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Research and Markets: Analysis of Top Oncology Drug Candidates in Phase III of Clinical Evaluation.

DUBLIN, Ireland -- Research and Markets ( has announced the addition of Large Pharma: 2004 A Year Of Progress to their offering.

The gross majority of all drugs, which reach late stage of development, are someway or another passed on to the large pharmaceutical companies because they hold the capital needed to conduct the expensive clinical trials as well as the regulatory commitment needed to gain an approval. In this report we analyse the progress made by the large pharmaceutical companies top oncology drug candidates whom have reached Phase III clinical evaluation. This report provides you with update information on the most recent advances made and the competitive struggle that exists between the large pharmaceutical companies.

Hallmarks of 2004 includes that BAY 43-9006 and CCI-779 were granted Fast Track Designition for treating patients with renal cell carcinoma. Fast Track Designition were also awarded to Xcytrin for treating patients brain metastases. In turn, Orphan Drug Status was granted to BAY 43-9006 for renal cancer, PI-88 for melanoma and Revlimid for myelodysplastic syndromes. Four FDA approvals were also reported during 2004. Avastin as well as Erbitux were both approved as treatment for colorectal cancer whereas Alimta was approved as treatment for mesothelioma. And very recently, Tarceva was approved as monotherapy to treat non-small cell lung cancer.

This report covers the following stories:

--Approval and New Development of Erbitux

--Two Drugs at War; Iressa versus Tarceva

--Breast Cancer Competition

--European Approval for Estrogen Receptor Downregulator

--Dual Kinase Inhibitor with Improved Effect in Breast Cancer

--Side effects & resistance

--Epothilone B analogues in Patients with Breast/Prostate Cancer

--Avastin safety warning unlikely limit use

--FDA backs drug for lung cancer treatment

--Late Stage Cancer Vaccine Back To The Bench

--Discontinued Phase III Studies: NSCLC

--New Therapeutic Option for Patients with Renal Cell Carcinoma

--Fast Track Status in Advanced Renal Cell Carcinoma

--Option For The Treatment of Colorectal Cancer

--New Drug to Replace Standard Chemotherapy in Colon Cancer?

--A Drug More Potent than Camptothecin

--Additional Revenues for Gleevec

--Overcoming Gleevec resistance

--Reactivating DNA-damaging in hypoxic tumors

--New agent with antimyeloma activity

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Publication:Business Wire
Date:Jan 20, 2005
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