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Regular analgesic use may decrease breast and ovarian cancer risk.

Gates M, Tworoger S, Eliassen H, Missmer S, Hankinson S. Analgesic use and sex steroid hormone concentrations in postmenopausal women. Cancer Epidemiology, Biomarkers & Prevention, 2010; 19(4): 1033-41.

Postmenopausal women who are regular users of aspirin and other analgesics may have lower oestrogen levels vs nonusers, which could potentially lower the risk for breast or ovarian cancer, according a study. Prior epidemiologic studies suggest that regular analgesic use may decrease risk of breast and ovarian cancer. This study examined the relationship between use of aspirin, non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs), and paracetamol and sex steroid hormone concentrations among 740 postmenopausal women in the US Nurses' Health Study.Women who used NSAIDs at least 15 days per month had significantly lower levels of oestradiol compared with women with no NSAID use. This may have important public health implications if an inverse association between analgesic use and risk of breast or ovarian cancer is confirmed, as analgesics could be easily implemented as a chemopreventive and may decrease risk of several cancers.
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Publication:Community Practitioner
Article Type:Abstract
Geographic Code:4EUUK
Date:Jun 1, 2010
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