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Rare Case of Bone Cancer Identified via Brachyury Immunostain, According to Study Published by PiscoMed's Journal AMOR.

Singapore, Singapore, June 03, 2016 --( An exceptionally rare and aggressive malignant bone tumor was positively confirmed via the expressions of a DNA protein transcription factor, according to a recent study by American researchers.

"We herein report an exceptional case of extra-axial dedifferentiated chordoma confirmed by the expression of brachyury, the first case report of this kind," reported surgical pathologist Dr. Evita Bonita Henderson-Jackson and her research colleagues from Moffitt Cancer Center in Tampa, Florida, United States, in a case report offering literature review and pathologists' perspective, published by the open-access peer-reviewed journal Advances in Modern Oncology Research (AMOR).

Chordoma, or bone tumor of the skull and spine, is a very uncommon type of cancer with low prognosis (55% for a five-year survival), and accounts for about 3% of all bone tumors. Dedifferentiated chordoma, meanwhile, is a fatal variant of conventional chordoma that is even rarer, occurring in only 2%-8% of all chordomas. It is typically identified following radiation therapy of primary tumors or as recurrences, and with its additional high-grade sarcomatous elements, i.e. malignancies affecting connective tissues, dedifferentiated chordoma is known to be very aggressive and likely to culminate in distant metastases, thus accelerating the patient's demise to within one year of diagnosis.

It is difficult to identify chordoma - let alone dedifferentiated chordoma - at extra-axial sites, according to the researchers. "There have been only a few reports of primary dedifferentiated chordoma," they noted. "Owing to its rarity, especially when it is in an unusual extra-axial location, primary dedifferentiated chordoma presents a diagnostic challenge."

Clinicians examining a neoplasm would still need to review clinical and radiological findings to determine elements of a metastatic carcinoma, according to the study; however, "[i]f history does not indicate metastasis and tumor of unknown origin is raised, a panel of immunostains including brachyury would be of value," it proposed.

Brachyury, a member of the T-box protein family bounded to specific DNA sequences, is a transcription factor which initiates and regulates the rate of transcription of genetic information, and it is highly expressed in nearly every chordoma tumor.

"[B]rachyury was identified as a sensitive and specific marker for chordoma with the ability to discern between extra-axial chordoma and other chordoma-like lesions such as parachordoma/myoepithelioma," explained Dr. Henderson-Jackson and her research colleagues.

"Given that extra-axial chordomas are rare and our case of extra-axial dedifferentiated chordoma is even rarer, brachyury is extremely useful in confirming the diagnosis," they said, adding that brachyury nuclear expression has been observed in most axial and skull-based chordomas, ranging between 89.7% and 100%, including dedifferentiated and metastatic ones.

For their study, the researchers examined the case of a 68-year-old female suffering from pain and swelling with purple discoloration on her right foot, who was originally diagnosed with plantar fasciitis at a different facility but a post-surgery MRI later reported the presence of a multilobulated and erosive mass.

Noted the study, "A core needle biopsy of the right plantar foot mass was performed at an external hospital and the pathology results showed the possibility of dedifferentiated chondrosarcoma." However, the case referred for consultation at yet another facility, which instead diagnosed the lesion as an epithelioid malignant neoplasm, favoring carcinoma over epithelioid sarcoma, according to the study.

When the patient sought a secondary suggestion from Moffitt Cancer Center, her core biopsy was reviewed, and "the histological sections revealed poorly differentiated malignant neoplasm," reported the authors, while noting that carcinoma, melanoma, and sarcoma were all fair diagnoses at that point.

Upon immunohistochemical staining, however, the "immunostain panel does not support epithelioid sarcoma, melanoma, angiosarcoma, malignant peripheral nerve sheath tumor, renal cell carcinoma, or leiomyosarcoma," said the researchers.

Additionally, closer examination of the core biopsy revealed "small groups of cells that had clear and vacuolated cytoplasm with myxoid matrix" suggestive of a chordoma, according to the study. A brachyury immunostain was performed for confirmation, and it showed uniform and diffuse nuclear positivity.

"Specifically, the recognizable chordoma-like areas were brachyury-positive while the dedifferentiated areas were negative," the authors reported. Given the morphology and immunophenotype, a diagnosis of dedifferentiated chordoma with extra-axial type was rendered.

Additional immunohistochemical stains were performed in order to compare the pattern of staining in the resection to the prior biopsy: "The histomorphology and immunohistochemical staining pattern, including the positive brachyury nuclear expression, were identical to the findings in the core biopsy supporting the diagnosis of dedifferentiated chordoma, extra-axial type," the study concluded.

There are only 10 reported cases of brachyury-positive skeletal extra-axial chordoma in entire English-language scientific literature, according to the researchers. "Based on our knowledge and findings, this report is the first to report an extra-axial dedifferentiated brachyury-positive chordoma," they said.

The case report is available AMOR website at

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PiscoMed Publishing Pte Ltd

Jong Thing Soon


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Date:Jun 3, 2016
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