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Report on lysine study.

The leukemia-prone AKR mice that we have been feeding lysine and low arginine are surviving in a manner that encourages us to repeat the experiment and to do some additional variations of the study.

At the time of our deadline for this magazine, the mice receiving the highest amount of lysine and NO arginine were the winners, with 50 percent survival. The results to date are tabulated on the chart that follows.

The three-week-old mice were obtained from the Jackson Laboratories in Bar Harbor, Maine, and were randomly segregated into five groups. We began feeding the mice in late August 1983.

In view of the larger number of survivors of mice in groups being given the higher levels of lysine and lower arginine, it appears possible that lysine supplements may play a significant role in the suppression of the lethal effects of the mouse leukemia virus.

In our experiment, the amino-acid-defined pellets had been prepared with lysine hydrochloride, which meant that our mice were required to eat one molecule of hydrochloric acid for each molecule of lysine. Although this did not make a great deal of difference with low levels of lysine, the mice given the highest levels were getting a rather large amount of hydrochloric acid in their chow. In one of our new experiments, the mice are being given diets with the same levels of lysine as in our original study, but they will be fed pellets prepared with free-base lysine.

Leukemia-prone AKR mice are also being vaccinated with turkey-herpes virus, which is used commercially to vaccinate 24-hour-old chicks for leukemia-like diseases in chickens.
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Author:SerVaas, Cory
Publication:Saturday Evening Post
Article Type:column
Date:Sep 1, 1984
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