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Red Wine Could Protect You From Depression.

If you think holding a glass of red wine can be relegated to a mark of sophistication, think again, since you might need to change your perception.A Wine is much more than that for itA is filled with medicinal benefits.A Researchers have found that a particular compound in wine produces an antidepressant effect on the brain. So, having a glass of wineA on a tiring day could help relieve some of your stress from work.A

Resveratrol is a non-flavonoid polyphenol compound, naturally present on the skin and inside the seeds of grapes as well as berries, offering various health benefits.A TheA ( recent study titled, "The antidepressant- and anxiolytic-like effects of resveratrol: Involvement of phosphodiesterase-4D inhibition," was published in Neuropharmacology on July 15 and shed some light on the relationship between wine and stress hormone corticosterone's enzyme called phosphodiesterase 4 (PDE4).A

When corticosterone accumulates in the brain, it can result in depression and other mental health issues.A Previous research had already highlighted that resveratrol holdsA antidepressant properties, but its impact on PDE4 was not studied before.

In a ( press release A issued by the University of Buffalo, Ying Xu, MD, PhD,A co-lead author, and associate research professor at the School of Pharmacy and Pharmaceutical Sciences, said due to complex physiological relationships between chemicals in the brain, only a third of people on antidepressants benefited from serotonin based antidepressants since there is dearth of knowledge.A

Xiaoxing Yin, PhD, professor at Xuzhou Medical University in China was the other co-lead on the paper. What did the researchers find together? From studying the brains of mice, researchers found that the PDE4 enzyme was indeed released by corticosterone, and they confirmed that it leads to depression and anxious behavior.A

"The enzyme lowers cyclic adenosine monophosphate - a messenger molecule that signals physiological changes such as cell division, change, migration and death - in the body, leading to physical alterations in the brain, " explained by the press release.A

Resveratrol limits the multiplication of the PDE4 enzyme and protects the brain against the negative impact of corticosterone, thus reducing depression consequently.A The research will be useful to develop more effective antidepressants in the future. Despite red wine already offering this benefit, excessive alcohol is accompanied by various other health issues. Therefore,A moderation is the key to absorbing this compound, without health risks.A

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Publication:Medical Daily
Date:Jul 30, 2019
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