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Regulation of inflammatory cytokine-promoted tumorigenesis and metastasis.

The American Cancer Society estimates 1.7 million new cancer diagnoses in 2014 in the United States alone. The World Health Organization has calculated an estimated an increase in cancer related deaths to 13.5 million worldwide by the year 2030. Breast cancer remains one of the most prevalent malignancies facing women today. It is estimated that there will be over 230,000 new incidents of invasive breast cancer in the United States in 2014 (with more than 1,000 cases occurring among Idaho women), as well as greater than 40,000 breast cancer related deaths (nearly 200 of which will transpire in the state of Idaho). Most cancer deaths are attributable to lack of effective treatment in the prevention of metastasis. While researchers have made great strides in the treatment of cancer, targeted research in the effective prevention of metastasis must continue.

Numerous studies have implicated inflammatory cytokines (proteins that normally help promote inflammation) in the promotion of cancer tumorigenesis and metastasis, though the mechanism of action is not well understood. We will present in vitro data on the regulation of pro-inflammatory cytokines by enzyme-linked immunosorbent assay (ELISA) in breast cancer cell lines (MCF-7, MCF10A, MDA-MD-231, and T47D), prostate cancer cell lines (DU 145 and PC3), as well as a cervical cancer cell line (HeLa). Illumination of molecular mechanisms promoting tumorigenesis could lead to the development of novel target therapies effective in the treatment and prevention of breast cancer metastasis.

Jennifer R. Leggett-Lidgard, Danielle S. Hedeen, and Cheryl L. Jorcyk, Boise State University

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Author:Leggett-Lidgard, Jennifer R.; Hedeen, Danielle S.; Jorcyk, Cheryl L.
Publication:Journal of the Idaho Academy of Science
Article Type:Brief article
Geographic Code:1USA
Date:Dec 1, 2014
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