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Research and Markets: Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions.

DUBLIN -- Research and Markets ( has announced the addition of John Wiley and Sons Ltd's new book "Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions" to their offering.

This second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found.

The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the catalytic step fits into the overall synthesis, or competition with other synthetic approaches, as well as the typical problems encountered in the various phases, including finding/developing the catalyst and optimization of the process or choice of equipment. Both successful and unsuccessful approaches to solve these problems are described.

Key Topics Covered:

PART I: New Processes for Existing Active Compounds (APIs)

* Some Recent Examples In Developing Biocatalytic Pharmaceutical Processes

* Enantioselective Hydrogenation: Applications In Process R&D Of Pharmaceuticals

* Chiral Lactones By Asymmetric Hydrogenation ? A Step Forward In (+)-Biotin Production

* Biocatalytic Asymmetric Oxidation For The Production Of Bicyclic Proline Peptidomimetics

* The Asymmetric Reduction Of Heterocyclic Ketones ? A Key Step In The Synthesis Of Potassium-Competitive Acid Blockers (P-Cabs)

PART II: Processes for Important Building Blocks

* Application Of A Multiple-Enzyme System For Chiral Alcohol Production

* Chemoenzymatic Route To The Side-Chain Of Rosuvastatin

* Asymmetric Hydrogenation Of A 2-Isopropylcinnamic Acid Derivative En Route To The Blood Pressure-Lowering Agent Aliskiren

* Asymmetric Phase-Transfer Catalysis For The Production Of Non-Proteinogenic Alpha-Amino Acids

* Development Of Efficient Technical Processes For The Production Of Enantiopure Amino Alcohols In The Pharmaceutical Industry

* The Asymmetric Hydrogenation Of Enones ? Access To A New L-Menthol Synthesis

* Eliminating Barriers In Large-Scale Asymmetric Synthesis

* Catalytic Asymmetric Ring Opening: A Transfer From Academia To Industry

* Asymmetric Baeyer-Villiger Reactions Using Whole-Cell Biocatalysts

* Large-Scale Applications Of Hydrolases In Biocatalytic Asymmetric Synthesis

* Scale-Up Studies In Asymmetric Transfer Hydrogenation

* 2,2?,5,5?-Tetramethyl-4,4?-Bis(Diphenylphoshino)-3,3?-Bithiophene: A Very Efficient Chiral Ligand For Ru-Catalyzed Asymmetric Hydrogenations On The Multi-Kilograms Scale

* The Power Of Whole-Cell Reaction: Efficient Production Of Hydropyroline, Sugar Nucleotides, Oligosaccharides, And Dipeptides

* Enantioselective Ketone Hydrogenation: From Research To Pilot Scale With Industrially Viable Ru ? (Phosphine-Oxazoline) Complexes

PART III: Processes for New Chemical Entities (NCEs)

* Enabling Asymmetric Hydrogenation For The Design Of Efficient Synthesis Of Drug Substances

* Scale-Up Of A Telescoped Enzymatic Hydrolysis Process For An Intermediate In The Synthesis Of A Factor Xa Inhibitor

* An Efficient, Asymmetric Synthesis Of Odanacatib, A Selective Inhibitor Of Cathepsin K For The Treatment Of Osteoporosis, Using An Enzyme-Mediated Dynamic Kinetic Resolution

* Biocatalytic Routes To The Gpiib/Iiia Antagonist Lotrafiban, Sb 214857

* Discovery And Development Of A Catalytic Asymmetric Conjugate Addition To Ketoesters To Nitroalkenes And Its Use In The Large-Scale Preparation Of Abt-546

* The Kagan Oxidation ? Industrial-Scale Asymmetric Sulfoxidations In The Synthesis Of Two Related Nk1/Nk2 Antagonists

* Large-Scale Application Of Asymmetric Phase-Transfer Catalysis For Amino Acid Synthesis

* Application Of Phase-Transfer Catalysis In The Organocatalytic Asymmetric Synthesis Of An Estrogen Receptor Beta-Selective Agonist

* Asymmetric Synthesis Of Hcvand Hpv Drug Candidates On Scale: The Choice Between Enantioselective And Diastereoselective Syntheses

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Publication:Business Wire
Date:Jul 28, 2010
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