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Questions about estradiol.

I have two questions for Shannon Wills, Ph.D., whose research was featured in the article, "Study: Vaginal Estrogen Ups Serum Estradiol" (March 2010, p. 4):

* How do pmol/L compare to ng/mL?

* What levels of estradiol do premenopausal women have in pmol/L?

John DeKeyser, M.D.

Anchorage, Alaska

Dr. Wills replies:

After conferring with my colleagues, Elizabeth Folkerd, Ph.D., and Mitch Dowsett, Ph.D., I ascertained that most clinical assays report estradiol in pmol/L or pg/mL. To convert from pg/mL to pmol/L, use the following formula: pg/mL estradiol x 3.67 = pmol/L.

In response to Dr. DeKeyser's second question, generally speaking, circulating estradiol in premenopausal women is greater than 150 pmol/L or greater than 40 pg/mL. However, it is important to note that circulating estradiol is highly variable in premenopausal women, as it is dependent on, among other things, the time in their menstrual cycle.

Estradiol levels in postmenopausal women are commonly in the range of 10-60 pmol/L, although levels can be higher in women with a very high body mass index. For women taking an aro-matase inhibitor, estradiol levels are usually below the detection limit for most methods of quantification. With our sensitive assay, estradiol values are rarely above 5 pmol/L (1.4 pg/mL) for women using an aromatase inhibitor.
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Title Annotation:LETTERS
Author:DeKeyser, John
Publication:OB GYN News
Date:Sep 1, 2010
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