Printer Friendly

Recurrence of original tumor common in lung transplants for bronchioloalvelor carcinoma.

While lung transplantation for bronchioloalveolar carcinoma is technically feasible and no longer an absolute contraindication to transplant, recurrence of the original tumor within the donor lungs is common, according to a study appearing in the April 8 issue of The New England Journal of Medicine.

Researchers at the University of Alabama at Birmingham reported on 7 patients with bronchioloalveolar carcinoma and no evidence of metastases who received transplants of either 1 or 2 cadaveric lungs following removal of all native lung tissue. Four of the patients had recurrences of their cancer within the donor lungs, with these recurrences appearing from 10 to 48 months after transplantation.

Because all the recurrences appear to have originated from microscopic disease present at the time of transplantation, it is interesting that "suppression of the cell-mediated immunity required for allograft survival did not clearly enhance the spread or growth [of the cancer]," wrote Robert Garver, MD and colleagues.

The authors suggested that further genetic evaluation of these tumors, with particular attention paid to "genes commonly mutated in lung cancers, may help to define differences that are associated with the variable clinical course of these patients after transplantation."
COPYRIGHT 1999 Transplant Communications, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1999 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Comment:Recurrence of original tumor common in lung transplants for bronchioloalvelor carcinoma.
Publication:Transplant News
Geographic Code:1USA
Date:Apr 12, 1999
Previous Article:Shortage of donor organs, chronic rejection remain to be overcome before lung transplantation viable.
Next Article:Mexican health officials fire five physicians for transplanting kidneys from HIV-positive donor.

Related Articles
Adenoid cystic carcinoma of the paranasal sinuses or nasal cavity: A 40-year review of 35 cases. (Original Article).
Insular carcinoma of the thyroid. (Original Article).
Breast and prostate cancer patients may be candidates for organ transplantation.
Acinic cell carcinoma of the parotid gland: a 15-year review limited to a single surgeon at a single institution.

Terms of use | Copyright © 2018 Farlex, Inc. | Feedback | For webmasters