other knee and return to training, the amount of time between injuring the other knee and return to competition, dominant leg, the achieved level of physical activities after the second operation.
The mean values, standard deviation, minimum and maximum were analyzed within descriptive statistics. The following statistical analyses were used: Spearman and Pearson's coefficient correlation and T-test for independent samples.
During the study period lasting for ten years, 2168 unilateral ACL ruptures were operated. Fifty patients with reconstructed bilateral ruptures were among them, the incidence being 2.3%.
Out of 32 patients, 14 patients injured the right knee first and 16 patients injured first the left one, while both knees were simultaneously injured in two cases. The left leg was dominant in 19 patients (for jumping), and the right one was dominant in 13 patients. No statistically significant correlation was observed between the age of patients and their level of activity, nor the effect of the dominant leg on bilateral ACL injuries. The correlation of age and the activity level was F (2.29)=1.59, p=.221 (p>.05).
The periods between injuries and operations are shown in Table 1.
The injuries happened during the sports activities in all patients: 16 (75%) in competition, 8 during the training (25%) and 8 in recreational sporting activities (25%). The association between the type of sport and bilateral ACL rupture is shown in Graph 1 and the competition level of sports activities of patients is given in Graph 2.
ACL and meniscus injuries during the first and contralateral knee injuries are shown in Table 2.
According to the answers in the questionnaire, 87.5% of respondents returned to trainings and 75% to competitions after the first operation. However, that percentage was lower after the second ACL reconstruction, being 81.2% and 53.1% of those who returned to trainings and to competitions (matches), respectively (Graph 3).
While the risk factors, etiology and mechanisms of primary ACL injuries have been widely studied, reasons for ACL ruptures of the contralateral knee are not clearly defined, although those injuries are not rare. The most voluminous study was published by a Swedish group of authors  thanks to the National Register of Knee Ligaments Injuries . Out of 9061 reconstructed ACL in the study sample, 270 bilateral reconstructions (3%) were done. Souryal et al. , Myklebust et al.  and Falstrom et al.  reported 4%, 9%, and 12% of bilateral injuries, respectively. The incidence increases with the length of the monitoring period of the patients, so in our sample it resembles the Swedish register and amounts to 2.3%.
While in some countries, such as Japan, bilateral ACL injuries are dominant in women , in Scandinavian countries sexes are almost equally represented [7, 9]. In our study, as well as in some others  men are most affected. The above mentioned does not suggest that men represent a group of athletes at risk, only that they are operated 2-8 times more often than women [19-22]. The group at highest risk for ACL injury is young, sports active population. Women are at 2-10 times greater risk than men, depending on the type of sport [3, 6, 18]. The reasons for epidemic appearance of ACL injuries among women in the world lie in the anatomic differences between gender: size of Q angle, increased valgus of knee joint, narrow intercondylar notch, wider pelvis, impact of estrogen hormone on ligaments during menstruation cycle, general laxity of ligaments and different time of contractions between anterior and posterior groups of thigh muscles [3, 6, 18].
Branch et al.  used robotics to measure and compare rotatory stability of knee joints without ACL rupture and with bilateral ruptures. The latter had significantly increased internal and decreased external rotation of tibia. Both internal and external rotation was increased in women compared to men. Rotatory instability may cause a simultaneous rupture of ACL, medial meniscus and medial colateral ligament because those injuries most often happen during forced valgus, moderate flexion and rotation of tibia .
According to our previous studies , the following factors did not significantly influence injuring ACL in 450 operated patients: type of sport shoes, warming, genetic predisposition and taking daily therapy. Injuries occurred more often during competitions, at the end of matches, in activities without contact with other competitors, during landing or sudden change of direction, on dry surfaces, in athletes who had not prepared well.
Today, anatomic variations of knee joint are in the focus as risk factors, so we have found that patients with increased posterior tibial slope are at a greater risk of ACL rupture . A narrow femoral intercondylar notch can also represent an anatomic risk factor for bilateral ACL rupture [10, 18].
Sward et al.  believe that the most prominent risk factor for a contralateral ACL injury is return to a high (competitive) level of physical activity. Our results are in agreement with the above mentioned because 75% of our operated patients returned to competition level of activities after the first operation, and then had another knee injury within the first 4 years after the primary operation. Most authors [5, 9, 25] confirm the above mentioned time frame, while Orchard et al.  found that the greatest risk factor for a contralateral ACL injury was a history of an ACL reconstruction in the previous 12 months.
Contralateral ACL rupture is most commonly associated with younger people, athletes under 20 years of age [9, 10]. We have observed, as Falstrom et al. did , that the second injury happened at somewhat older age, the average being 30.5 years of our patients and 29.1 years of theirs. Due to the fact that sports career is on the wane in those years, contralateral knee injury in the fourth decade may mean an end of career, while this happens less frequently in the second decade of life. In addition, every second active athlete has cartilage damage in the fourth decade , which can cause pain and lasting disruption of sports activities. Statistical analysis considering the correlation between the participants' age and the subjective level of physical activities which the respondents have achieved after the second knee surgery does not show a significant difference. The correlation is extremely low, so we can say that there is no connection between the age and activity level.
Family history may be considered a possible risk factor for bilateral ACL injuries according to some literature data. Although this issue is still being debated, no consensus has been reached. While some authors advocate this theory strongly [17, 27], the authors of this paper as well as others have not found the correlation [5, 10, 27]. Flynn et al.  found that patients having the history of ACL ruptures in their family: in the first generation (parent, brother or sister, child), the second (brothers and sisters of their parents) or in the third, are at a risk twice higher of injuring their ACL than general population without family history of injuries. Our study could not confirm this claim, because only four of our patients had ACL injuries in their family history (two fathers, a brother, and a sister), which is statistically insignificant representation.
Studies which have found a significant correlation between the side of the injured extremity and bilateral ACL injury are rare. Although there are some authors who believe that the reconstruction of nondominant limb is a potential predictor of contralateral ACL injury , we have not observed such a correlation.
The choice of graft can also be a risk factor. Leys and Sward et al. [8, 25] have concluded that reconstruction with bone-to-bone (BTB) graft carries a greater risk for bilateral ACL rupture (26%) than hamstring tendons (12%). Ardernord et al.  claim that graft harvesting of hamstring tendons from the contralateral unharmed knee significantly increased this risk. This probably weakens the function of the healthy knee resulting in it being injured later because the tendons cannot regenerate during a short period of time until the next rupture. However, the majority of studies [9, 21, 30] have proved that the choice of graft does not affect the bilateral ACL ruptures significantly. Our previous studies have also failed to find the correlation between the choice of graft and ACL re-ruptures [19, 21]. The cause may lie in the fact that ACL are reconstructed with BTB graft in professional athletes, while hamstrings tendons are usually applied in women and those who go in for recreational sporting activities, which impose less burden on the operated and uninjured knees.
The structure of sporting activities which the respondents were engaged in only confirmed our earlier epidemiological studies . Intensive sports that involve movements of pivoting, forced valgus and anterior translation of tibia during one-leg landing represent activities of high risk for ACL rupture. The fact that in Vojvodina [20-22] 37-50% of patients get injured in football (soccer) only reflects sports preference of young population in Serbia due to the popularity of that sport among young professionals and recreational activities among the middle-aged population. Football is also the most prominent sport in this study, and the second and third place is taken by basketball and handball, respectively. In the study done by Souryal et al. , American football (rugby) was in the first place with 25.6%, followed by basketball (20.7%) and soccer (11%) This is in accordance with the findings of our studies. The difference is only in the fact that rugby is more popular sport in North America than soccer. Swedish authors  consider handball to be sport of a high risk due to rapid change of movement direction and pivoting, which says more about popularity of that sport in Scandinavian countries. Authors from Japan think that basketball and gymnastics are sports carrying the highest risks .
The most prominent risk factor for a contralateral ACL injury is returning to a high level of activity during intense trainings and competitions  which include sports with a lot of jumping, pivoting, leap aside and change in movement direction. This is in line with our results since only four participants (13%) did not return to training after the initial injury, and all the others resumed the previous sporting activities at the level of training or competitions. According to earlier results, the most commonly injured athletes are those who are active in sports between 11 and 20 years of age, most often in competitive matches, and considerably less in friendly matches and during training. The parts of competition that have the highest risk are its middle part and end of match . Competitive athletes, who train at least once a day most often for 90 minutes, are at a higher risk of injuring ACL. Our results showed that the patients who were at the competitive level of sports activities were mostly present in the structure of our participants (15 of them), while 8 of them were injured while training.
By correlating the associated injuries during the second knee injury and the reached level of physical activity in our study group, it has been proved that meniscus ruptures do not play a crucial role in restitution of activities. Statistical parameters do not show any statistically significant difference. The reason for such a result is again significant disproportions in the representation and associated absence of ruptures within the group, as well as the high percentage of those respondents who were not able to provide the information on associated knee injuries. Only 9.4% of the respondents had the rupture of medial meniscus, 9.4% had the lateral meniscus rupture, and 3.1% suffered from both menisci rupture simultaneously. As many as 25% of participants did not know if they had injury of menisci, while 53.1% of them had an isolated ACL rupture. Faltstrom et al.  found ruptures of medial meniscus in 15.4% of cases during initial injuries and 31.1% during the contralateral injuries . Associated lateral meniscus injury was reported in 15.4% of initial ACL injuries and in 13.1% of contralateral ones. Both menisci got injured simultaneously during the initial rupture in 4.6% of cases and in 3.3% of cases during contralateral ACL rupture. Ardernord et al.  also concluded that the previous meniscal and chondral injuries were not predictors of future contralateral ACL reconstruction, although they noted significantly higher percentages than we did (40% menisci and 27.5% chondral lesions).
Since there are several aspects of doing physical activities, our study and similar ones need more detailed questionnaires to analyze the length of training before injuries, as well as the intensity and phases of sports activities (warming up, training, activity in other types of sports in relation to the primary one) in order to check the data obtained for that particular aspect of training-competitive process. Low statistical significance in the correlation between the associated initial and contralateral injuries with the reached level of physical activities after the second operations leads to the conclusion that it is necessary to study this issue on a sample greater than 32 patients, which is the main drawback of this study. The existence of a National Register, similar to the Swedish one, would certainly lead to a more comprehensive analysis.
Anterior cruciate ligament rupture of contraleteral knee occurs in young active athletes most often within the first four years after the initial reconstruction.
Sex, side of extremity, genetic predisposition, type of sport, concomitant injuries and choice of graft do not affect bilateral injury.
Returning to the same or higher level of sports activities after the first reconstruction is one of the preconditions for the appearance of the same injury of the second knee.
Determination of predisposing factors could help in preventing bilateral anterior cruciate ligament injuries.
Abbreviations ACL --anterior cruciate ligament injury BMI --body mass index BTB --bone-to-bone
Rad je primljen 11. II 2015.
Recenziran 23. II 2015.
Prihvacn za stampu 16. III 2015.
[1.] Moses B, Orchard J. Systematic review: annual incidence of ACL injury and surgery in various populations. Res Sports Med. 2012;20:157-79.
[2.] Swedish ACL Register - a Joint ISAKOS and ESSKA Project. Annual Report 2012.
[3.] Beynnon BD, Ettlinger CF, Johnson RJ. Epidemiology and mechanisms of ACL injury in alpine skiing. In: TE Hewett, SJ Shultz, LY Griffin, editors. Understanding and Preventing Non-contact ACL Injuries. Champaign, IL: American Orthopaedic Society for Sports Medicine, Human Kinetics; 2007. p. 183-8.
[4.] Maywood RM, Hechtman KS. Simultaneous bilateral anterior cruciate ligament tears. Am J Knee Surg. 1995;8:134-6.
[5.] Salmon L, Russell V, Musgrove T, Pinczewski L, Refshauge K. Incidence and risk factors for graft rupture and contralateral rupture after anterior cruciate ligament reconstruction. Arthroscopy. 2005;21(8):948-57.
[6.] Myklebust G, Bahr R, Engebretsen L, et al. Clinical, functional and radiological outcome 6-11 years after ACL injuries in team handball players: a follow-up study. Am J Sports Med. 2003;31:981-9.
[7.] Faltstrom A, Hagglund M, Kvist J. Patient-reported knee function, quality of life, and activity level after bilateral anterior cruciate ligament injuries. Am J Sports Med. 2013;41(12):2805-13.
[8.] Sward P, Kostogiannis I, Roos H. Risk factors for a contralateral anterior cruciate ligament injury. Knee Surg Sports Traumatol Arthrosc. 2010;18(3):277-91.
[9.] Andernord D, Desai N, Bjornsson H, Gillen S, Karlsson J, Kristian Samuelsson. Predictors of contralateral anterior cruciate ligament reconstruction: a cohort study of 9061 patients with 5-year follow-up. Am J Sports Med. 2014;20(10):1-8.
[10.] Souryal TO, Moore HA, Evans JP. Bilaterality in anterior cruciate ligament injuries: associated intercondylar notch stenosis. Am J Sports Med. 1988;16(5):449-54.
[11.] Wright RW, Magnussen RA, Dunn WR, Spindler KP. Ipsilateral graft and contralateral ACL rupture at five years or more following ACL reconstruction: a systematic review. J Bone Joint Surg Am. 2011;93(12):1159-65.
[12.] Lukas C, Bauer G. The simultaneous bilateral ACL-rupture --a rare injury. Aktuelle Traumatol. 2004;34(2):100-2.
[13.] Stilger VG. Simultaneous bilateral anterior cruciate ligament tears in a collegiate gymnast (Note). Athletic Therapy Today. 2000;5(3):56-7.
[14.] Sanchis-Alfonso V, Tinto-Pedrerol M. Simultaneous bilateral anterior cruciate ligament tears in a female beginner skier. Knee Surg Sports Traumatol Arthrosc. 2000;8(4):241-3.
[15.] Tifford CD, Jackson DW. Simultaneous bilateral anterior cruciate ligament ruptures in a cheerleader. Arthroscopy 2001;17(4):E17.
[16.] Labella CR, Hennrikus W, Hewett TE. Anterior cruciate ligament injuries: diagnosis, treatment, and prevention. Pediatrics. 2014;133(5):1437-50.
[17.] Goshima K, Kitaoka K, Nakase J, Tsuchiya H. Familial predisposition to anterior cruciate ligament injury. Sports Med Arthrosc Rehabil Ther Technol. 2013;1(2):62-6.
[18.] Motohashi M. Profile of bilateral anterior cruciate ligament injuries: a retrospective follow-up study. J Orthop Surg (Hong Kong). 2004;12(2):210-5.
[19.] Milankov M, Milicic A, Savic D, Stankovic M, Ninkovic S, Matijevic R, et al. Revision anterior cruciate ligament reconstruction due to knee instability. Med Pregl. 2007;60(1112):587-92.
[20.] Ristic V, Ninkovic S, Harhaji V, Milankov M. Causes of anterior cruciate ligament injuries. Med Pregl. 2010;63(78):541-5.
[21.] Ristic V, Ninkovic S, Harhaji V, Stankovic M, Savic D, Milankov M. Reconstruction of ACL by using two different techniques. Med Pregl. 2010;63(11-12):845-50.
[22.] Ninkovic S, Milicic A, Savic D, Stankovic M, Radic S, Milankov M. Uporecivanje klinickih i radiografskih rezultata rekonstrukcije prednjeg ukstenog ligamenta kolena. Med Pregl. 2006;59:421-5.
[23.] Branch TP, Browne JE, Campbell JD, Siebold R, Freedberg HI, Arendt EA, et al. Rotational laxity greater in patients with contralateral anterior cruciate ligament injury than healthy volunteers. Knee Surg Sports Traumatol Arthrosc. 2010;18:1379-84.
[24.] Ristic V, Maljanovic M, Pericin B, Harhaji V, Milankov. The relationship between posterior tibial slope and anterior cruciate ligament iinjury. Med Pregl. 2014;67(7-8):216-21.
[25.] Leys T, Salmon L, Waller A, Linklater J, Pinczewski L. Clinical results and risk factors for reinjury 15 years after anterior cruciate ligament reconstruction. a prospective study of hamstring and patellar tendon grafts. Am J Sports Med. 2012;40:595-605.
[26.] Orchard J, Seward H, McGivern J, Hood S. Intrinsic and extrinsic risk factors for anterior cruciate ligament injury in Australian footballers. Am J Sports Med. 2001;29:196-200.
[27.] Anderson AF, Lipscomb AB, Liudahl KJ, Addlestone RB. Analysis of the intercondylar notch by computed tomography. Am J Sports Med. 1987;15(6):547-52.
[28.] Flynn RK, Pedersen CL, Birmingham TB, Kirkley A, Jackowski D, Fowler PJ. The familial predisposition toward tearing the anterior cruciate ligament: a case control study. Am J Sports Med. 2005;33(1):23-8.
[29.] Brophy RH, Schmitz L, Wright RW, et al. Return to play and future ACL injury risk after ACL reconstruction in soccer athletes from MOON group. Am J Sports Med. 2012;40(11):2517-22.
[30.] Bourke HE, Salmon LJ, Waller A, Patterson V, Pinczewski LA. Survival of the anterior cruciate ligament graft and the contralateral ACL at a minimum of 15 years. Am J Sports Med. 2012;40(9):1985-92.
Vladimir RISTIC (1), Sinisa RISTIC (2), Mirsad MALJANOVIC (1), Vladimir DAN (3,5), Vukadin MILANKOV (3,5) and Vladimir HARHAJI (4,5)
General Hospital Subotica, Department of Orthopedics and Traumatology (1)
Elementary and High School "Milan Petrovic", Novi Sad (2)
Institute for Child and Youth Health Care of Vojvodina, Novi Sad Department of Pediatric Surgery (3)
Clinical Centre of Vojvodina, Novi Sad, Department of Orthopedics and Traumatology (4)
University of Novi Sad, Faculty of Medicine (5)
Corresponding Author: Dr Vladimir Ristic, Opsta bolnica Subotica, Odeljenje za ortopediju i traumatologiju, 24000 Subotica, Izvorska 3, E-mail: firstname.lastname@example.org
Table 1. Time of ACL injuries Tabela 1. Vreme povrecivanja prednjeg ukrstenog ligamenta Time/Vreme Average/Prosek 1st injury--1st operation 25 days--7 years 10.2 months 1. povreda--1. operacija 25 dana -7godina 10,2 meseci 1st injury--2nd .injury 9 months--15 years 4.34 years 1. povreda--2. povreda 9 meseci--15 godina 4,34 godine 2nd injury--2nd operation 5 days--4 years 9.1 months 2. povreda--2. operacija 5 dana--4 godine 9,1 meseci Table 2. ACL and meniscus injuries during the first and contralateral knee injuries Tabela 2. Udruzene povrede prilikom inicijalne i povrede prednjeg ukrstenog ligamenta kontralateralnog kolena Injury Povreda Isolated ACL/Samo Both menisci prednji ukrsteni Oba meniskusa ligament The first/Prva 15 3 The second/Druga 17 1 Injury Povreda Medial meniscus Lateral meniscus Unutrasnji Spoljasnji meniskus meniskus The first/Prva 6 3 The second/Druga 3 3 Graph 1. Sport that caused bilateral ACL rupture Grafikon 1. Vrsta sporta koja je dovela do obostrane povrede prednjeg ukrstenog ligamenta Skiing Skijanje 6% Basketball Kosarka 25% Volleyball Rukomet 13% Soccer Fudbal 37% Other Ostalo 19% Note: Table made from pie chart.
|Printer friendly Cite/link Email Feedback|
|Author:||Ristic, Vladimir; Ristic, Sinisa; Maljanovic, Mirsad; Dan, Vladimir; Milankov, Vukadin; Harhaji, Vla|
|Date:||May 1, 2015|
|Previous Article:||Bacterial infections in patients with liver cirrhosis/Bakterijske infekcije kod bolesnika sa cirozom jetre.|
|Next Article:||Development of plastic surgery/Razvoj plasticne hirurgije.|