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Reproductive outcomes of office hysteroscopic metroplasty in women with unexplained infertility with dysmorphic uterus/Aciklanamayan infertilite ve dismorfik uterus olan hastalarda ofis histeroskopik metroplastinin ureme sonuclan.

Introduction

A dysmorphic uterus, which was formerly known as "T-shaped uterus" in the American Fertility Society classification of anomalies of the Mullerian duct, is denoted as a second-class (Class U1) uterine anomaly in the European Society of Human Reproduction and Embryology (ESHRE) and the European Society for Gynaecological Endoscopy (ESGE) (ESHRE/ESGE) consensus on the classification of congenital genital tract anomalies, and it leads to poor reproductive and obstetric outcomes (12). Although the prevalence of dysmorphic uterus is not yet known, the reproductive performance of a dysmorphic uterus after hysteroscopic metroplasty is poorly documented; only five trials have been reported to date (3-7). In the past, operative hysteroscopy for metroplasty was used to expand the uterine cavity; currently, office hysteroscopy with a bipolar system is used, which appears to have minimally invasive effects, thus making it feasible for metroplasty (7). The encouraging results of the case series of 114 women remain in small numbers in the literature (3-7). The correlation between dysmorphic uterus and infertility still remains enigmatic. No study has definitely defined such a uterus as being the primary reason for infertility. Although the poor obstetric outcomes of Mullerian anomalies are well-known issues, their reproductive performance in terms of infertility has been relatively ignored. Nevertheless, the lesser expansion of a unicornuate uterus is seen as the cause for infertility. The relationship between a dysmorphic uterus and infertility is not clarified exactly in the literature due to the absence of evidence on this topic. The aim of our study was to evaluate the effectiveness of hysteroscopic metroplasty on reproductive outcome in women with unexplained infertility with dysmorphic uteri.

Materials and Methods

This retrospective study was conducted at Baskent University, Adana Dr. Turgut Noyan Practice and Research Hospital, Clinic of Obstetrics and Gynecology, Division of Reproductive Medicine and In Vitro Fertilization (IVF) Unit. Records of women who underwent hysteroscopic metroplasty for dysmorphic uterus with unexplained infertility from January 2013 to January 2016 were investigated. Mild and/or severe male infertility factor, diminished ovarian reserve, history of endometriosis and/or endometrioma, and tubal pathologies, including bilateral tubal obstruction or hydrosalpinx were excluded and eligible women with unexplained infertility were analyzed. All of the included women were assessed in two groups as primary and secondary infertility. Institutional review board approval This study was approved by Baskent University Institutional Review Board and Ethics Committee approval (KA: 17/151-A) and supported by Baskent University Research Fond was obtained for this retrospective cohort study.

Pre-operative diagnosis

Infertile couples were admitted to Baskent University Division of Reproductive Medicine and IVF Unit. Medical history and ovarian reserve measured using the antral follicle count were evaluated, and hysterosalpingography (HSG) for the uterine cavity and tubal patency and sperm analysis were conducted. Unexplained infertility was defined as follows: unprotected intercourse for at least 1 year without conceiving with a normal ovarian reserve (i.e., antral follicle count over 4 in at least one functioning ovary with a regular menstrual cycle) and bilateral tubal patency observed on HSG and normal sperm analysis based on the World Health Organization 2010 criteria (8). Dysmorphic uterus, formerly known as "T-shaped uterus," was defined as a condensed lateral side uterine cavity observed using a properly performed HSG, in which the traction to the uterus was sufficient to expose the normal plain of the uterine cavity (Picture 1). The schematic view of the uterus revealed a T-shape, and the angle of the narrowed side wall was almost 90[degrees] (Picture 1). We were unable to perform 3D ultrasonography owing to the lack of this technology in our institution. There was no history of diethylstilbestrol (DES) exposure owing to the absence of DES use in Turkey. We think that the relationship between DES exposure and dysmorphic uterus remains speculative. Another issue associated with dysmorphic uterus class U1b, which is the infantile type, was that it could not be evaluated using HSG. This was a limitation of HSG. However, we did not experience any lateral wall perforation.

Operation

Sedation with proper a dosage of propofol and midazolam was applied to the women. After vaginal scrubbing with a povidone-iodine solution, the office hysteroscope was inserted in to the uterine cavity using a non-touch technique. Office hysteroscopy was performed at the early follicular phase (days 6-14) using a 5 mm diameter continuous-flow hysteroscope with an oval profile and a 30[degrees] fore-oblique telescope and a 5-Fr operating channel (Office Continuous Flow Operative Hysteroscopy 'size 5'; Karl Storz, Tuttlingen, Germany). Cavity distension was induced using an electronic irrigation and aspiration system (Endomat; Karl Storz, Tuttlingen, Germany) with NaCl 0.9%. A stable intrauterine pressure of ~40 mm Hg was obtained by setting the flow rate to 220-350 mm Hg; the negative pressure suction was set at 0.2 bar, and the pressure of irrigation was set at 100 mm Hg. After the evaluation of the uterine cavity, the lateral side walls were cut using a Bipolar Versapoint System (Gynecare Versapoint Bipolar Electrosurgery System, Ethicon, US) until the tubal orifice was visible from the isthmus. The video can be viewed at https://youtu.be/wVh9m0dxB2I. The operations were performed by four experienced surgeons. At the end of the operation, no anti-adhesive gel and/or intrauterine balloon was used. We did not record our operation duration; nevertheless, the mean duration of the operations was ~5 minutes.

Post-operative approach

After the operation, the patients were discharged on the same day. The patients were prescribed 2 mg estradiol valerate oral estrogen support for 3 weeks (Cyclo-progynova tb, Bayer, Turkey). After 2 menstrual cycles, HSG was repeated for the evaluation of the newly formed uterine cavity (Picture 1). All patients were counseled to prevent them from conceiving until the second HSG. After evaluation of the new cavity using the second HSG, all patients were advised to try to conceive without assisted reproductive technology (ART) support for at least 1 year.

Follow-up for the evaluation of reproductive outcomes

The reproductive outcomes were recorded using the delivery registry from our hospital database and via telephone interviews. Clinical pregnancy (CP) was defined as pregnancy diagnosed through ultrasonographic visualization of one or more gestational sacs or a positive blood human chorionic gonadotropin test result. The live birth rate (LBR) was noted as the delivery of at least one live born baby after 24 complete weeks of gestational age. The spontaneous abortion rate was defined as the spontaneous loss of a CP before 20 weeks of completed gestation. The delivery rate ending with live births at full term (37 weeks' gestation) was also recorded.

Statistical Analysis

The data are expressed as mean [+ or -] standard deviation. The baseline differences between the groups were analyzed using Student's t-test. Pearson's chi-square test and Fisher's exact test were used to compare the ratios between the groups. Time to pregnancy after metroplasty was measured using Kaplan-Meier survival analysis. A p value of <0.05 was considered statistically significant. The data were analyzed using the SPSS for Windows (version 23.0; SPSS, Inc., Chicago, IL).

Results

During the 3-year study period, 685 office hysteroscopies for dysmorphic uterus were performed to 272 women with unexplained infertility by our IVF department. The baseline characteristics of the patients are shown in Table 1. Of all the patients, 162 had primary infertility, and 110 had secondary infertility. The mean age and mean duration of infertility of the patients were similar. Forty-five women in the primary infertility group and 27 women in the secondary infertility group underwent an IVF/intracytoplasmic sperm injection (ICSI) cycle before metroplasty [27.8% (45/162) and 24.5% (27/110), respectively] (Table 1). In primary infertility group, 45 patients had IVF failures; 23 patients had a history of one cycle failure, 16 had two IVF/CSI failure cycles, and six patients had 3 IVF/ICSI failure cycles before metroplasty. In the secondary infertility group, 27 patients had a history of ART failures; 15 women had one IVF/ICSI failure, eight patients had two failure cycles, and four had three failure cycles. Seven of nine spontaneous pregnancies after metroplasty in the primary infertile women group had just one IVF failure and two patients had two failed IVF/ICSI cycles. In secondary infertile group, the number of spontaneous pregnancy after metroplasty in previous IVF failure cycles was six, four of which had one previous failure and two had 2 IVF/ICSI failures. The CPR and LBR after metroplasty are shown in Table 2. In the secondary infertility group, the miscarriage rate and ectopic pregnancy rate declined dramatically (p=0.01) (Table 2). Nine out of 45 patients (20%) in the primary infertility group and six out of 27 patients (22.2%) in the secondary infertility group with a history of IVF/ICSI failures successfully delivered subsequent to metroplasty through spontaneous pregnancies (Table 1). After metroplasty, the pregnancies of 44 patients in the primary infertility group and 24 patients in the secondary infertility group were successful with the first fresh IVF/ICSI cycle without waiting for spontaneous pregnancy. After the second HSG, the time to pregnancy was 5.8[+ or -]4.7 months in the spontaneous pregnancy group and 6.7[+ or -]5.7 months in the pregnancies with ART group (Figure1, 2). The time to pregnancy in the primary and secondary infertile groups was also similar (Table 2).

Discussion

Our study demonstrated that office hysteroscopic metroplasty of dysmorphic uterus might improve fertility, particularly in patients with unexplained infertility and with dysmorphic uterus, which was an ignored factor previously. Mullerian anomalies can impair obstetric outcomes because it can cause recurrent pregnancy loss (5-10%), as well as late miscarriage and preterm delivery (25%) (9,10). These adverse obstetric outcomes may be subsequent to restricted expansion of an abnormally small endometrial cavity (11). Increased contractility and decreased vascular perfusion of the fibrous uterine septum may also contribute (12). We hypothesize that the enlargement of the uterine cavity using hysteroscopic metroplasty might restore obstetric outcomes by increasing the possibility for embryo implantation by proper endometrial vascular perfusion together with decreased uterine contractility inducing fragility in a dysmorphic uterus. This hypothesis might be supported by the majority of metroplasty outcomes of uterine septum surgery even in an arcuate uterus in ART cycles (13,14). The higher prevalence of previous ectopic pregnancy in women with dysmorphic uterus was first reported by Fernandez et al. (6). Our study also demonstrated that women with secondary infertility with dysmorphic uteri have higher ectopic pregnancy rates (15.5%). After correction of the uterine cavity, the ectopic pregnancy rate dropped to the expected population. This increased rate of ectopic pregnancy might be explained by the increased uterine contractility and decreased endometrial implantation in a dysmorphic uterus. Due to a lack of adequate and credible data, we did not apply any adhesion prevention strategies, such as intrauterine gel or balloon. We evaluated the newly-formed cavity configuration using a second HSG and hence did not observe any adhesions. We did not encounter any complications from hypotonic solution use such as electrolyte changes and hyponatremia because we applied saline during metroplasty procedures. Throughout the 3 years of the study, we did not encounter any complications of hysteroscopy such as uterine perforation or excessive bleeding after the operation. As expected, there would be no further risk of cervical incompetency owing to the thinner hysteroscope, thus ruling out the need for cervical dilatation. The major limitation of this retrospective study is the absence of the confirmation of a narrowed cavity using 3D transvaginal ultrasonography. Although our diagnostic criterion was based only on HSG, despite HSG being superior for the confirmation of dysmorphic uterus, 3D ultrasonography was feasible and appeared to be accurate as. If we had the opportunity to evaluate dysmorphic uterus using 3D ultrasonography, we would have calculated the volume of the endometrial cavity and provided a cut-off volume to compare with that of fertile women's cavities. Although the importance of lateral wall thickness in dysmorphic uterus was included in the ESHRE/ESGE classification, the definitive ratio or thickness in the current literature was not mentioned. Furthermore, there is high intra/inter-observer variability in 3D ultrasonographic measurements of uterine wall thickness for uterine anomalies with conflicting data for their measurements owing to the inadequacy of the technique (15). Although the ESHRE/ESGE consensus definitive diagnostic criteria were demonstrated using the schematic view for dysmorphic uterus, we speculate that as a diagnostic tool, the combination of HSG and 3D ultrasonography will achieve significantly better outcomes, which might be highlighted by future trials. Our department is an endoscopic surgery and ART clinic to which women who have a potentially higher prevalence of uterine anomalies are referred (16). This is why the population ratio in this study seemed to be relatively higher. Furthermore, DES exposure was not documented in these women due to the absence of DES marketing in Turkey. In terms of obstetric outcomes, the risk associated with hysteroscopic metroplasty of dysmorphic uterus is the potential for placental adhesion owing to the possibility of electrosurgical injuries to the endometrium and myometrium. We had three different cases of placenta accreta that could be related to the intrauterine operation during the cesarean process. It is possible to see this type of potential adhesion even in the history of cesarean procedures conducted to date, hysteroscopic myomectomy, or any type of endomyometrial injury. The resultant outcomes at our department have been encouraging for fertility expectation in women with dysmorphic uterus. The ignored uterine-factor infertility must be considered in terms of dysmorphic uterus. The relationship between intrauterine adhesion and infertility seems to be similar to dysmorphic uterus related to lesser cavity volumes (17). Further, the subsiding rate of ectopic pregnancy and miscarriage is also optimizing evidence for enlargement of dysmorphic cavities. Future randomized controlled trials are needed to support the effectiveness of the operation.

Conclusion

Infertile women with dysmorphic uterus should be operated by hysteroscope to improve reproductive outcomes. Office hysteroscope is an alternative option in terms of non-invasive procedure.

Ethics

Ethics Committee Approval: This study was approved by Baskent University Institutional Review Board and Ethics Committee (KA: 17/151A) and supported by Baskent University Research Fond.

Informed Consent: Consent form was filled out by all patients.

Peer-review: Internally peer-reviewed.

Authorship Contributions

Surgical and Medical Practices: B.H., E.B.K., T.C., P.C.A., Concept: B.H., E.B.K., Design: B.H., G.D.D., Data Collection or Processing: G.D.D, S.S., Analysis or Interpretation: B.H., Literature Search: B.H., Writing: B.H., G.D.D.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study received no financial support.

References

(1.) Grimbizis GF, Gordts S, Di Spiezio Sardo A, Brucker S, De Angelis C, Gergolet M, et al. The ESHRE/ESGE consensus on the classification of female genital tract congenital anomalies. Hum Reprod 2013;28:2032-44.

(2.) No authors listed. The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, mullerian anomalies and intrauterine adhesions. Fertil Steril 1988;49:944-55.

(3.) Nagel TC, Malo JW Hysteroscopic metroplasty in the diethylstilbestrol-exposed uterus and similar nonfusion anomalies: effects on subsequent reproductive performance; a preliminary report. Fertil Steril 1993;59:502-6.

(4.) Katz Z, Ben-Arie A, Lurie S, Manor M, Insler V Beneficial effect of hysteroscopic metroplasty on the reproductive outcome in a T-shaped' uterus. Gynecol Obstet Invest 1996;41:41-3.

(5.) Garbin O, Ohl J, Bettahar-Lebugle K, Dellenbach P. Hysteroscopic metroplasty in diethylstilboestrol-exposed and hypoplastic uterus: a report on 24 cases. Hum Reprod 1998;13:2751-5.

(6.) Fernandez H, Garbin O, Castaigne V, Gervaise A, Levaillant JM. Surgical approach to and reproductive outcome after surgical correction of a T-shapeduterus. Hum Reprod 2011;26:1730-4.

(7.) Di Spiezio Sardo A, Florio P, Nazzaro G, Spinelli M, Paladini D, Di Carlo C, et al. Hysteroscopic outpatient metroplasty to expand dysmorphic uteri (HOME-DU technique): a pilot study Reprod Biomed Online 2015;30:166-74.

(8.) World Health Organization WHO laboratory manual for the examination and processing of human semen. World Health Organization, Geneva, 2010.

(9.) Acien P. Incidence of mullerian defects in fertile and infertile women. Hum Reprod 1997;12:1372-6.

(10.) Salim R, Regan L, Woelfer B, Backos M, Jurkovic D. A comparative study of the morphology of congenital uterine anomalies in women with and without a history of recurrent first trimester miscarriage. Hum Reprod 2003;18:162-6

(11.) Rackow B W, Arici A. Reproductive performance of women with mullerian anomalies. Curr Opin Obstet Gynecol 2007;19: 229-37.

(12.) Zreik TG, Troiano RN, Ghoussoub RA, Olive DL, Arici A, McCarthy SM. Myometrial tissue in uterine septa. J Am Assoc Gynecol Laparosc 1998;5:155-60.

(13.) Venetis CA, Papadopoulos S P, Campo R, Gordts S, Tarlatzis BC, Grimbizis G F. Clinical implications of congenital uterine anomalies: a meta-analysis of comparative studies. Reprod Biomed Online 2014;29:665-83.

(14.) Tomazevic T, Ban-Frangez H, Virant-Klun I, Verdenik I, Pozlep B, Vrtaznik-Bokal E. Septate, subseptate and arcuate uterus decrease pregnancy and live birth rates in IVF/ICSI. Reprod Biomed Online 2010;21:700-5.

(15.) Graupera B, Pascual MA, Hereter L, Browne JL, Ubeda B, Rodriguez I, et al. Accuracy of three-dimensional ultrasound compared with magnetic resonance imaging in diagnosis of Mullerian duct anomalies using ESHRE-ESGE consensus on the classification of congenital anomalies of the female genital tract. Ultrasound Obstet Gynecol 2015;46:616-22.

(16.) Jayaprakasan K, Chan YY, Sur S, Deb S, Clewes JS, Raine-Fenning NJ. Prevalence of uterine anomalies and their impact on early pregnancy in women conceiving after assisted reproduction treatment. Ultrasound Obstet Gynecol 2011;37:727-32.

(17.) Cholkeri-Singh A, Sasaki KJ. Hysteroscopy for infertile women: a review. J Minim Invasive Gynecol 2015;22:353-62.

[iD] Bulent Haydardedeoglu, [iD] Gulden Dogan Durdag, [iD] Seda Simsek, [iD] Pinar Caglar Aytac, [iD] Tayfun Cok, [iD] Esra Bulgan Kilicdag

Baskent University, Adana Dr. Turgut Noyan Practice and Research Hospital, Clinic of Obstetrics and Gynecology, Adana, Turkey

Address for Correspondence/Yazisma Adresi: Bulent Haydardedeoglu, MD, Baskent University, Adana Dr. Turgut Noyan Practice and Research Hospital, Clinic of Obstetrics and Gynecology, Adana, Turkey

Phone: +90 533 207 98 77 E-mail: bulenthaydar@yahoo.com ORCID ID: orcid.org/0000-0001-9873-754

Received/Gelis Tarihi: 21.05.2018

Accepted/Kabul Tarihi: 27.05.2018

DOI: 10.4274/tjod.30111
Table 1. Basal characteristics of the study groups

                                   Primary infertility
                                   (n=162)

Age                                30.53[+ or -]4.5
Duration of infertility             5.28[+ or -]3.54
Previous IVF failure number        27.8% (45/162)
Spontaneous LBR after metroplasty  18.5% (30/162)
IVF/ICSI LBR after metroplasty     20.4% (33/162)
Spontaneous LBR after metroplasty
with previous IVF failure          20% (9/45)

                                   Secondary infertility  p
                                   (n=110)

Age                                30.41[+ or -]4.66      0.36
Duration of infertility             5.71[+ or -]3.93      0.84
Previous IVF failure number        24.5% (27/110)         0.57
Spontaneous LBR after metroplasty  33.6% (37/110)         0.004
IVF/ICSI LBR after metroplasty     21.8% (24/110)         0.19
Spontaneous LBR after metroplasty
with previous IVF failure          22.2% (6/27)           0.52

IVF: In vitro fertilization, ICSI: Intracytoplasmic sperm injection,
LBR: Live birth rate

Table 2. The reproductive outcomes of the secondary infertility group

                            Preoperative    Primary infertility
                                            (n=162)

Pregnancy rate                              45.7% (74/162)
Miscarriage                 84.5% (93/110)  13.5% (10/74)
Ectopic pregnancy           15.5% (17/110)   1.4% (1/74)
Preterm delivery             0               2.7% (2/74)
Term delivery                0              82.4% (61/74)
Time to pregnancy (months)   -               6.2[+ or -]3.2

                            Secondary infertility  p
                            (n=110)

Pregnancy rate              55.4% (61/110)         -
Miscarriage                  9.8% (6/61)           <0.001
Ectopic pregnancy            1.6% (1/61)           <0.001
Preterm delivery             0                     NS
Term delivery               88.5% (54/61)          <0.001
Time to pregnancy (months)   6.3[+ or -]4.0         0.94

NS: Not significant
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Author:Haydardedeoglu, Bulent; Durdag, Gulden Dogan; Simsek, Seda; Aytac, Pinar Caglar; Cok, Tayfun; Kilicd
Publication:Turkish Journal of Obstetrics and Gynecology
Date:Sep 1, 2018
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