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Replacing viruses in gene therapy.

Replacing viruses in gene therapy

Transplanting bone marrow cells infected with gene-carryingviruses is an established method of introducing specific genetic material into an animal, but this approach to gene therapy also has its problems. The viruses may become activated and harm the host, or expression of the gene may not occur. An alternative, say researchers at Massachusetts General Hospital in Boston, is cloned cells derived from others into which genes were inserted without using viruses. In the May 8 SCIENCE, the scientists report that the method, which they call "transkaryotic implantation,' circumvents some drawbacks with more established techniques, but they add that transplant usefulness is affected by the implant's location, size and compatibility with the recipient.
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Title Annotation:transkaryotic implantation
Publication:Science News
Date:May 16, 1987
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