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Recent Health Concerns about U.S. Cattle Spotlight Continued Need for Early Profiling of Cattle to Monitor Safety of Food Source.

Business Editors/Health/Medical Writers

BIOWIRE2K

PORTLAND, Ore.--(BUSINESS WIRE)--Dec. 29, 2003

OXIS International, Inc. (OTCBB:OXIS) (Nouveau Marche:OXIS):

-- Oxidative Stress Blood Test Used to Profile Cattle for Bovine

Respiratory Disease

-- Cattle Health Profiling Experts Available for Comment

OXIS International, Inc. (OTCBB:OXIS) (Nouveau Marche:OXIS) has profiled the health status of more than 4,000 head of cattle with leading feedlots in the U.S. over the last 18 months, providing the cattle industry with valuable data regarding high and low risk animals for disease susceptibility. Currently the Company's screening tests measure oxidative stress in cattle blood, helping cattlemen identify the early stages of the industry's most prolific cattle-health concern -- Bovine Respiratory Disease or BRD. The use of such animal health profiling programs is likely to increase, according to Company officials, fueled by health concerns of our food sources as well as substantial economic benefits for cattle management.

"Our focus has been on screening cattle for the number-one disease affecting the U.S. cattle industry -- BRD," stated Dr. Bruce Hoffman, veterinarian and director of OXIS' Animal Health Profiling Programs. "While more research is required to determine any link between oxidative stress biomarkers and Bovine Spongiform Encephalopathy (BSE), the Animal Health Profiling Program assists our clients to better recognize disease in general, which keeps our food supply safer."

It is estimated that nearly 25% of the 38 million calves born in the U.S. are pulled as a result of being disease affected, costing cattle producers $1 billion annually. Early identification of susceptible cattle is essential to decrease these losses. OXIS believes that it is the only company to offer a profile that provides a valuable analytical tool for managing the health of cattle.

OXIS is working closely with the feedlot industry, which provided an estimated 28.8 million animals less than 2 years of age to be processed for beef in 2003. Most cases of BSE in Great Britain occurred in dairy cows 3-6 years of age that were fed feeds containing meat and bone material. U.S. beef cows are not fed such material, eliminating the practice that may have caused the increased incidence in Great Britain that peaked in 1993.

"OXIS is committed to animal health and consumer safety," stated Ray R. Rogers, president and CEO of OXIS. "By profiling young animals and identifying high risk animals before slaughter, we believe we offer a valuable tool that enhances the safety of our food supply. Using this profiling approach, cattle can be evaluated ranging from high risk to low risk for likelihood of disease. The feedlot can then manage high-risk cattle to assure early treatment is provided, and likely reduce labor and treatment for lower risk groups in the herd."

For additional information regarding the OXIS Animal Health Profiling Program involving the cattle industry, you may request a white paper entitled "Analytical Method to Manage Bovine Respiratory Disease" by calling 503-247-2378. For an interview with OXIS International management or for additional information on Animal Health Profiling, call 503-452-7621.

OXIS International, headquartered in Portland, Oregon, focuses on developing technologies and products to research, diagnose, treat and prevent diseases associated with damage from free radical and reactive oxygen species -- diseases of oxidative stress. The company holds the rights to three therapeutic classes of compounds in the area of oxidative stress and, through its Health Products division, develops, manufactures and markets products and technologies to diagnose and treat diseases caused by oxidative stress.

Statements in this release that are not purely historical are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, including, without limitation, any statements regarding beliefs, plans, estimates, projections, expectations, goals or intentions regarding the future. Forward-looking statements in this release include the following: that the use of animal health profiling programs is likely to increase and provide substantial economic benefits for cattle management; that OXIS' Animal Health Profiling Program will assist OXIS' clients to better recognize disease in general, which keeps the food supply safer; that early identification of susceptible cattle is essential to decrease losses; that OXIS offers a valuable tool that enhances the safety of the food supply and forward looking statements in OXIS' white paper "Analytical Method to Manage Bovine Respiratory Disease." It is important to note that actual outcomes could differ materially from those in such forward-looking statements due to many factors, including, without limitation, whether the cattle industry adopts OXIS' cattle screening tests and, if the industry does so adopt the tests, the pace of such adoption; OXIS' ability to raise additional capital; regulatory concerns; and the activities of OXIS' competitors. Readers should also refer to the documents filed by the company with the Securities and Exchange Commission, specifically the annual report on Form 10-KSB for the year ended December 31, 2002, filed with the Securities and Exchange Commission on March 31, 2003.
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Date:Dec 29, 2003
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