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REMAINING UTERINE MESONEPHRIC DUCT CYST IN FEMALE DOG (CANIS FAMILIARIS)--FIRST CASE REPORT IN BRAZIL/CISTO DE DUCTO MESONEFRICO UTERINO REMANESCENTE EM CADELA (CANIS FAMILIARIS)--PRIMEIRO RELATO DE CASO NO BRASIL/QUISTE REMANECIENTE DEL DUCTO MESONEFRICO UTERINO EN PERRA (CANIS FAMILIARIS)--PRIMERO RELATO DEL CASO EN BRASIL.

Urinary and genital systems derived from the mesoderm in early of fetal stage in birds and mammals (1). The embryological similarities between the both systems include: pronefric duct appears and disappears at late stages of fetal life, and do not functional in most species; mesonephric duct is functional for short time in the early stages of fetal life, and can develop into permanent organs after fetal life; paramesonephric duct in males--Mullerian duct, and mesonephric duct in females--Wolffian duct, regress and only some portions of them can be seen in organs (2).

During conversion process of urogenital system in primary postnatal functional system, some organs and/or ducts are degenerate and consequently reabsorbed (2). However, they can be completely reabsorbed before or immediately after birth or may remain as vestigial form (2,3). This forms can be replaced by a cystic structure along the urogenital system or retroperitoneal region and/or pelvic cavity (1,3,4).

Remaining uterine mesonephric duct cyst (RUMDC) and secondary manifestations in dogs are lack in literature. Default documented reports over RUMDC in dogs can lead to incorrect diagnosis due to its histopathologycal similarity to other conditions, as neoplasia. The present work aims to describe the first documented case report about remaining uterine mesonephric duct cyst and secondary manifestations in female Pinscher dog, with 8 years old.

A female Pinscher dog, with 8-year-old, 3 kg, non spayed, was presented to the private practice, Sao Paulo, Brazil for a check-up. The dog never had puppies and owner reported no heat at last 18 months. No other physiological alterations were reported. Vaccination and deworming were updated. During clinical examination, cysts were observed in teats of both mammary chain (Figure 1) and without vaginal discharge.

The haemogram, serum biochemistry and urinalysis were normal. The abdominal ultrasound and thorax X ray did not showed any alteration. Thus, the teats were submitted to fine needle aspiration cytology. Cytopathologic examination revealed active macrophages, rare neutrophilus and mesenchymal cells, and homogeneous blue material. Cytological evidence of malignancy was not observed. The cytological findings were consistent with cystic lesion without evidence of malignancy.

Therefore, was performed an ovaryhysterectomy and identified endometrial hyperplasia and slight presence of purulent material on the right uterine horn. Ovaries and uterus were submitted to histopathologycal examination with hematoxiline-eosine (HE). Uterus histopathologycal examination showed endometrial with prismatic and cuboid cells, with acidophilic and eventually vacuolated cytoplasm. Endometrial glands identified tubules with acidophilic material and sometimes dilated and formed small cysts. Cysts were observed in the uterus, delineated by layers of smooth muscle and cuboid cells (Figure 2). There were no alterations regarding the ovaries.

The histopathologycal findings were consistent with remaining uterine mesonephric duct cyst associated with slight endometrial hyperplasia. Was prescribed enrofloxacin (1 mg/kg PO, SID, 10 days) and carprofen (2.2 mg/kg PO, BID, 5 days). Twenty-four hours after surgery, cystic of teats disappeared and skin sutures were removed 7 days after. Clinical examination, haemogram, serum biochemistry, urinalysis, abdominal ultrasound and thorax X-ray were performed at two different moments after surgery, 10 days and 6 months, respectively, and no changes were observed in any of moments.

The present case reported the remaining uterine mesonephric duct cyst in female dog. Apparently, there are no data in the literature about the RUMDC in dogs and can be the first case documented in Brazil. Several urogenital disorders associated with paramesonephric and mesonephric ducts have been described in humans and other mammals by several authors (13,5), but none in dog uterus. Disorders associated with mesonephric duct are commonly diagnosed as neoplasia and may thus had contributed to poor documentation regarding this condition in dogs (4,6-9). On the other hand, the RUMDC is diagnosed accidentally during histopathologycal examination (6), and may also contribute to lack reports.

In the canine female is common to diagnostic the Gartner ducts or cysts that is originating from mesonephric duct remnants which can affect in fertility and health (10). Are more frequently referred to in bitches and can be persist close to the myometrium and the uterine horns (11,12).

The diagnostic of RUMDC was by histopathologycal examination, similar with literature (4,6,7). Ovarian cysts in cattle, pigs and rodents, often secrete high quantity of estrogens, which can cause irregular estrous cycles, persistent estrus and infertility (8,9,13).

According to Bartel et al. (10), cases of Gartner cysts originating from mesonephric duct remnant the ectopic endometrium was characterized by immunohistochemistry (oestrogen and progesterone receptors, proliferation activity, cytokeratin, alpha smooth muscle actin, and vimentin) and lectin histochemistry. In this cases, can be observed hypertrophic cells at the serosal (positive reactions to anti-oestrogen receptor and anti-cytokeratin immunohistochemistry) site of the uteri and in all mesonephric remnants, surface and glandular epithelial cells of the ectopic endometrium gave positive immunoreactions for cytokeratin, oestrogen and progesterone receptors (10). On the other hand, muscle actin and vimentin positive can be identified on the stromal cells of the ectopic endometrial (10).

The immunohistochemical characterization of canine mesonephric remnants is slight accessible in Veterinary Medicine, especially in private laboratories, for different reasons, including absence of reagents and pricey. Since histopathologycal changes were observed in both ovaries, it was supposed that cystic structures located in teats and irregular estrus were secondary manifestations to RUMDC, because the cystic lesions disappeared after ovaryhysterectomy. The mesonephric remnants of the mesosalpinx is characterized as a simple tubular structures lined by low columnar to cuboidal cells sometimes featuring cilia with proteinaceous fluid lumina (13).

The correct diagnosis of RUMDC is crucial because can be confused with neoplasia or another similar condition. Cysts on teats and irregular estrus were associated with RUMDC, and ovaryhysterectomy is an option to treat this condition in dogs.

Recebido em: 02/02/2015

Aceito em: 30/03/2017

REFERENCES

(1.) Inomata T, Inoue S, Sugawara H, Kajihara H, Shinomiya T, Wagai I, et al. Developmental changes in paramesonephric and mesonephric ducts and the external genitalia in swine fetuses during sexual differentiation. J Vet Med Sci. 1993;55:371-8.

(2.) Weiss JP. Embryogenesis of ureteral anomalies: a unifying theory. Aust N Z J Surg. 1988;58:631-8.

(3.) Lawrence WD, Whitaker D, Sugimura H, Cunha GR, Dickersin GR, Robboy SJ. An ultrastructural study of the developing urogenital tract in early human fetuses. Am J Obstet Gynecol. 1992;167:185-93.

(4.) Ravo B, Metwally N, Pai PB, Ger R. Developmental retroperitoneal cysts of the pelvis, a review. Dis Colon Rectum. 1987;30:559-64.

(5.) Hadlow WJ, Race RE. Common occurrence of urethral cysts in older female ranch mink. Vet Pathol. 1981;18:599-607.

(6.) Ferry JA, Scully RE. Mesonephric remnants, hyperplasia, and neoplasia in the uterine cervix. A study of 49 cases. Am J Surg Pathol. 1990;14:1100-11.

(7.) Gikas PW, Del Buono EA, Epstein JI. Florid hyperplasia of mesonephric remnants involving prostate and periprostatic tissue, possible confusion with adenocarcinoma. Am J Surg Pathol. 1993;17:454-60.

(8.) Peluso JJ, England-Charlesworth C. Formation of ovarian cysts in aged irregularly cycling rats. Biol Reprod. 1981;24:1183-90.

(9.) Gelberg HB, McEntee K, Heath EH. Feline cystic rete ovarii. Vet Pathol. 1984;21:304-7.

(10.) Bartel C, Berghold P, Walter I. Ectopic endometrial tissue in mesonephric duct remnants in bitches. Reprod Domest Anim. 2011;46:950-6.

(11.) Moifo B, Garel C, Weisgerber G, El Ghoneimi A, Sebag G. Gartner's cyst communicating with the bladder and vagina with associated complete vaginal diaphragm. J Radiol. 2005;86:170-2.

(12.) Schlafer DH, Gifford AT. Cystic endometrial hyperplasia, pseudo-placentational endometrial hyperplasia, and other cystic conditions of the canine and feline uterus Theriogenology. 2008;70:349-58.

(13.) Gelberg HB, McEntee K. Pathology of the canine and feline uterine tube. Vet Pathol. 1986;23:770-5.

Ivan F. Charas Santos [1]

Maira Duarte Del Poente [2]

Bruna Brancalion [3]

Bruna Martins Silva [3]

Mayara Viana Freire Gomes [3]

Frederico Matheus Ducatti Gois [3]

Diana Milanez Avila Dias Maciel [3]

[1] Universidade Estadual Paulista-Faculdade de Medicina Veterinaria e Zootecnia. Botucatu, SP. Brasil. Universidade Eduardo Mondlane. Faculdade de Veterinaria. Maouto, Mocambique. Contato principal para correspondencia.

[2] Medica Veterinaria Autonoma. Sao Paulo

[3] Graduanda em Medicina Veterinaria. Faculdade de Medicina Veterinaria e Zootecnia. UNESP. Botucatu

Caption: Figure 1. Female Pinscher dog, 8-year-old, showing cysts in teats of both mammary chain (white arrows) (Ivan Santos).

Caption: Figure 2. Photomicrography of female Pinscher dog, 8-year-old, diagnosed with remaining uterine mesonephric duct cyst. END--Endometrium with prismatic and cuboid cells, with acidophilic and eventually vacuolated cytoplasm. GE--Endometrial glands. CIS--Cyst with acidophilic material delineated by layers of smooth muscle and cuboid cells. HEM--Hemorrhage. (HE. 40x) [Bar:100 [micro]m] (Ivan Santos).
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Author:Santos, Ivan F. Charas; Del Poente, Maira Duarte; Brancalion, Bruna; Silva, Bruna Martins; Gomes, Ma
Publication:Veterinaria e Zootecnia
Date:Jun 1, 2017
Words:1420
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