Printer Friendly

Risk factors and clinical outcomes of patients with node-positive muscle-invasive bladder cancer.

Radical cystectomy and lymphadenectomy is a standard treatment for patients with high-grade, invasive bladder cancer. Although the absolute limits of lymphadectomy at the time of surgery have not been precisely defined, there is a growing body of evidence to suggest that an extended lymph node dissection may be beneficial for staging and survival in both node-negative and -positive bladder cancer patients. For lymph node-positive patients, several prognostic factors have been identified to provide risk stratification and direct the need for adjuvant treatment. These include: the pathological stage of the bladder tumor, extent of the lymphadenectomy and nodal tumor burden. The concept of lymph node density has also been identified as a prognostic factor. The literature and data on the extent of lymphadenectomy will be reviewed as well as the current prognostic variables and the benefits of adjuvant chemotherapy.

Expert Rev Anticancer Ther. 2008 Jul;8(7):1091-101
COPYRIGHT 2009 LE Publications, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:Combidex
Publication:Life Extension
Article Type:Report
Geographic Code:1USA
Date:Mar 1, 2009
Previous Article:Colorectal carcinoma: selected issues in pathologic examination and staging and determination of prognostic factors.
Next Article:Prognostic factors in patients with carcinoma of the vulva--our own experience and literature review.

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters