Printer Friendly

Research suggests Vitamin D deficiency and muscle fatigue link.

VITAMIN D may be linked to muscle efficiency and could improve skeletal muscle function, according to new research.

The findings may explain the physical fatigue commonly experienced by patients with vitamin D deficiency, with broad implications for a large section of society.

Vitamin D is a hormone produced in the skin using energy from sunlight. Vitamin D deficiency is a significant public health problem as diagnosed cases are on the rise and the hormone is essential for good bone health.

Alongside poor bone health, muscle fatigue is a common symptom in vitamin D deficient patients.

This fatigue could be due to a problem in the mitochondria: the "power stations" within each cell of the body.

Mitochondria use glucose and oxygen to make energy in a form that can be used to run the cell (an energy-rich molecule called ATP).

Muscle cells need large amounts of ATP for movement and they use phosphocreatine as a ready and available energy source to make ATP.

The mitochondria also replenish this phosphocreatine store after muscle contraction.

Researchers investigated phosphocreatine recovery times in patients with vitamin D deficiency. The team found that phosphocreatine recovery significantly improved after the patients took a fixed dose of oral vitamin D for 10 to 12 weeks.

All patients reported an improvement in symptoms of fatigue following supplementation.

Study leader Dr Akash Sinha said: "This is the first time a link has been shown between vitamin D status and muscle aerobic function. To do so we used a non-invasive scan to get a unique biochemical perspective on muscle mitochondrial metabolism during exercise: a window into what is really going on in the muscle as it works "Patients with vitamin D deficiency often experience symptoms of muscle fatigue. Our findings in a small group of patients with very low vitamin D levels show muscle efficiency significantly improves when vitamin D status is improved."
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2013 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:Features
Publication:Western Mail (Cardiff, Wales)
Date:Mar 18, 2013
Previous Article:Nurses get IT on course; ADVERTISING FEATURE.
Next Article:Coffee and tea linked to reduction of strokes.

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters