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Research and Markets: ADME-Enabling Technologies in Drug Design and Development.

DUBLIN -- Research and Markets (http://www.researchandmarkets.com/research/c2s2d5/admeenabling_tech) has announced the addition of John Wiley and Sons Ltd's new report "ADME-Enabling Technologies in Drug Design and Development" to their offering.

A comprehensive guide to cutting-edge tools in ADME research

The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME).

ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings.

With over thirty contributed chapters by an international team of experts, the book provides:

- A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones

- Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies

- Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies

- Numerous figures and diagrams throughout the text

Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.

Key Topics Covered:

PART A ADME: OVERVIEW AND CURRENT TOPICS

* 1 Regulatory Drug Disposition and NDA Package Including MIST

* 2 Optimal ADME Properties for Clinical Candidate and Investigational New Drug (IND) Package

* 3 Drug Transporters in Drug Interactions and Disposition

* 4 Pharmacological and Toxicological Activity of Drug Metabolites

* 5 Improving the Pharmaceutical Properties of Biologics in Drug Discovery: Unique Challenges and Enabling Solutions

* 6 Clinical Dose Estimation Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation

* 7 Pharmacogenomics and Individualized Medicine

* 8 Overview of Drug Metabolism and Pharmacokinetics with Applications in Drug Discovery and Development in China

PART B ADME SYSTEMS AND METHODS

* 9 Solubility and Dissolution

* 10 Permeability and Transporter Models in Drug Discovery and Development

* 11 Methods for Assessing Blood & Brain Barrier Penetration in Drug Discovery

* 12 Techniques for Determining Protein Binding in Drug Discovery and Development

* 13 Reaction Phenotyping

* 14 Fast and Reliable CYP Inhibition Assays

* 15 Tools and Strategies for the Assessment of Enzyme Induction in Drug Discovery and Development

* 16 Animal Models for Studying Drug Metabolizing Enzymes and Transporters

* 17 Milk Excretion and Placental Transfer Studies

* 18 Human Bile Collection for ADME Studies

PART C ANALYTICAL TECHNOLOGIES

* 19 Current Technology and Limitation of LC-MS

* 20 Application of Accurate Mass Spectrometry for Metabolite Identification

* 21 Applications of Accelerator Mass Spectrometry (AMS)

* 22 Radioactivity Profiling

* 23 A Robust Methodology for Rapid Structure Determination of Microgram-Level Drug Metabolites by NMR Spectroscopy

* 24 Supercritical Fluid Chromatography

* 25 Chromatographic Separation Methods

* 26 Mass Spectrometric Imaging for Drug Distribution in Tissues

* 27 Applications of Quantitative Whole-Body Autoradiography (QWBA) in Drug Discovery and Development

PART D NEW AND RELATED TECHNOLOGIES

* 28 Genetically Modified Mouse Models in ADME Studies

* 29 Pluripotent Stem Cell Models in Human Drug Development

* 30 Radiosynthesis for ADME Studies

* 31 Formulation Development for Preclinical in vivo Studies

* 32 In vitro Testing of Proarrhythmic Toxicity

* 33 Target Engagement for PK/PD Modeling and Translational Imaging Biomarkers

* 34 Applications of iRNA Technologies in Drug Transporters and Drug Metabolizing Enzymes

Authors

Donglu Zhang.

Sekhar Surapaneni.

For more information visit http://www.researchandmarkets.com/research/c2s2d5/admeenabling_tech

Source: John Wiley and Sons Ltd
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Date:Jul 17, 2012
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