Quetiapine induced myoclonus in young male patient.
DISCUSSION: Two large clinical trials demonstrated quetiapine's efficacy for bipolar depression. At 300 and 600 mg/day doses (Calabrese et al., 2005a; Thase et al., 2006). Quetiapine also has antidepressant efficacy in unipolar major depression trials, suggesting that it could be used as monotherapy for depression. The explanation is likely that its primary metabolite, norquetiapine, is a potent norepinephrine reuptake inhibitor (Jensen et al., 2008) (3). Two similar cases were reported in Indian journal of medical sciences volume 62, no 10, October 2008 by Ashish Aggarwal, R. C. Jiloha, Department of Psychiatry, G.B.Pant Hospital, New Delhi, India. Hence the present case report, as a rare case of quetiapine induced myoclonus as an adverse drug reaction.
CONCLUSION: This case highlight the need for careful monitoring of patients on quetiapine for drug induced myoclonus as these movements are dose related and completely abated on reducing the dose.
(1.) Tripathi K. D. Essentials of medical pharmacology, seventh edition. New Delhi, Jaypee Brothers Medical Publishers 2013; p442.
(2.) Amman B. L, Pogarell O, Mergl R, Juckel G, Grunze H, Mulert C, et al. EEG abnormalities associated with antipsychotics: A comparison of quetiapine, olanzapine, haloperidol and healthy subjects. Hum psychopharmacol 2003; 18: 641-6.
(3.) Chabner B, Knollman B. Goodman and Gilman's the pharmacological basis of therapeutics 12th edition. New York: McGraw-Hill; 2011. p421.
Mohd. Sajid , Ashok Binjawadgi , Patil B. V , S. H. Vardhamane , Basavaraj B 
[1.] Mohd. Sajid
[2.] Ashok Binjawadgi
[3.] Patil B. V.
[4.] S. H. Vardhamane
[5.] Basavaraj B.
PARTICULARS OF CONTRIBUTORS:
[1.] Post Graduate Resident, Department Pharmacology, MRMC, Gulbarga.
[2.] Associate Professor, Department Pharmacology, MRMC, Gulbarga.
[3.] Professor, Department Pharmacology, MRMC, Gulbarga.
[4.] Professor, Department Pharmacology, MRMC, Gulbarga.
[5.] Post Graduate Resident, Department Pharmacology, MRMC, Gulbarga.
NAME ADDRESS EMAIL ID OF THE CORRESPONDING AUTHOR:
Dr. Ashok Binjawadgi, Associate Professor, Department of Pharmacology, MRMC, Gulbarga.
Date of Submission: 31/01/2014.
Date of Peer Review: 01/02/2014.
Date of Acceptance: 08/02/2014.
Date of Publishing: 21/02/2014.
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|Title Annotation:||CASE REPORT|
|Author:||Sajid, Mohd.; Binjawadgi, Ashok; V, Patil B.; Vardhamane, S.H.; Basavaraj, B.|
|Publication:||Journal of Evolution of Medical and Dental Sciences|
|Article Type:||Clinical report|
|Date:||Feb 24, 2014|
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